AMPA induced Ca2+ influx in motor neurons occurs through voltage gated Ca2+ channel and Ca2+ permeable AMPA receptor

Neurochemistry International

Volumn 59, Issue 6, 2011, Pages 913-921

  Joshi, Dinesh C ^a   Singh, Mahendra ^a   Krishnamurthy, Karthik ^a   Joshi, Preeti G ^a   Joshi, Nanda B ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

AMPA receptors; Amyotrophic lateral sclerosis; Calcium signaling; Excitotoxicity; Mitochondrial calcium; Motor neurons; Voltage gated calcium channels

Indexed keywords

1 NAPHTHYL ACETYL SPERMINE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; CALCIUM ANTAGONIST; NIFEDIPINE; OMEGA AGATOXIN IVA; OMEGA AGATOXIN VIA; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; CALCIUM CHANNEL; CALCIUM CHANNEL L TYPE;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; EMBRYO; INTRACELLULAR SIGNALING; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; MOTONEURON; NERVE CELL DEGENERATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM TRANSPORT; SPINAL CORD NERVE CELL; VOLTAGE CLAMP; ANIMAL; CALCIUM SIGNALING; CELL MEMBRANE PERMEABILITY; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; PHYSIOLOGY; PRIMARY CELL CULTURE; SPINAL CORD; SPRAGUE DAWLEY RAT;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CELL MEMBRANE PERMEABILITY; MOTOR NEURONS; PRIMARY CELL CULTURE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; SPINAL CORD;

EID: 80255138209     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2011.06.023     Document Type: Article

References (33)

1. Y. Arakawa, C. Nishijima, N. Shimizu, and T. Urushidani Survival promoting activity of nimodipine and nifedipine in rat motoneurons: implications of an intrinsic calcium toxicity in motoneurons J. Neurochem. 83 2002 150 156
2. O. Bar-Peled, R.J. O'Brien, J.H. Morrison, and J.D. Rothstein Cultured motor neurons possess calcium-permeable AMPA/kainate receptors NeuroReport 10 1999 855 859 (Pubitemid 29393835)
3. R. Brusa, F. Zimmerman, D.S. Koh, D. Feldmeyer, P. Gass, P.H. Seeburg, and R. Sprengel Early onset epilepsy and postnatal lethality associated with an editing deficient GluR-B allele in mice Science 270 1995 1677 1680 (Pubitemid 26002446)
4. S.G. Carriedo, H.Z. Yin, and J.H. Weiss Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro J. Neurosci. 16 1996 4069 4079 (Pubitemid 26192403)
5. 2+ determine motoneuron vulnerability in rat spinal cord in vivo Neuropharmacology 52 2007 1219 1228 (Pubitemid 46527697)
6. D.W. Cleveland, and J.D. Rothstein From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS Nat. Rev. Neurosci. 2 2001 806 819 (Pubitemid 33674062)
7. K. Duncan The role of AMPA-receptor mediated excitotoxicity in ALS: is deficient RNA editing to blame? Curr. Anaesth. Crit. Care 20 2009 227 235
8. H.J. Fryer, R.J. Knox, S.M. Strittmatter, and R.G. Kalb Excitotoxic death of a subset of embryonic rat motor neurons in vitro J. Neurochem. 72 1999 500 513 (Pubitemid 29055211)
9. A. Greig, S.D. Donevan, T.J. Mujtaba, T.N. Parks, and M.S. Rao Characterization of the AMPA-activated receptors present on motoneurons J. Neurochem. 74 2000 179 191 (Pubitemid 30012768)
10. 2+ indicators with greatly improved fluorescent properties J. Biol. Chem. 260 1985 3440 3450 (Pubitemid 15114340)
11. 2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition Science 252 1991 851 853 (Pubitemid 121000528)
12. Z. Jia, N. Agopyan, M.P. Xiongz, J. Henderson, R. Gerlai, F.A. Taverna, A. Velumian, J. MacDonald, P. Carlen, W. Abramov-Newerly, and J. Roger Enhanced LTP in mice deficient in AMPA receptorGluR2 Neuron 34 1996 759 772
13. Y. Kawahara, and S. Kwak Excototoxicity and ALS: what is unique about the AMPA receptors expressed on spinal neurons? Amyotroph. Lateral Scler. 6 2005 131 144 (Pubitemid 41419200)
14. L. Kiedrowski, J.T. Wroblewski, and E. Coast Intracellular sodium concentration in cultured cerebellar granule cells challenged with glutamate Mol. Pharm. 45 1994 1050 1054 (Pubitemid 24155799)
15. V. Le Verche, B. Ikiz, A. Jacquier, S. Przedborski, and B. Re D Glutamate pathways implication in amyotrophic lateral sclerosis: what is the signal in the noise? J. Recept. Ligang Channel Res. 4 2011 1 22
16. M. Lino, S. Ozawa, and K. Tsuzuki Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurons J. Physiol. 424 1990 151 165 (Pubitemid 20175151)
17. J.G. Mc Cormack, A.P. Halestrap, and R.M. Denton Role of calcium ions in regulation of mammalian intramitochondrial metabolism Physiol. Rev. 70 1990 391 425 (Pubitemid 20140186)
18. A.K. Minta, and R. Tsien Fluorescent indicators for cytosolic sodium J. Biol. Chem. 264 1989 19449 19457 (Pubitemid 19285857)
19. C.L. Palmer, L. Cotton, and J.M. Heneley The molecular pharmacology and cell biology of α-amoni-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors Pharmacol. Rev. 57 2005 253 277 (Pubitemid 41043886)
20. T.I. Peng, M.J. Jou, and T. Greenamare Privileged access to mitochondria of calcium influx through NMDA receptors Mol. Pharma. 53 1998 974 980
21. R. Sattler, M.P. Charlton, M. Hafner, and M. Tymianski Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity J. Neurochem. 7 1998 2349 2364 (Pubitemid 28531245)
22. A.E. Schaffner, P.A. St. John, and J.L. Barker Fluorescence activated cell sorting of embryonic mouse and rat motor neurons and their long term survival in vitro J. Neurosci. 7 1987 3088 3104
23. I. Sen, A. Nalini, N.B. Joshi, and P.G. Joshi Cerebrospinal fluid from amyotrophic lateral sclerosis patients preferentially elevates intracellular calcium and toxicity in motor neurons via AMPA/kainate receptor J. Neurol. Sci. 235 2005 45 54 (Pubitemid 41039092)
24. 2+ load and greater vulnerability of motor neurons in spinal cord cultures Neurochem. Int. 52 2008 247 255 (Pubitemid 350235697)
25. N.J. Solenski, V.K. Kostecki, S. Dovey, and A. Periasamy Nitric-oxide-induced depolarization of neuronal mitochondria: implications for neuronal cell death Mol. Cell. Neurosci. 24 2003 1151 1169 (Pubitemid 38091523)
26. 2+ signaling Physiology 23 2008 84 94
27. M. Tymianski, M.P. Charlton, P.L. Carlen, and C.H. Tator Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons J. Neurosci. 13 1993 2085 2104 (Pubitemid 23113418)
28. 2+ - permeable AMPA receptors and selective vulnerability of motor neurons J. Neurological. Sci. 180 2000 29 34
29. P. Van Damme, M. Dewil, L. Van Den Bosch, E. Van Houtte, G. Callewaert, and W. Robberecht GluR2 dependent properties of AMPA receptors determine the selective vulnerability of motor neurons to excitotoxicity J. Neurophysiol. 88 2002 1279 1287 (Pubitemid 35025382)
30. W. Vandenberghe, W. Robberecht, and J.R. Brorson AMPA receptor calcium permeability, GluR2 expression, and selective motor neuron vulnerability J. Neurosci. 20 2000 123 132 (Pubitemid 30220498)
31. W. Vandenberghe, E.C. Ihle, D.K. Patneau, W. Robberecht, and J.R. Brorson AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability J. Neurosci. 20 2000 7158 7166
32. W. Vandenberghe, V.P. Bindokas, R.J. Miller, W. Robberecht, and J.R. Brorson Subcellular localization of calcium permeable AMPA receptors in spinal motoneurons Euro. J. Neurosci. 14 2001 305 314 (Pubitemid 32777636)
33. T.L. Williams, N.C. Day, P.G. Ince, R.K. Kamboj, and P.J. Shaw Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors: a molecular determinant of selective vulnerability in amyotrophic lateral sclerosis Ann. Neurol. 42 1997 200 207 (Pubitemid 27340465)