Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors

Journal of Medicinal Chemistry

Volumn 58, Issue 4, 2015, Pages 1964-1975

  Morgan, Cynthia A ^a   Hurley, Thomas D ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; ALDEHYDE DEHYDROGENASE INHIBITOR; ALDEHYDE DEHYDROGENASE ISOENZYME 1; ALDEHYDE DEHYDROGENASE ISOENZYME 1A1 INHIBITOR; GLYCINE; ISOENZYME; UNCLASSIFIED DRUG; ALDEHYDE DEHYDROGENASE; ALDH1A1 PROTEIN, HUMAN; ENZYME INHIBITOR;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOSE RESPONSE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; HYDROGEN BOND; INHIBITION CONSTANT; SEQUENCE ALIGNMENT; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; DEFICIENCY; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; MOUSE; SYNTHESIS;

ALDEHYDE DEHYDROGENASE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; ISOENZYMES; MICE; MICE, KNOCKOUT; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84923863027     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501900s     Document Type: Article

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