Mathematical modeling improves EC50 estimations from classical dose-response curves

FEBS Journal

Volumn 282, Issue 5, 2015, Pages 951-962

  Nyman, Elin ^a,b   Lindgren, Isa ^a   Lövfors, William ^a   Cervin, Ida ^a   Lundengård, Karin ^a   Sjöström, Theresia Arbring ^a   Altimiras, Jordi ^a   Cedersund, Gunnar ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

adrenaline; cardiac adrenergic signaling; dynamic mathematical modeling; EC 50; ordinary differential equations

Indexed keywords

ADRENALIN; BETA ADRENERGIC RECEPTOR STIMULATING AGENT;

ADRENERGIC SYSTEM; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; EC50; HEART MUSCLE CONTRACTILE FORCE; IN VITRO STUDY; MATHEMATICAL MODEL; MEASUREMENT ACCURACY; NONHUMAN; PREDICTION; PRIORITY JOURNAL; SIMULATION; STEADY STATE; UNCERTAINTY; ANIMAL; CHICKEN; DRUG EFFECTS; MUSCLE CONTRACTION; THEORETICAL MODEL;

ADRENERGIC BETA-AGONISTS; ANIMALS; CHICKENS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPINEPHRINE; MODELS, THEORETICAL; MUSCLE CONTRACTION;

EID: 84923929125     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.13194     Document Type: Article

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