The novel antioxidant, AC3056 (2,6-di-t-butyl-4-((Dimethyl-4-Methoxyphenylsilyl)Methyloxy)Phenol), reverses erectile dysfunction in diabetic rats and improves NO-mediated responses in penile tissue from diabetic men

Journal of Sexual Medicine

Volumn 6, Issue 2, 2009, Pages 373-387

  Angulo, Javier ^a   Peiró, Concepción ^b   Cuevas, Pedro ^a   Gabancho, Sonia ^a   Fernández, Argentina ^a   González Corrochano, Rocío ^a   La Fuente, José M ^c   Baron, Alain D ^d   Chen, Kim S ^d   de Tejada, Iñigo Sáenz ^a  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c HOSPITAL DE SANTO ANTÓNIO   (Portugal)

^d AMYLIN PHARMACEUTICALS INC   (United States)

Author keywords

Antioxidant therapy; Diabetes; Erectile dysfunction; Nitric oxide; Oxidative stress

Indexed keywords

2,6 DI TERT BUTYL 4 [(DIMETHYL 4 METHOXYPHENYLSILYL)METHYLOXY]PHENOL; AC 3056; ACETYLCHOLINE; ANTIOXIDANT; CYCLIC GMP; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALONALDEHYDE; NITRIC OXIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRADYCARDIA; CONTROLLED STUDY; CORPUS CAVERNOSUM; DIABETES MELLITUS; DRUG INHIBITION; DRUG RESPONSE; ELECTROMYOGRAPHY; ERECTILE DYSFUNCTION; GLUCOSE BLOOD LEVEL; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PENILE BLOOD FLOW; PENIS ARTERY; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE RELAXATION; SPRAGUE DAWLEY RAT; STREPTOZOCIN DIABETES;

EID: 59449088209     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2008.01088.x     Document Type: Article

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