Two structures of cyclophilin 40: Folding and fidelity in the TPR domains

Structure

Volumn 9, Issue 5, 2001, Pages 431-438

  Taylor, Paul ^a   Dornan, Jacqueline ^a   Carrello, Amerigo ^b,c   Minchin, Rodney F ^c   Ratajczak, Thomas ^b,c   Walkinshaw, Malcolm D ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b Charles Gairdner Hospital   (United Kingdom)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Cyclophilin; Hsp90; Immunophilin; Protein recognition; Tetratricopeptide repeat; TPR

Indexed keywords

CALMODULIN BINDING PROTEIN; CYCLOPHILIN; CYCLOPHILIN 40; HEAT SHOCK PROTEIN 90; HELIX LOOP HELIX PROTEIN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CARRIER PROTEINS; CATTLE; CRYSTALLOGRAPHY, X-RAY; CYCLOPHILINS; HSP90 HEAT-SHOCK PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PEPTIDYLPROLYL ISOMERASE; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 0034980394     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(01)00603-7     Document Type: Article

References (30)

1. P59, an hsp 90-binding protein. Cloning and sequencing of its cDNA and preparation of a peptide-directed polyclonal antibody
2. Expression and characterization of human fkbp52, an immunophilin that associates with the 90-kda heat-shock protein and is a component of steroid-receptor complexes
3. Cyclophilin-40, a protein with homology to the p59 component of the steroid-receptor complex. Cloning of the cDNA and further characterization
4. The cyclophilin component of the unactivated estrogen-receptor contains a tetratricopeptide repeat domain and shares identity with p59 (fkbp59)
5. Molecular cloning of human fkbp51 and comparisons of immunophilin interactions with hsp90 and progesterone receptor
6. Identification of 2 cyp-40-like cyclophilins in saccharomyces cerevisiae, one of which is required for normal growth
7. Cns1 encodes an essential p60/sti1 homolog in saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with hsp90
8. A cyclophilin function in hsp90-dependent signal-transduction
9. The cyclosporine a-binding immunophilin CyP-40 and the FK506-binding immunophilin hsp56 bind to a common site on hsp90 and exist in independent cytosolic heterocomplexes with the untransformed glucocorticoid receptor
10. Cyclophilin-40 (cyp-40), mapping of its hsp90 binding domain and evidence that fkbp52 competes with cyp-40 for hsp90 binding
11. Three-dimensional structure and actions of immunosuppressants and their immunophilins
12. X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin a
13. Biochemical and structural characterization of a divergent loop cyclophilin from Caenorhabitis elegans
14. The x-ray structure of a divergent cyclophilin from the nematode parasite brugia malayi
15. Isolation and characterization of a 40-kda cyclophilin-related protein
16. Cloning, expression, and purification of human cyclophilin in escherichia-coli and assessment of the catalytic role of cysteines by site-directed mutagenesis
17. The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs
18. Helix packing angle preferences
19. The structure of the tetratricopeptide repeats of protein phosphatase 5: Implications for tpr-mediated protein-protein interactions
20. Biochemical and calmodulin-binding properties of estrogen-receptor binding cyclophilin expressed in escherichia-coli
21. A maize FK506-sensitive immunophilin, mzFKBP-66, is a peptidylproline cis-trans-isomerase that interacts with calmodulin and a 36-kDa cytoplasmic protein
22. Rabbit fkbp59-heat shock protein-binding immunophillin (hbi) is a calmodulin binding-protein
23. From synthetic coiled coils to functional proteins: Automated design of a receptor for the calmodulin-binding domain of calcineurin
24. Identification of conserved residues required for the binding of a tetratricopeptide repeat domain to heat shock protein 90
25. The common tetratricopeptide repeat acceptor site for steroid receptor-associated immunophilins and Hop is located in the dimerization domain of hsp90
26. Purification characterisation and crystallisation in two ctrystal forms of bovine Cyclophilin 40
27. Structure of TPR domain-peptide complexes: Critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine
28. AMoRe: An automated package for molecular replacement
29. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
30. Molscript: A program to produce both detailed and schematic plots of protein structures