Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis

Nature Neuroscience

Volumn 5, Issue 1, 2002, Pages 19-26

  Washbourne, Philip ^a,c   Thompson, Peter M ^a,d   Carta, Mario ^a   Costa, Edmar T ^a,e   Mathews, James R ^a   Lopez Benditó, Guillermina ^b   Molnár, Zoltán ^b   Becher, Mark W ^a   Valenzuela, C Fernando ^a   Partridge, L Donald ^a   Wilson, Michael C ^a  

^a UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Mays Cancer Center at UT Health San Antonio   (United States)

^e FEDERAL UNIVERSITY OF PARÁ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

SNARE PROTEIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; EXOCYTOSIS; FETUS; GENETIC ANALYSIS; MOUSE; NERVE CELL; NERVE FIBER GROWTH; NERVE GROWTH; NEUROMUSCULAR SYNAPSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SYNAPTIC TRANSMISSION;

ANIMALS; BRAIN; CELLS, CULTURED; DERMIS; DIAPHRAGM; EMBRYO; EMBRYONIC AND FETAL DEVELOPMENT; EXOCYTOSIS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MUSCLE, SKELETAL; NERVE TISSUE PROTEINS; NEUROMUSCULAR JUNCTION; NEURONS; PATCH-CLAMP TECHNIQUES; SNARE PROTEINS; SYNAPTIC TRANSMISSION; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25; VESICULAR TRANSPORT PROTEINS;

EID: 0036138744     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn783     Document Type: Article

References (48)

1. Spontaneous release of transmitter from growth cones of embryonic neurones
2. Neurotransmitter secretion along growing nerve processes: Comparison with synaptic vesicle exocytosis
3. SNAP receptors implicated in vesicle targeting and fusion
4. 2+-dependent exocytosis
5. SNAREpins: Minimal machinery for membrane fusion
6. Neurotoxins affecting neuroexocytosis
7. A conserved domain is present in different families of vesicular fusion proteins: A new superfamily
8. Distinct requirements for evoked and spontaneous release of neurotransmitter are revealed by mutations in the Drosophila gene neuronal-synaptobrevin
9. Syntaxin and synaptobrevin function downstream of vesicle docking in Drosophila
10. Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects
11. Different VAMP/synaptobrevin complexes for spontaneous and evoked transmitter release at the crayfish neuromuscular junction
12. 2+ partially rescues synaptic transmission in hippocampal cultures treated with botulinum toxin A and C, but not tetanus toxin
13. Tetanus toxin blocks the exocytosis of synaptic vesicles clustered at synapses but not of synaptic vesicles in isolated axons
14. Inhibition of axon growth by SNAP-25 antisense oligonucleotides in vitro and in vivo
15. Common and distinct fusion proteins in axonal growth and transmitter release
16. Distribution of synaptosomal-associated protein 25 in nerve growth cones and reduction of neurite outgrowth by botulinum neurotoxin A without altering growth cone morphology in dorsal root ganglion neurons and PC-12 cells
17. Subcellular localization of tetanus neurotoxin-insensitive vesicle-associated membrane protein (VAMP)/VAMP7 in neuronal cells: Evidence for a novel membrane compartment
18. Structure of the chicken gene for SNAP-25 reveals duplicated exons encoding distinct isoforms of the protein
19. SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils
20. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution
21. The 25 kDa synaptosomal-associated protein SNAP-25 is the major methionine-rich polypeptide in rapid axonal transport and a major substrate for palmitoylation in adult CNS
22. Multiple palmitoylation of synaptotagmin and the t-SNARE SNAP-25
23. Characterization of the palmitoylation domain of SNAP-25
24. The cysteines of synaptosome-associated protein of 25 kDa (SNAP-25) are required for SNARE disassembly and exocytosis, not for membrane targeting
25. Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues
26. Organization of the secretory machinery in the rodent brain: Distribution of t-SNAREs SNAP-25 and SNAP-23
27. Synaptic assembly of the brain in the absence of neurotransmitter secretion
28. 2+-dependent recycling of synaptic vesicles at the frog neuromuscular junction
29. Calcium-independent actions of α-latrotoxin on spontaneous and evoked synaptic transmission in the hippocampus
30. Exoendocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neurons
31. Quantal components of the end-plate potential
32. Structural changes after transmitter release at the frog neuromuscular junction
33. +2-dependent triggering of neurotransmitter exocytosis
34. Synaptic vesicle membrane fusion complex: Action of clostriridal neurotoxins on assembly
35. Clostridal neurotoxins compromise the stability of a low energy SNARE complex mediating NSF activation of synaptic vesicle fusion
36. Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation
37. Distinctive roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse
38. 2+ sensor for transmitter release at a central synapse
39. A conformational switch in syntaxin during exocytosis: Role of munc18
40. Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses
41. Miniature synaptic events maintain dendritic spines via AMPA receptor activation
42. SNARE function analyzed in synaptobrevin/VAMP knockout mice
43. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
44. Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
45. Adaptation of quantal content to decreased postsynaptic sensitivity at single endplates in α-bungarotoxin-treated rats
46. Preparative methods for brain slices: A discussion
47. Acute effects of ethanol on kainate receptors in cultured hippocampal neurons