Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases

Journal of Biological Chemistry

Volumn 286, Issue 50, 2011, Pages 43486-43494

  Khanna, May ^a   Chen, Che Hong ^b   Kimble Hill, Ann ^a   Parajuli, Bibek ^a   Perez Miller, Samantha ^a   Baskaran, Sulochanadevi ^a   Kim, Jeewon ^b   Dria, Karl ^c   Vasiliou, Vasilis ^d   Mochly Rosen, Daria ^b   Hurley, Thomas D ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INDIANA UNIVERSITY   (United States)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ALDEHYDE DEHYDROGENASE; CELLULAR PHENOTYPES; CRYSTALLOGRAPHIC ANALYSIS; CYSTEINE RESIDUES; ELIMINATION REACTION; GENERAL CLASS; KINETIC STUDY; MECHANISM OF ACTION; METABOLIC PATHWAYS; RESEARCH TOOLS; SPECTROMETRIC MEASUREMENTS; VINYL KETONES;

ALDEHYDES; AMINO ACIDS; ENZYMES; KETONES; REACTION INTERMEDIATES;

ORGANIC COMPOUNDS;

1 (4 CHLOROPHENYL) 3 (1 PIPERIDINYL) 1 PROPANONE; 3 (1 AZEPENYL) 1 PHENYL 1 PROPANONE; 3 (DIMETHYLAMINO) 1 (3 FLUORO 4 METHOXYPHENYL) 1 PROPANONE; 3 (DIMETHYLAMINO) 1 (4 ETHYLPHENYL) 1 PROPANONE; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE INHIBITOR; ALDEHYDE DEHYDROGENASE ISOENZYME 1A1; ALDEHYDE DEHYDROGENASE ISOENZYME 2; ALDEHYDE DEHYDROGENASE ISOENZYME 3A1; CASPASE 6; CYSTEINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; IC 50; MASS SPECTROMETRY; MOLECULAR CLONING; PHENOTYPE; PRIORITY JOURNAL;

ALDEHYDE DEHYDROGENASE; ALDEHYDES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYCLOPHOSPHAMIDE; ENZYME INHIBITORS; HUMANS; KINETICS; MASS SPECTROMETRY; MOLECULAR STRUCTURE; PROTEIN STRUCTURE, SECONDARY;

EID: 83355174070     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.293597     Document Type: Article

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