Treatment with the PARP inhibitor, niraparib, sensitizes colorectal cancer cell lines to irinotecan regardless of MSI/MSS status

Cancer Cell International

Volumn 15, Issue 1, 2015, Pages

  Genther Williams, Sybil M ^a   Kuznicki, Apryle M ^a   Andrade, Paula ^a   Dolinski, Brian M ^a   Elbi, Cem ^a,b   O'Hagan, Ronan C ^a   Toniatti, Carlo ^a,c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b BAYER CORPORATION   (United States)

^c Institute for Applied Cancer Science   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIRTECAN; IRINOTECAN; NIRAPARIB;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CLINICAL EVALUATION; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; EC50; HCT116 CELL LINE; HT 29 CELL LINE; IN VITRO STUDY; IN VIVO STUDY; MICROSATELLITE INSTABILITY; MICROSATELLITE STABLE; MOUSE; MULTIPLE CYCLE TREATMENT; NONHUMAN; PHENOTYPE; POPULATION GENETIC PARAMETERS;

EID: 84924038002     PISSN: None     EISSN: 14752867     Source Type: Journal    
DOI: 10.1186/s12935-015-0162-8     Document Type: Article

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