Cavernous smooth muscle hyperplasia in a rat model of hyperlipidaemia- associated erectile dysfunction

BJU International

Volumn 108, Issue 11, 2011, Pages 1866-1872

  Qiu, Xuefeng ^a,b   Fandel, Thomas M ^a   Lin, Guiting ^a   Huang, Yun Ching ^a,c,d   Dai, Yu Tian ^b   Lue, Tom F ^a   Lin, Ching Shwun ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NANJING UNIVERSITY   (China)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

cavernous endothelium; cavernous smooth muscle; collagen type IV; erectile dysfunction; hyperlipidaemia; nNOS positive nerves; phalloidin

Indexed keywords

COLLAGEN TYPE 4; NEURONAL NITRIC OXIDE SYNTHASE; PHALLOIDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; CORPUS CAVERNOSUM; ENDOTHELIUM; ERECTILE DYSFUNCTION; HISTOPATHOLOGY; HYPERLIPIDEMIA; HYPERPLASIA; LIPID DIET; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE HYPERPLASIA;

ANIMALS; COLLAGEN TYPE IV; HYPERLIPIDEMIAS; HYPERPLASIA; IMPOTENCE, VASCULOGENIC; MALE; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE SYNTHASE TYPE I; PENIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 80053894979     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2011.10162.x     Document Type: Article

References (18)

1. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-97
2. Wei M, Macera CA, Davis DR, Hornung CA, Nankin HR, Blair SN,. Total cholesterol and high density lipoprotein cholesterol as important predictors of erectile dysfunction. Am J Epidemiol 1994; 140: 930-7 (Pubitemid 24355556)
3. Roumeguere T, Wespes E, Carpentier Y, Hoffmann P, Schulman CC,. Erectile dysfunction is associated with a high prevalence of hyperlipidemia and coronary heart disease risk. Eur Urol 2003; 44: 355-9 (Pubitemid 37051706)
4. Nikoobakht M, Nasseh H, Pourkasmaee M,. The relationship between lipid profile and erectile dysfunction. Int J Impot Res 2005; 17: 523-6 (Pubitemid 41581705)
5. Miner M, Billups KL,. Erectile dysfunction and dyslipidemia: relevance and role of phosphodiesterase type-5 inhibitors and statins. J Sex Med 2008; 5: 1066-78 (Pubitemid 351618019)
6. Dadkhah F, Safarinejad MR, Asgari MA, Hosseini SY, Lashay A, Amini E,. Atorvastatin improves the response to sildenafil in hypercholesterolemic men with erectile dysfunction not initially responsive to sildenafil. Int J Impot Res 2010; 22: 51-60
7. Gholami SS, Rogers R, Chang J, et al,. The effect of vascular endothelial growth factor and adeno-associated virus mediated brain derived neurotrophic factor on neurogenic and vasculogenic erectile dysfunction induced by hyperlipidemia. J Urol 2003; 169: 1577-81 (Pubitemid 36323848)
8. Huang YC, Ning H, Shindel AW, et al,. The effect of intracavernous injection of adipose tissue-derived stem cells on hyperlipidemia-associated erectile dysfunction in a rat model. J Sex Med 2010; 7: 1391-400
9. Lee MC, El-Sakka AI, Graziottin TM, Ho HC, Lin CS, Lue TF,. The effect of vascular endothelial growth factor on a rat model of traumatic arteriogenic erectile dysfunction. J Urol 2002; 167: 761-7 (Pubitemid 34074581)
10. User HM, Hairston JH, Zelner DJ, McKenna KE, McVary KT,. Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunction. J Urol 2003; 169: 1175-9 (Pubitemid 36188196)
11. Ferrini MG, Kovanecz I, Sanchez S, Umeh C, Rajfer J, Gonzalez-Cadavid NF,. Fibrosis and loss of smooth muscle in the corpora cavernosa precede corporal veno-occlusive dysfunction (CVOD) induced by experimental cavernosal nerve damage in the rat. J Sex Med 2009; 6: 415-28
12. Ryu JK, Shin HY, Song SU, et al,. Downregulation of angiogenic factors and their downstream target molecules affects the deterioration of erectile function in a rat model of hypercholesterolemia. Urology 2006; 67: 1329-34 (Pubitemid 43818077)
13. Ryu JK, Cho CH, Shin HY, et al,. Combined angiopoietin-1 and vascular endothelial growth factor gene transfer restores cavernous angiogenesis and erectile function in a rat model of hypercholesterolemia. Mol Ther 2006; 13: 705-15
14. Ross R, Harker L,. Hyperlipidemia and atherosclerosis. Science 1976; 193: 1094-100
15. Ryu JK, Zhang LW, Jin HR, et al,. Derangements in endothelial cell-to-cell junctions involved in the pathogenesis of hypercholesterolemia- induced erectile dysfunction. J Sex Med 2009; 6: 1893-907
16. Luangkhot R, Rutchik S, Agarwal V, Puglia K, Bhargava G, Melman A,. Collagen alterations in the corpus cavernosum of men with sexual dysfunction. J Urol 1992; 148: 467-71
17. Barnes MJ, Farndale RW,. Collagens and atherosclerosis. Exp Gerontol 1999; 34: 513-25 (Pubitemid 29383870)
18. Raviv G, Wespes E, Vanegas JP, et al,. Difference in glycohistochemical lectin staining of collagen fibers in the corpora cavernosa of normal and impotent men. J Androl 1996; 17: 187-93 (Pubitemid 26181344)