Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity

ChemBioChem

Volumn 15, Issue 5, 2014, Pages 701-712

  Parajuli, Bibek ^a   Georgiadis, Taxiarchis M ^b   Fishel, Melissa L ^a   Hurley, Thomas D ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

cancer chemoresistance; enzyme; inhibitors; kinetics; X ray crystallography

Indexed keywords

ALDEHYDE; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 3A1; ALDEHYDE DEHYDROGENASE INHIBITOR; CB 29; MAFOSFAMIDE; UNCLASSIFIED DRUG; ALDH1A1 PROTEIN, HUMAN; ALDH3A1 PROTEIN, HUMAN; ALDOPHOSPHAMIDE; ALKYLATING AGENT; CYCLOPHOSPHAMIDE; ENZYME INHIBITOR; PHOSPHORAMIDE MUSTARD;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CARCINOMA CELL; CELL PROLIFERATION; CHEMOSENSITIVITY; CHEMOSENSITIZATION; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG BINDING SITE; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; LUNG FIBROBLAST; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR DOCKING; NEOPLASMS; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

ALDEHYDE DEHYDROGENASE; ANTINEOPLASTIC AGENTS, ALKYLATING; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; CYCLOPHOSPHAMIDE; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MOLECULAR DOCKING SIMULATION; NEOPLASMS; PHOSPHORAMIDE MUSTARDS;

EID: 84896397225     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201300625     Document Type: Article

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