Bile acids regulate nuclear receptor (Nur77) expression and intracellular location to control proliferation and apoptosis

Molecular Cancer Research

Volumn 13, Issue 2, 2015, Pages 281-292

  Hu, Ying ^a   Chau, Thinh ^a   Liu, Hui Xin ^a   Liao, Degui ^b   Keane, Ryan ^a   Nie, Yuqiang ^b   Yang, Hui ^b   Wan, Yu Jui Yvonne ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CCN PROTEIN; CYCLIN DEPENDENT KINASE 4; LEPTOMYCIN B; LITHOCHOLIC ACID; NUCLEAR RECEPTOR NUR77; PROTEIN DERIVATIVE; REACTIVE OXYGEN METABOLITE; STAT5A PROTEIN; NR4A1 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARCINOGENICITY; CELL PROLIFERATION; CELL STRESS; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA BINDING; GENE EXPRESSION; GENOTOXICITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; UPREGULATION; ANIMAL; BLOOD; CANCER TRANSPLANTATION; COLORECTAL TUMOR; CYTOLOGY; DRUG EFFECTS; GENETICS; HCT 116 CELL LINE; HT-29 CELL LINE; LIVER CELL; LIVER TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; BILE ACIDS AND SALTS; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; HCT116 CELLS; HEPATOCYTES; HT29 CELLS; HUMANS; LIVER NEOPLASMS; MICE; NEOPLASM TRANSPLANTATION; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1;

EID: 84923917467     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-14-0230     Document Type: Article

References (34)

1. Gadaleta RM, van Mil SWC, Oldenburg B, Siersema PD, Klomp LWJ, van Erpecum KJ. Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease. BBA-Mol Cell Bio L 2010;1801:683-92.
2. Bernstein H, Bernstein C, Payne CM, Dvorak K. Bile acids as endogenous etiologic agents in gastrointestinal cancer. World J Gastroentero 2009;15:3329-40.
3. Graessler J, Qin Y, Zhong H, Zhang J, Licinio J, Wong ML, et al. Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters. Pharmacogenomics J 2013;13:514-22.
4. Bar-Yishay I, Shaul Y, Shlomai A. Hepatocyte metabolic signalling pathways and regulation of hepatitis B virus expression. Liver Int 2011;31:282-90.
5. Chhatwal P, Bankwitz D, Gentzsch J, Frentzen A, Schult P,Lohmann V, et al. Bile acids specifically increase hepatitis C virus RNA-replication. PLoS One 2012;7.
6. Reese VC, Oropeza CE, McLachlan A. Independent activation of hepatitis B virus biosynthesis by retinoids, peroxisome proliferators, and bile acids. J Virol 2013;87:991-7.
7. Muller N, Petzinger E. Hepatocellular uptake of aflatoxin B1 by non-ionic diffusion. Inhibition of bile acid transport by interference with membrane lipids. Biochim Biophys Acta 1988;938:334-44.
8. Beyoglu D, Idle JR. The metabolomic window into hepatobiliary disease. J Hepatol 2013;59:842-58.
9. Poupon R. Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: an overview of their mechanisms of action. Clin Res Hepatol Gas 2012;36:S3-S12.
10. Allen K, Jaeschke H, Copple BL. Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis. Am J Pathol 2011;178:175-86.
11. Moll UM, Marchenko N, Zhang XK. p53 and Nur77/TR3 - transcription factors that directly target mitochondria for cell death induction. Oncogene 2006;25:4725-43.
12. Lin B, Kolluri SK, Lin F, Liu W, Han YH, Cao X, et al. Conversion of Bcl-2 from protector to killer by interactionwith nuclear orphan receptor Nur77/TR3. Cell 2004;116:527-40.
13. To SK, Zeng WJ, Zeng JZ, Wong AS. Hypoxia triggers a Nur77-β-catenin feed-forward loop to promote the invasive growth of colon cancer cells. Br J Cancer 2014;110:935-45.
14. Kolluri SK, Bruey-Sedano N, Cao X, Lin B, Lin F, Han YH, et al. Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cells. Mol Cell Biol 2003;23:8651-67.
15. Yang H, Zhan Q, Wan YJ. Enrichment of Nur77 mediated by retinoic acid receptor beta leads to apoptosis of human hepatocellular carcinoma cells induced by fenretinide and histone deacetylase inhibitors. Hepatology 2011;53:865-74.
16. Yang H, Nie Y, Li Y, Wan YJ. ERK1/2 deactivation enhances cytoplasmic Nur77 expression level and improves the apoptotic effect of fenretinide in human liver cancer cells. Biochem Pharmacol 2011;81:910-6.
17. Hsu HC, Zhou T, Mountz JD. Nur77 family of nuclear hormone receptors. Curr Drug Targets Inflamm Allergy 2004;3:413-23.
18. Hu Y, Liu HX, He Y, Fang Y, Fang J, Wan YJ. Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells. Biochem Pharmacol 2013;85:1007-17.
19. Song PZ, Zhang YC, Klaassen CD. Dose-response of five bile acids on serum and liver bile acid concentrations and hepatotoxicty in mice. Toxicol Sci 2011;123:359-67.
20. Bernstein H, Bernstein C, Payne CM, Dvorakova K,Garewal H. Bile acids as carcinogens in human gastrointestinal cancers.Mutat Res-Rev Mutat 2005;589:47-65.
21. Kudo N, Matsumori N, Taoka H, Fujiwara D, Schreiner EP, Wolff B, et al. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci U S A 1999;96:9112-7.
22. Zhao YG, Liu YX, Zheng DX. Alpha 1-antichymotrypsin/SerpinA3 is a novel target of orphan nuclear receptor Nur77. FEBS J 2008;275:1025-38.
23. Neale G, Lewis B, Weaver V, Panveliwalla D. Serum bile acids in liver disease. Gut 1971;12:145-52.
24. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment ofHigh Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002;106:3143-421.
25. Cao XH, Liu W, Lin F, Li H, Kolluri SK, Lin BZ, et al. Retinoid X receptor regulates Nur77/thyroid hormone receptor 3-dependent apoptosis by modulating its nuclear export and mitochondrial targeting. Mol Cell Biol 2004;24:9705-25.
26. Payne CM, Crowley C, Washo-Stultz D, BriehlM, Bernstein H, Bernstein C, et al. The stress-response proteins poly(ADP-ribose) polymerase and NF-κB protect against bile salt-induced apoptosis. Cell Death Differ 1998;5:623-36.
27. Washo-Stultz D, Crowley-Weber CL, Dvorakova K, Bernstein C, Bernstein H, Kunke K, et al. Role of mitochondrial complexes I and II, reactive oxygen species and arachidonic acid metabolism in deoxycholate-induced apoptosis. Cancer Lett 2002;177:129-44.
28. Payne CM, Weber C, Crowley-Skillicorn C, Dvorak K, Bernstein H, Bernstein C, et al. Deoxycholate induces mitochondrial oxidative stress and activates NF-κB through multiple mechanisms in HCT-116 colon epithelial cells. Carcinogenesis 2007;28:215-22.
29. Pei LM, Castrillo A, Chen MY, Hoffmann A, Tontonoz P. Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli. J Biol Chem 2005;280:29256-62.
30. Wu H, Lin Y, Li W, Sun Z, Gao W, Zhang H, et al. Regulation of Nur77 expression by beta-catenin and its mitogenic effect in colon cancer cells. FEBS J 2011;25:192-205.
31. Mu XM, Chang CS. TR3 orphan nuclear receptor mediates apoptosis through up-regulating E2F1 in human prostate cancer LNCaP cells. J Biol Chem 2003;278:42840-5.
32. Yao LM, He JP, Chen HZ, Wang Y, Wang WJ, Wu R, et al. Orphan receptor TR3 participates in cisplatin-induced apoptosis via Chk2 phosphorylation to repress intestinal tumorigenesis. Carcinogenesis 2012;33:301-11.
33. Pei L, Waki H, Vaitheesvaran B, Wilpitz DC, Kurland IJ, Tontonoz P. NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism. Nat Med 2006;12:1048-55.
34. Kang SA, Na H, Kang HJ, Kim SH, Lee MH, Lee MO. Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1. Biochem Pharmacol 2010;80:867-73.