Restoring Erectile Function by Antioxidant Therapy in Diabetic Rats

Journal of Urology

Volumn 182, Issue 5, 2009, Pages 2518-2525

  Hirata, Hiroshi ^a   Kawamoto, Ken ^a   Kikuno, Nobuyuki ^a   Kawakami, Toshifumi ^a   Kawakami, Kazumori ^a   Saini, Sharanjot ^a   Yamamura, Soichiro ^a   Dahiya, Rajvir ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

diabetes mellitus; gene expression; insulin; penis; tempol

Indexed keywords

CD31 ANTIGEN; COLLAGEN FIBER; COMPLEMENTARY DNA; EOSIN; HEMATOXYLIN; INSULIN; ISOPHANE INSULIN; MESSENGER RNA; NOVLIN; REACTIVE OXYGEN METABOLITE; TEMPOL; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 3; AMINE OXIDE; ANTIOXIDANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROL GROUP; CONTROLLED STUDY; CORPUS CAVERNOSUM; DIABETES MELLITUS; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; MALE; MICROARRAY ANALYSIS; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE; SPRAGUE DAWLEY RAT; STAINING; URINARY TRACT; ANIMAL; CONVALESCENCE; DRUG EFFECT; ERECTILE DYSFUNCTION; EXPERIMENTAL DIABETES MELLITUS; GENETICS; PENIS ERECTION; SPIN LABELING;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CYCLIC N-OXIDES; DIABETES COMPLICATIONS; DIABETES MELLITUS, EXPERIMENTAL; ERECTILE DYSFUNCTION; MALE; MICROARRAY ANALYSIS; PENILE ERECTION; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SPIN LABELS;

EID: 70350435888     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2009.07.009     Document Type: Article

References (21)

1. Bacon C.G., Hu F.B., Giovannucci E., et al. Association of type and duration of diabetes with erectile dysfunction in a large cohort of men. Diabetes Care 25 (2002) 1458
2. Burnett A.L. Erectile dysfunction. J Urol 175 (2006) 25
3. Sasaki K., Yoshimura N., and Chancellor M.B. Implications of diabetes mellitus in urology. Urol Clin North Am 30 (2003) 1
4. Bivalacqua T.J., Liu T., Musicki B., et al. Endothelial nitric oxide synthase keeps erection regulatory function balance in the penis. Eur Urol 51 (2007) 1732
5. Musicki B., and Burnett A.L. eNOS function and dysfunction in the penis. Exp Biol Med (Maywood) 231 (2006) 154
6. De Young L., Yu D., Bateman R.M., et al. Oxidative stress and antioxidant therapy: their impact in diabetes-associated erectile dysfunction. J Androl 25 (2004) 830
7. Göçmen C., Seçilmiş A., Kumcu E.K., et al. Effects of vitamin E and sodium selenate on neurogenic and endothelial relaxation of corpus cavernosum in the diabetic mouse. Eur J Pharmacol 398 (2000) 93
8. Nassar T., Kadery B., Lotan C., et al. Effects of the superoxide dismutase-mimetic compound tempol on endothelial dysfunction in streptozotocin-induced diabetic rats. Eur J Pharmacol 436 (2002) 111
9. Alici B., Gümüstas M.K., Ozkara H., et al. Apoptosis in the erectile tissues of diabetic and healthy rats. BJU Int 85 (2000) 326
10. Nakazawa T., Chiba T., Kaneko E., et al. Insulin signaling in arteries prevents smooth muscle apoptosis. Arterioscler Thromb Vasc Biol 25 (2005) 760
11. Yamanaka M., Shirai M., Shiina H., et al. Diabetes induced erectile dysfunction and apoptosis in penile crura are recovered by insulin treatment in rats. J Urol 170 (2003) 291
12. Shirai M., Yamanaka M., Shiina H., et al. Vascular endothelial growth factor restores erectile function through modulation of the insulin-like growth factor system and sex hormone receptors in diabetic rat. Biochem Biophys Res Commun 341 (2006) 755
13. Sullivan C.J., Teal T.H., Luttrell I.P., et al. Microarray analysis reveals novel gene expression changes associated with erectile dysfunction in diabetic rats. Physiol Genomics 23 (2005) 192
14. De Young L.X., Domes T., Lim K., et al. Endothelial rehabilitation: the impact of chronic PDE5 inhibitors on erectile function and protein alterations in cavernous tissue of diabetic rats. Eur Urol 54 (2008) 213
15. Jia Y.T., Wei W., Ma B., et al. Activation of p38 MAPK by reactive oxygen species is essential in a rat model of stress-induced gastric mucosal injury. J Immunol 179 (2007) 7808
16. Paravicini T.M., and Touyz R.M. Redox signaling in hypertension. Cardiovasc Res 71 (2006) 247
17. Podlasek C.A., Meroz C.L., Tang Y., et al. Regulation of cavernous nerve injury-induced apoptosis by sonic hedgehog. Biol Reprod 76 (2007) 19
18. Simon H.U., Haj-Yehia A., and Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5 (2000) 415
19. Imoto K., Kukidome D., Nishikawa T., et al. Impact of mitochondrial reactive oxygen species and apoptosis signal-regulating kinase 1 on insulin signaling. Diabetes 55 (2006) 1197
20. Bivalacqua T.J., Usta M.F., Kendirci M., et al. Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy. J Sex Med 2 (2005) 187
21. Flandin P., Donati Y., Barazzone-Argiroffo C., et al. Hyperoxia-mediated oxidative stress increases expression of UCP3 mRNA and protein in skeletal muscle. FEBS Lett 579 (2005) 3411