Long-term imipramine treatment increases N-methyl-d-aspartate receptor activity and expression via epigenetic mechanisms

European Journal of Pharmacology

Volumn 752, Issue , 2015, Pages 69-77

  Nghia, Nguyen An ^a   Hirasawa, Takae ^a,b,c   Kasai, Hirotake ^a   Obata, Chie ^a,b   Moriishi, Kohji ^a   Mochizuki, Kazuki ^a   Koizumi, Schuichi ^a   Kubota, Takeo ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TEIKYO UNIVERSITY   (Japan)

Author keywords

Epigenetics; Histone acetylation; Imipramine; Neocortical neuron; NMDA receptor; NR2B

Indexed keywords

AMPA RECEPTOR; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 11; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE 5; HISTONE H3; IMIPRAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL; ANTIDEPRESSANT AGENT; CALCIUM; HISTONE; NR2B NMDA RECEPTOR;

ANIMAL CELL; ARTICLE; BRAIN CELL; CALCIUM TRANSPORT; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; EPIGENETICS; FETUS; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; HISTONE ACETYLATION; IC50; IN VITRO STUDY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION SITE; TREATMENT DURATION; UPREGULATION; ACETYLATION; ANIMAL; CYTOLOGY; DRUG EFFECTS; GENETIC EPIGENESIS; GENETICS; METABOLISM; NEOCORTEX; NERVE CELL; TIME; TRANSPORT AT THE CELLULAR LEVEL;

ACETYLATION; ANIMALS; ANTIDEPRESSIVE AGENTS; BIOLOGICAL TRANSPORT; CALCIUM; EPIGENESIS, GENETIC; HISTONES; IMIPRAMINE; MICE; NEOCORTEX; NEURONS; PROMOTER REGIONS, GENETIC; RECEPTORS, N-METHYL-D-ASPARTATE; TIME FACTORS;

EID: 84923885175     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.02.010     Document Type: Article

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