Ginsenoside Rg3 improves erectile function in streptozotocin-induced diabetic rats

Journal of Sexual Medicine

Volumn 12, Issue 3, 2015, Pages 611-620

  Liu, Tao ^a   Peng, Yi Feng ^a   Jia, Chao ^a   Yang, Ben Hai ^a   Tao, Xia ^a   Li, Jing ^a   Fang, Xiang ^a  

^a WANNAN MEDICAL COLLEGE   (China)

Author keywords

Apoptosis; Diabetes; Erectile dysfunction; Oxidative stress

Indexed keywords

CARBOXYMETHYLCELLULOSE; CASPASE 3; CD31 ANTIGEN; GINSENOSIDE RG 3; MALONALDEHYDE; PROTEIN BCL 2; PROTEIN BCL XL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; SMOOTH MUSCLE ACTIN; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE; ACTIN; GINSENOSIDE; NITRIC OXIDE SYNTHASE; SMOOTH MUSCLE ACTIN, RAT; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; COLORIMETRY; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG EFFECT; FEEDING; INTRACAVERNOSAL PRESSURE; MALE; MEAN ARTERIAL PRESSURE; NERVE FIBER; NERVE REGENERATION; NERVE STIMULATION; NICK END LABELING; NONHUMAN; PENIS ERECTION; PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SHAM PROCEDURE; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; WESTERN BLOTTING; ANIMAL; COMPLICATION; DOSE RESPONSE; DRUG EFFECTS; ERECTILE DYSFUNCTION; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; PATHOPHYSIOLOGY; PENIS; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ACTINS; ANIMALS; ANTIGENS, CD31; CASPASE 3; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ERECTILE DYSFUNCTION; GINSENOSIDES; MALE; MALONDIALDEHYDE; NITRIC OXIDE SYNTHASE; PENILE ERECTION; PENIS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; STREPTOZOCIN; SUPEROXIDE DISMUTASE;

EID: 84924019615     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/jsm.12779     Document Type: Article

References (30)

1. Shamloul R, Ghanem H. Erectile dysfunction. Lancet 2013;381:153-165.
2. Francis SH, Corbin JD. PDE5 inhibitors: Targeting erectile dysfunction in diabetics. Curr Opin Pharmacol 2011;11:683-688.
3. Cameron NE, Cotter MA. Erectile dysfunction and diabetes mellitus: Mechanistic considerations from studies in experimental models. Curr Diabetes Rev 2007;3:149-158.
4. Choi KT. Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer. Acta Pharmacol Sin 2008;29:1109-1118.
5. Wei X, Su F, Su X, Hu T, Hu S. Stereospecific antioxidant effects of ginsenoside Rg3 on oxidative stress induced by cyclophosphamide in mice. Fitoterapia 2012;83:636-642.
6. Park HM, Kim SJ, Mun AR, Go HK, Kim GB, Kim SZ, Jang SI, Lee SJ, Kim JS, Kang HS. Korean red ginseng and its primary ginsenosides inhibit ethanol-induced oxidative injury by suppression of the MAPK pathway in TIB-73 cells. J Ethnopharmacol 2012;141:1071-1076.
7. Shin YM, Jung HJ, Choi WY, Lim CJ. Antioxidative, anti-inflammatory, and matrix metalloproteinase inhibitory activities of 20(S)-ginsenoside Rg3 in cultured mammalian cell lines. Mol Biol Rep 2013;40:269-279.
8. Tian JW, Fu FH, Geng MY, Jiang YT, Yang JX, Jiang WL, Wang CY, Liu K. Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats. Neurosci Lett 2012;526:106-111.
9. Usta MF, Kendirci M, Gur S, Foxwell NA, Bivalacqua TJ, Cellek S, Hellstrom WJ. The breakdown of preformed advanced glycation end products reverses erectile dysfunction in streptozotocin-induced diabetic rats: Preventive vs. curative treatment. J Sex Med 2006;3:242-250. discussion 250-2.
10. Chen Y, Yang R, Yao L, Sun Z, Wang R, Dai Y. Differential expression of neurotrophins in penises of streptozotocin-induced diabetic rats. J Androl 2007;28:306-312.
11. Chen Y, Li XX, Lin HC, Qiu XF, Gao J, Dai YT, Wang R. The effects of long-term administration of tadalafil on STZ-induced diabetic rats with erectile dysfunction via a local antioxidative mechanism. Asian J Androl 2012;14:616-620.
12. Carson CC, Lue TF. Phosphodiesterase type 5 inhibitors for erectile dysfunction. BJU Int 2005;96:257-280.
13. Musicki B, Liu T, Lagoda GA, Strong TD, Sezen SF, Johnson JM, Burnett AL. Hypercholesterolemia-induced erectile dysfunction: Endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidase. J Sex Med 2010;7:3023-3032.
14. Qiu X, Fandel TM, Lin G, Huang YC, Dai YT, Lue TF, Lin CS. Cavernous smooth muscle hyperplasia in a rat model of hyperlipidaemia-associated erectile dysfunction. BJU Int 2011;108:1866-1872.
15. Ferrini MG, Kovanecz I, Sanchez S, Umeh C, Rajfer J, Gonzalez-Cadavid NF. Fibrosis and loss of smooth muscle in the corpora cavernosa precede corporal veno-occlusive dysfunction (CVOD) induced by experimental cavernosal nerve damage in the rat. J Sex Med 2009;6:415-428.
16. Moore CR, Wang R. Pathophysiology and treatment of diabetic erectile dysfunction. Asian J Androl 2006;8:675-684.
17. Ratnam DV, Ankola DD, Bhardrawj V, Sahana DK, Kumar MN. Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective. J Control Release 2006;113:189-207.
18. Hirata H, Kawamoto K, Kikuno N, Kawakami T, Kawakami K, Saini S, Yamamura S, Dahiya R. Restoring erectile function by antioxidant therapy in diabetic rats. J Urol 2009;182:2518-2525.
19. Angulo J, Peiró C, Cuevas P, Gabancho S, Fernández A, González-Corrochano R, La Fuente JM, Baron AD, Chen KS, de Tejada IS. The novel antioxidant, AC3056 (2, 6-di-t-butyl-4-((dimethyl-4-methoxyphenylsilyl)methyloxy)phenol), reverses erectile dysfunction in diabetic rats and improves NO-mediated responses in penile tissue from diabetic men. J Sex Med 2009;6:373-387.
20. Singh VP, Bali A, Singh N, Jaggi AS. Advanced glycation end products and diabetic complications. Korean J Physiol Pharmacol 2014;18:1-14.
21. Radi R. Peroxynitrite, a stealthy biological oxidant. J Biol Chem 2013;288:26464-26472.
22. Khan MA, Thompson CS, Mumtaz FH, Mikhailidis DP, Morgan RJ, Bruckdorfer RK, Naseem KM. The effect of nitric oxide and peroxynitrite on rabbit cavernosal smooth muscle relaxation. World J Urol 2001;19:220-224.
23. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly. Am J Physiol 1996;271:C1424-1437.
24. Sikka S, Zeng X, Hellstrom WJ. Redox signaling mechanisms and apoptotic response in human cavernosa under oxidative stress. In the 30th Annual Meeting of American Society of Andrology, March 30-April 5, 2005. Seattle, Washington. Abstract 94.
25. Jeremy JY, Angelini GD, Khan M, Mikhailidis DP, Morgan RJ, Thompson CS, Bruckdorfer KR, Naseem KM. Platelets, oxidant stress and erectile dysfunction: An hypothesis. Cardiovasc Res 2000;46:50-54.
26. Bivalacqua TJ, Usta MF, Kendirci M, Pradhan L, Alvarez X, Champion HC, Kadowitz PJ, Hellstrom WJ. Superoxide anion production in the rat penis impairs erectile function in diabetes: Influence of in vivo extracellular superoxide dismutase gene therapy. J Sex Med 2005;2:187-197.
27. Kang KS, Yokozawa T, Yamabe N, Kim HY, Park JH. ESR study on the structure and hydroxyl radical-scavenging activity relationships of ginsenosides isolated from Panax ginseng C A Meyer. Biol Pharm Bull 2007;30:917-921.
28. Min JK, Kim JH, Cho YL, Maeng YS, Lee SJ, Pyun BJ, Kim YM, Park JH, Kwon YG. 20(S)-Ginsenoside Rg3 prevents endothelial cell apoptosis via inhibition of a mitochondrial caspase pathway. Biochem Biophys Res Commun 2006;349:987-994.
29. Vergun O, Sobolevsky AI, Yelshansky MV, Keelan J, Khodorov BI, Duchen MR. Exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurones in culture. J Physiol 2001;531:147-163.
30. Kim JH, Cho SY, Lee JH, Jeong SM, Yoon IS, Lee BH, Lee JH, Pyo MK, Lee SM, Chung JM, Kim S, Rhim H, Oh JW, Nah SY. Neuroprotective effects of ginsenoside Rg3 against homocysteine-induced excitotoxicity in rat hippocampus. Brain Res 2007;1136:190-199.