The central sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin

Diabetes

Volumn 60, Issue 4, 2011, Pages 1177-1185

  Velásquez, Douglas A ^a,b   Martínez, Gloria ^a   Romero, Amparo ^a,b   Vázquez, María J ^a,b   Boit, Katia D ^a,b,c   Dopeso Reyes, Iria G ^b   López, Miguel ^a,b   Vidal, Anxo ^a   Nogueiras, Ruben ^a,b   Diéguez, Carlos ^a,b  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c Catarinense Institut of Environmental Research and Human Development   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; EX 52; GHRELIN; HYDROLASE INHIBITOR; NEUROPEPTIDE; PROTEIN P53; SIRTINOL; SIRTUIN 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CALORIC RESTRICTION; DRUG ACTIVITY; FEEDING BEHAVIOR; FOOD INTAKE; GROWTH HORMONE RELEASE; IN SITU HYBRIDIZATION; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; NUTRITIONAL ASSESSMENT; NUTRITIONAL STATUS; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; WESTERN BLOTTING;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BENZAMIDES; BLOTTING, WESTERN; CARBAZOLES; EATING; FEEDING BEHAVIOR; GHRELIN; IN SITU HYBRIDIZATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NAPHTHOLS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; SIRTUIN 1; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79953183390     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-0802     Document Type: Article

References (39)

1. Tschöp M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000;407:908-913
2. Theander-Carrillo C, Wiedmer P, Cettour-Rose P, et al. Ghrelin action in the brain controls adipocyte metabolism. J Clin Invest 2006;116:1983-1993 (Pubitemid 44033322)
3. Egecioglu E, Jerlhag E, Salomé N, et al. Ghrelin increases intake of rewarding food in rodents. Addict Biol 2010;15:304-311
4. Kola B, Farkas I, Christ-Crain M, et al. The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. PLoS One 2008;3:e1797
5. Andrews ZB, Liu ZW, Walllingford N, et al. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 2008;454: 846-851
6. López M, Lage R, Saha AK, et al. Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab 2008;7:389-399 (Pubitemid 351618114)
7. Picard F, Kurtev M, Chung N, et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 2004;429:771-776 (Pubitemid 38833129)
8. Rodgers JT, Puigserver P. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci USA 2007;104:12861-12866 (Pubitemid 47255245)
9. Bordone L, Motta MC, Picard F, et al. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol 2006;4:e31
10. Cantó C, Gerhart-Hines Z, Feige JN, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 2009; 458:1056-1060
11. Ramadori G, Lee CE, Bookout AL, et al. Brain SIRT1: anatomical distribution and regulation by energy availability. J Neurosci 2008;28:9989-9996
12. Cohen DE, Supinski AM, Bonkowski MS, Donmez G, Guarente LP. Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. Genes Dev 2009;23:2812-2817
13. Cakir I, Perello M, Lansari O, Messier NJ, Vaslet CA, Nillni EA. Hypothalamic Sirt1 regulates food intake in a rodent model system. PLoS One 2009;4:e8322
14. Dietrich MO, Antunes C, Geliang G, et al. Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity. J Neurosci 2010;30:11815-11825
15. Satoh A, Brace CS, Ben-Josef G, et al. SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. J Neurosci 2010;30:10220-10232
16. Sasaki T, Kim HJ, Kobayashi M, et al. Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide. Endocrinology 2010;151:2556-2566
17. Ramadori G, Fujikawa T, Fukuda M, et al. SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metab 2010;12:78-87
18. Vousden KH, Ryan KM. p53 and metabolism. Nat Rev Cancer 2009;9:691-700
19. Jacks T, Remington L, Williams BO, et al. Tumor spectrum analysis in p53- mutant mice. Curr Biol 1994;4:1-7
20. Nogueiras R, Wiedmer P, Perez-Tilve D, et al. The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest 2007;117:3475-3488 (Pubitemid 350097003)
21. Nogueiras R, Pérez-Tilve D, Veyrat-Durebex C, et al. Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. J Neurosci 2009;29:5916-5925
22. Solomon JM, Pasupuleti R, Xu L, et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol 2006;26:28-38
23. Ota H, Tokunaga E, Chang K, et al. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene 2006;25:176-185 (Pubitemid 43083679)
24. Nogueiras R, López M, Lage R, et al. Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability. Endocrinology 2008;149:3009-3015 (Pubitemid 351724518)
25. Seoane LM, López M, Tovar S, Casanueva FF, Señarís R, Diéguez C. Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus. Endocrinology 2003;144:544-551 (Pubitemid 36205226)
26. Paxinos GW. The Rat Brain in Stereotaxic Coordinates. Sydney, Academic Press, 1986
27. Seoane LM, Tovar S, Baldelli R, et al. Ghrelin elicits a marked stimulatory effect on GH secretion in freely-moving rats. Eur J Endocrinol 2000;143: R7-R9
28. Kim EJ, Kho JH, Kang MR, Um SJ. Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. Mol Cell 2007;28:277-290
29. Nakazato M, Murakami N, Date Y, et al. A role for ghrelin in the central regulation of feeding. Nature 2001;409:194-198 (Pubitemid 32144284)
30. Han MK, Song EK, Guo Y, Ou X, Mantel C, Broxmeyer HE. SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. Cell Stem Cell 2008;2:241-251 (Pubitemid 351298591)
31. Hallenborg P, Feddersen S, Madsen L, Kristiansen K. The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function. Expert Opin Ther Targets 2009;13:235-246
32. Andersson U, Filipsson K, Abbott CR, et al. AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem 2004;279:12005-12008 (Pubitemid 38445761)
33. Cohen HY, Miller C, Bitterman KJ, et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004;305:390-392 (Pubitemid 38938153)
34. Kirchner H, Gutierrez JA, Solenberg PJ, et al. GOAT links dietary lipids with the endocrine control of energy balance. Nat Med 2009;15:741-745
35. Prudom C, Liu J, Patrie J, et al. Comparison of competitive radioi-mmunoassays and two-site sandwich assays for the measurement and interpretation of plasma ghrelin levels. J Clin Endocrinol Metab 2010;95:2351-2358
36. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656-660 (Pubitemid 129516334)
37. Zigman JM, Jones JE, Lee CE, Saper CB, Elmquist JK. Expression of ghrelin receptor mRNA in the rat and the mouse brain. J Comp Neurol 2006;494:528-548 (Pubitemid 41791000)
38. Dasgupta B, Milbrandt J. Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci USA 2007;104:7217-7222 (Pubitemid 47186035)
39. Nemoto S, Fergusson MM, Finkel T. Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science 2004;306:2105-2108 (Pubitemid 40007664)