Myocardial gene expression of T-bet, GATA-3, Ror-γ t, FoxP3, and hallmark cytokines in chronic Chagas disease cardiomyopathy: An essentially unopposed T-Type response

Mediators of Inflammation

Volumn 2014, Issue , 2014, Pages

  Nogueira, Luciana Gabriel ^a   Santos, Ronaldo Honorato Barros ^a   Fiorelli, Alfredo Inácio ^a   Mairena, Eliane Conti ^a   Benvenuti, Luiz Alberto ^a   Bocchi, Edimar Alcides ^a   Stolf, Noedir Antonio ^a   Kalil, Jorge ^a   Cunha Neto, Edecio ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12P35; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 23; INTERLEUKIN 27; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; RETINOID RELATED ORPHAN RECEPTOR GAMMA; RETINOID RELATED ORPHAN RECEPTOR GAMMA T; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL POPULATION; CHAGAS DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; MALE; MIDDLE AGED; PATHOGENESIS; PRIORITY JOURNAL; PROGNOSIS; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TH2 CELL; HEART MUSCLE; IMMUNOLOGY; METABOLISM;

ADULT; CHAGAS CARDIOMYOPATHY; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GATA3 TRANSCRIPTION FACTOR; HUMANS; MALE; MYOCARDIUM; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; T-BOX DOMAIN PROTEINS; TH1 CELLS;

EID: 84924037968     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2014/914326     Document Type: Article

References (49)

1. C. J. Schofield, J. Jannin, and R. Salvatella, "The future of Chagas disease control, " Trends in Parasitology, vol. 22, no. 12, pp. 583-588, 2006.
2. L. V. Kirchhoff, L. M. Weiss, M. Wittner, and H. B. Tanowitz, "Parasitic diseases of the heart, " Frontiers in Bioscience, vol. 9, pp. 706-723, 2004.
3. J. R. Coura, "Chagas disease:what is known andwhat isneeded. Abackground article, "Memorias do InstitutoOswaldo Cruz, vol. 102, supplement 1, pp. 113-122, 2007.
4. R. B. Bestetti and G. Muccillo, "Clinical course of chagas heart disease: a comparison with dilated cardiomyopathy, " International Journal of Cardiology, vol. 60, no. 2, pp. 187-193, 1997.
5. E. Cunha-Neto, L. G. Nogueira, P. C. Teixeira et al. , "Immunological and non-immunological effects of cytokines and chemokines in the pathogenesis of chronic Chagas disease cardiomyopathy, "Memorias do Instituto Oswaldo Cruz, vol. 104, supplement 1, pp. 252-258, 2009.
6. S. G. Fonseca, M. M. Reis, V. Coelho et al. , "Locally produced survival cytokines IL-15 and IL-7 may be associated to the predominance of CD8+ T cells at heart lesions of human chronic chagas disease cardiomyopathy, " Scandinavian Journal of Immunology, vol. 66, no. 2-3, pp. 362-371, 2007.
7. M. de Lourdes Higuchi, P. S. Gutierrez, V. D. Aiello et al. , "Immunohistochemical characterization of infiltrating cells in human chronic chagasicmyocarditis: comparison withmyocardial rejection process, " Virchows Archiv A: Pathological Anatomy and Histopathology, vol. 423, no. 3, pp. 157-160, 1993.
8. M. de Lourdes Higuchi, C. F. de Morais, A. C. P. Barreto et al. , "The role of active myocarditis in the development of heart failure in chronic Chagas disease: a study based on endomyocardial biopsies, " Clinical Cardiology, vol. 10, no. 11, pp. 665-670, 1987.
9. A. Bafica, H. C. Santiago, R. Goldszmid, C. Ropert, R. T. Gazzinelli, and A. Sher, "Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection, " Journal of Immunology, vol. 177, no. 6, pp. 3515-3519, 2006.
10. V. Michailowsky, N. M. Silva, C. D. Rocha, L. Q. Vieira, J. Lannes-Vieira, and R. T. Gazzinelli, "Pivotal role of interleukin-12 and interferon-γ axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection, " The American Journal of Pathology, vol. 159, no. 5, pp. 1723-1733, 2001.
11. A. M. B. Bilate and E. Cunha-Neto, "Chagas disease cardiomyopathy: current concepts of an old disease, " Revista do Instituto deMedicina Tropical de Sao Paulo, vol. 50, no. 2, pp. 67-74, 2008.
12. M. M. Teixeira, R. T. Gazzinelli, and J. S. Silva, "Chemokines, inflammation and Trypanosoma cruzi infection, " Trends in Parasitology, vol. 18, no. 6, pp. 262-265, 2002.
13. A. P. M. P. Marino, A. Da Silva, P. dos Santos et al. , "Regulated on activation, normal T cell expressed and secreted (RANTES) antagonist (Met-RANTES) controls the early phase of Trypanosoma cruzi-elicited myocarditis, " Circulation, vol. 110, no. 11, pp. 1443-1449, 2004.
14. L. C. J. Abel, L. V. Rizzo, B. Ianni et al. , "Chronic Chagas disease cardiomyopathy patients display an increased IFN-γ response to Trypanosoma cruzi infection, " Journal of Autoimmunity, vol. 17, no. 1, pp. 99-107, 2001.
15. M. Ribeirao, V. L. Pereira-Chioccola, L. Renia, A. A. F. Filho, S. Schenkman, and M. M. Rodrigues, "Chagasicpatientsdevelop a type 1 immune response to Trypanosoma cruzi trans-sialidase, " Parasite Immunology, vol. 22, no. 1, pp. 49-53, 2000.
16. D. D. Reis, E. M. Jones, S. Tostes et al. , "Expression of major histocompatibility complex antigens and adhesion molecules in hearts of patients with chronic Chagas disease, " The American Journal of Tropical Medicine andHygiene, vol. 49, no. 2, pp. 192-200, 1993.
17. F. F. de Araujo, R. Correa-Oliveira, M. O. C. Rocha et al. , "Foxp3+CD25 highCD4+ regulatory T cells fromindeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity, " Immunobiology, vol. 217, no. 8, pp. 768-777, 2012.
18. E. Cunha-Neto and J. Kalil, "Heart-infiltrating and peripheral T cells in the pathogenesis of human Chagas disease cardiomyopathy, " Autoimmunity, vol. 34, no. 3, pp. 187-192, 2001.
19. A. Talvani, M. O. C. Rocha, A. L. Ribeiro, R. Correa-Oliveira, and M. M. Teixeira, "Chemokine receptor expression on the surface of peripheral blood mononuclear cells in Chagas disease, " The Journal of Infectious Diseases, vol. 189, no. 2, pp. 214-220, 2004.
20. J. A. S. Gomes, L. M. G. Bahia-Oliveira, M. O. C. Rocha, O. A. Martins-Filho, G. Gazzinelli, and R. Correa-Oliveira, "Evidence that development of severe cardiomyopathy in human Chagas disease is due to aTh1-specific immune response, " Infection and Immunity, vol. 71, no. 3, pp. 1185-1193, 2003.
21. F. F. Araujo, J. A. S. Gomes, M. O. C. Rocha et al. , "Potential role of CD4+CD25 regulatory T cells in morbidity in Chagas disease, " Frontiers in Bioscience, vol. 12, no. 8, pp. 2797-2806, 2007.
22. P. M. M. Guedes, F. R. S. Gutierrez, G. K. Silva et al. , "Deficient regulatory T cell activity and low frequency of IL-17-producing T cells correlate with the extent of cardiomyopathy in human Chagas disease, " PLoS Neglected Tropical Diseases, vol. 6, no. 4, Article ID e1630, 2012.
23. L. M. D. Magalhaes, F. N. A. Villani, M. D. C. P. Nunes, K. J. Gollob, M. O. C. Rocha, and W. O. Dutra, "High interleukin 17 expression is correlated with better cardiac function in human chagas disease, "The Journal of Infectious Diseases, vol. 207, no. 4, pp. 661-665, 2013.
24. E. Cunha-Neto, V. J. Dzau, P. D. Allen et al. , "Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas disease cardiomyopathy, " The American Journal of Pathology, vol. 167, no. 2, pp. 305-313, 2005.
25. M. M. Reis, M. D. L. Higuchi, L. A. Benvenuti et al. , "An in situ quantitative immunohistochemical study of cytokines and IL-2R+ in chronic human chagasicmyocarditis: correlation with the presence of myocardial Trypanosoma cruzi antigens, " Clinical Immunology and Immunopathology, vol. 83, no. 2, pp. 165-172, 1997.
26. L. G. Nogueira, R. H. B. Santos, B. M. Ianni et al. , "Myocardial chemokine expression and intensity of myocarditis in chagas cardiomyopathy are controlled by polymorphisms in CXCL9 and CXCL10, " PLoS Neglected Tropical Diseases, vol. 6, no. 10, Article ID e1867, 2012.
27. J. A. S. Gomes, L. M. G. Bahia-Oliveira, M. O. C. Rocha et al. , "Type 1 chemokine receptor expression in Chagas disease correlates with morbidity in cardiac patients, " Infection and Immunity, vol. 73, no. 12, pp. 7960-7966, 2005.
28. T. C. Araujo-Jorge, M. C. Waghabi, A. M. Hasslocher-Moreno et al. , "Implication of transforming growth factor-β1 in Chagas disease myocardiopathy, " The Journal of Infectious Diseases, vol. 186, no. 12, pp. 1823-1828, 2002.
29. F. F. de Araujo, A. B. M. da Silveira, R. Correa-Oliveira et al. , "Characterization of the presence of Foxp3+ T cells from patients with different clinical forms ofChagas disease, " Human Pathology, vol. 42, no. 2, pp. 299-301, 2011.
30. D. B. Rocha Rodrigues, M. A. dos Reis, A. Romano et al. , "In situ expression of regulatory cytokines by heart inflammatory cells in Chagas disease patients with heart failure, " Clinical and Developmental Immunology, vol. 2012, Article ID 361730, 7 pages, 2012.
31. S. A. Miller and A. S. Weinmann, "Common themes emerge in the transcriptional control of T helper and developmental cell fate decisions regulated by the T-box, GATA and ROR families, " Immunology, vol. 126, no. 3, pp. 306-315, 2009.
32. L. Dong, M. Chen, Q. Zhang, L. Li, X. Xu, and W. Xiao, "Tbet/ GATA-3 ratio is a surrogate measure of Th1/Th2 cytokine profiles and may be novel targets for CpG ODN treatment in asthma patients, " Chinese Medical Journal, vol. 119, no. 16, pp. 1396-1399, 2006.
33. M. T. Jorge, T. A. A. Macedo, R. S. Janones, D. P. Carizzi, R. A. G. Heredia, and R. E. S. Acha, "Types of arrhythmia among cases of American trypanosomiasis, compared with those in other cardiology patients, " Annals of Tropical Medicine and Parasitology, vol. 97, no. 2, pp. 139-148, 2003.
34. S. A. Bustin, V. Benes, J. A. Garson et al. , "TheMIQE guidelines: minimum information for publication of quantitative real-time PCRexperiments, " Clinical Chemistry, vol. 55, no. 4, pp. 611-622, 2009.
35. C. A. Hunter and R. Kastelein, "Interleukin-27: balancing protective and pathological immunity, " Immunity, vol. 37, no. 6, pp. 960-969, 2012.
36. D. D. Reis, E. M. Jones, S. Tostes Jr. et al. , "Characterization of inflammatory infiltrates in chronic chagasicmyocardial lesions: presence of tumor necrosis factor-α+ cells and dominance of granzyme A+, CD8+ lymphocytes, " The American Journal of TropicalMedicine and Hygiene, vol. 48, no. 5, pp. 637-644, 1993.
37. M. Torzewski, P. Wenzel, H. Kleinert et al. , "Chronic inflammatory cardiomyopathy of interferon γoverexpressing transgenic mice is mediated by tumor necrosis factor-α, " The American Journal of Pathology, vol. 180, no. 1, pp. 73-81, 2012.
38. L. K. Teixeira, B. P. F. Fonseca, B. A. Barboza, and J. P. B. Viola, "The role of interferon-γ on immune and allergic responses, " Memorias do Instituto Oswaldo Cruz, vol. 100, supplement 1, pp. 137-144, 2005.
39. R. J. Arguello, M. C. Albareda, M. G. Alvarez et al. , "Inhibitory receptors are expressed by Trypanosoma cruzi-specific effector T cells and in hearts of subjects with chronic Chagas disease, " PLoS one, vol. 7, no. 5, p. e35966, 2012.
40. M. Kmieciak, M. Gowda, L. Graham et al. , "Human T cells express CD25 and Foxp3 upon activation and exhibit effector/ memory phenotypes without any regulatory/suppressor function, " Journal of Translational Medicine, vol. 7, article 89, 2009.
41. S. Sakaguchi, K. Wing, Y. Onishi, P. Prieto-Martin, and T. Yamaguchi, "Regulatory T cells: how do they suppress immune responses?" International Immunology, vol. 21, no. 10, pp. 1105-1111, 2009.
42. R. M. Saraiva, M. C. Waghabi, M. F. Vilela et al. , "Predictive value of transforming growth factor-beta1in Chagas disease: towards a biomarker surrogate of clinical outcome, " Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 107, pp. 518-525, 2013.
43. K. Nakanishi, T. Yoshimoto, H. Tsutsui, and H. Okamura, "Interleukin-18 regulates bothTh1 and Th2 responses, " Annual Review of Immunology, vol. 19, pp. 423-474, 2001.
44. M. Tone, S. A. J. Thompson, Y. Tone, P. J. Fairchild, and H. Waldmann, "Regulation of IL-18 (IFN-γ-inducing factor) gene expression, " Journal of Immunology, vol. 159, no. 12, pp. 6156-6163, 1997.
45. C. A. Dinarello and G. Fantuzzi, "Interleukin-18 and host defense against infection, "TheJournal of InfectiousDiseases, vol. 187, supplement 2, pp. S370-S384, 2003.
46. B. Chandrasekar, S. Mummidi, L. Mahimainathan et al. , "Interleukin-18-induced human coronary artery smooth muscle cell migration is dependent on NF-αB-and AP-1-mediated matrix metalloproteinase-9 expression and is inhibited by atorvastatin, "The Journal of Biological Chemistry, vol. 281, no. 22, pp. 15099-15109, 2006.
47. V. S. Reddy, R. E. Harskamp, M. W. van Ginkel et al. , "Interleukin-18 stimulates fibronectin expression in primary human cardiac fibroblasts via PI3K-Akt-dependent NF-αB activation, " Journal of Cellular Physiology, vol. 215, no. 3, pp. 697-707, 2008.
48. H. Jiang, G. Qiu, J. Li-Ling, N. Xin, and K. Sun, "Reduced ACTC1 expression might play a role in the onset of congenital heart disease by inducing cardiomyocyte apoptosis, " Circulation Journal, vol. 74, no. 11, pp. 2410-2418, 2010.
49. A. F. Frade, P. C. Teixeira, B. M. Ianni et al. , "Polymorphism in the alpha cardiac muscle actin 1 gene is associated to susceptibility to chronic inflammatory cardiomyopathy, " PLoS ONE, Article IDe83446, 2013.