TLR4 elimination prevents synaptic and myelin alterations and long-term cognitive dysfunctions in adolescent mice with intermittent ethanol treatment

Brain, Behavior, and Immunity

Volumn 45, Issue , 2015, Pages 233-244

  Montesinos, Jorge ^a   Pascual, María ^a   Pla, Antoni ^a   Maldonado, Concepción ^b   Rodríguez Arias, Marta ^b   Miñarro, Jose ^b   Guerri, Consuelo ^a  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Adolescence; Binge ethanol treatment; Cognitive behavior; Myelin alterations; Synaptic dysfunction; TLR4

Indexed keywords

2',3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE; ALCOHOL; CYCLOOXYGENASE 2 INHIBITOR; HIGH MOBILITY GROUP B1 PROTEIN; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 17; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 1; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELIN; MYELIN BASIC PROTEIN; MYELIN PROTEIN; NEURON GLIAL ANTIGEN 2; NITRIC OXIDE; PROTEOLIPID PROTEIN; SYNAPSIN II; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNAPTOTAGMIN; SYNTAXIN 4; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CENTRAL DEPRESSANT AGENT; CYCLOOXYGENASE 2; HMGB1 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NOS2 PROTEIN, MOUSE; PTGS2 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE;

ADOLESCENT; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; IMMUNE RESPONSE; INNATE IMMUNITY; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; OXIDATIVE STRESS; PASSIVE AVOIDANCE TEST; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SYNAPTIC INHIBITION; YOUNG ADULT; ALCOHOLISM; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MYELIN SHEATH; SYNAPSE; ULTRASTRUCTURE;

ALCOHOL-RELATED DISORDERS; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; COGNITION; COGNITION DISORDERS; CYCLOOXYGENASE 2; ETHANOL; HMGB1 PROTEIN; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MYELIN PROTEINS; MYELIN SHEATH; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; SIGNAL TRANSDUCTION; SYNAPSES; TOLL-LIKE RECEPTOR 4;

EID: 84924130178     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2014.11.015     Document Type: Article

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