Absence of intracellular ion channels TPC1 and TPC2 leads to mature-onset obesity in male mice, due to impaired lipid availability for thermogenesis in brown adipose tissue

Endocrinology (United States)

Volumn 156, Issue 3, 2015, Pages 975-986

  Lear, Pamela V ^a,c   González Touceda, David ^a,d   Couto, Begoña Porteiro ^a,d   Viaño, Patricia ^a,b   Guymer, Vanessa ^e   Remzova, Elena ^f   Tunn, Ruth ^c   Chalasani, Annapurna ^f   García Caballero, Tomás ^a,b   Hargreaves, Iain P ^f   Tynan, Patricia W ^c   Christian, Helen C ^e   Nogueiras, Rubén ^a,d   Parrington, John ^c,e   Diéguez, Carlos ^a,b,d  

^a Instituto de Salud Carlos III   (Spain)

^b University of Santiago de Compostela and Institute of Health Sciences ^*  (Spain)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d Instituto de Salud Carlos III   (Spain)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; CYTOCHROME C OXIDASE; FATTY ACID; FIBROBLAST GROWTH FACTOR 21; G PROTEIN COUPLED RECEPTOR KINASE 3; HORMONE SENSITIVE LIPASE; LIPID; PROTEIN; TRIACYLGLYCEROL LIPASE; TWO PORE CHANNEL 1 PROTEIN; TWO PORE CHANNEL 2 PROTEIN; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; AGINACTIN PROTEIN, DICTYOSTELIUM; CALCIUM CHANNEL; PROTOZOAL PROTEIN; TPCN1 PROTEIN, MOUSE; TPCN2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BODY MASS; BROWN ADIPOSE TISSUE; CALCIUM CELL LEVEL; CALORIMETRY; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENERGY BALANCE; EXPERIMENTAL OBESITY; FATTY ACID BLOOD LEVEL; FOOD INTAKE; LOCOMOTION; MALE; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY CHAIN; RESPIRATORY QUOTIENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THERMOGENESIS; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; LIPID METABOLISM; METABOLISM; OBESITY; PHYSIOLOGY; SIGNAL TRANSDUCTION; THERMOREGULATION;

ADIPOSE TISSUE, BROWN; ANIMALS; BODY TEMPERATURE REGULATION; CALCIUM CHANNELS; GENE EXPRESSION REGULATION; LIPID METABOLISM; MALE; MICE; MICE, KNOCKOUT; OBESITY; PROTOZOAN PROTEINS; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION;

EID: 84923884834     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2014-1766     Document Type: Article

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