Blood-borne viruses in health care workers: Prevention and management

Journal of Clinical Virology

Volumn 52, Issue 1, 2011, Pages 4-10

  Deuffic Burban, S ^a   Delarocque Astagneau, E ^b   Abiteboul, D ^c,d   Bouvet, E ^c,d   Yazdanpanah, Y ^a,c,e  

^a UNIV LILLE   (France)

^b INSTITUT PASTEUR   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d BICHAT HOSPITAL   (France)

^e CENTRE HOSPITALIER DE TOURCOING   (France)

Author keywords

Blood borne pathogens; Infectious disease transmission; Management risk; Patient to professional; Prevention and control; Professional to patient

Indexed keywords

ANTIRETROVIRUS AGENT; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE;

BLOODBORNE BACTERIUM; BLOODSTREAM INFECTION; COMPLIANCE (PHYSICAL); FLAVIVIRUS INFECTION; HEALTH CARE FACILITY; HEALTH CARE PERSONNEL; HEPADNAVIRUS INFECTION; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNIZATION; INFECTION RISK; NEEDLE; NONHUMAN; OCCUPATIONAL EXPOSURE; POST EXPOSURE PROPHYLAXIS; PRIORITY JOURNAL; REVIEW; SURGEON; SYRINGE; VASCULAR ACCESS; VIRUS INFECTION; VIRUS TRANSMISSION;

BLOOD-BORNE PATHOGENS; HUMANS; INFECTIOUS DISEASE TRANSMISSION, PATIENT-TO-PROFESSIONAL; OCCUPATIONAL DISEASES; PATIENT CARE TEAM;

EID: 79961126149     PISSN: 13866532     EISSN: 18735967     Source Type: Journal    
DOI: 10.1016/j.jcv.2011.05.016     Document Type: Review

References (72)

1. Tarantola A., Abiteboul D., Rachline A. Infection risks following accidental exposure to blood or body fluids in health care workers: a review of pathogens transmitted in published cases. Am J Infect Control 2006, 34:367-375.
2. Pruss-Ustun A., Rapiti E., Hutin Y. Estimation of the global burden of disease attributable to contaminated sharps injuries among health-care workers. Am J Ind Med 2005, 48:482-490.
3. Yazdanpanah Y., De Carli G., Migueres B., Lot F., Campins M., Colombo C., et al. Risk factors for hepatitis C virus transmission to health care workers after occupational exposure: a European case-control study. Clin Infect Dis 2005, 41:1423-1430.
4. Hosoglu S., Celen M.K., Akalin S., Geyik M.F., Soyoral Y., Kara I.H. Transmission of hepatitis C by blood splash into conjunctiva in a nurse. Am J Infect Control 2003, 31:502-504.
5. Ippolito G., Puro V., Petrosillo N., De Carli G., Micheloni G., Magliano E. Simultaneous infection with HIV and hepatitis C virus following occupational conjunctival blood exposure. JAMA 1998, 280:28.
6. Sartori M., La Terra G., Aglietta M., Manzin A., Navino C., Verzetti G. Transmission of hepatitis C via blood splash into conjunctiva. Scand J Infect Dis 1993, 25:270-271.
7. FitzSimons D., Francois G., De Carli G., Shouval D., Pruss-Ustun A., Puro V., et al. Hepatitis B virus, hepatitis C virus and other blood-borne infections in healthcare workers: guidelines for prevention and management in industrialised countries. Occup Environ Med 2008, 65:446-451.
8. Wicker S., Jung J., Allwinn R., Gottschalk R., Rabenau H.F. Prevalence and prevention of needlestick injuries among health care workers in a German university hospital. Int Arch Occup Environ Health 2008, 81:347-354.
9. Alamgir H., Cvitkovich Y., Astrakianakis G., Yu S., Yassi A. Needlestick and other potential blood and body fluid exposures among health care workers in British Columbia, Canada. Am J Infect Control 2008, 36:12-21.
10. Hofmann F., Kralj N., Beie M. Needle stick injuries in health care-frequency, causes und preventive strategies. Gesundheitswesen 2002, 64:259-266.
11. Deisenhammer S., Radon K., Nowak D., Reichert J. Needlestick injuries during medical training. J Hosp Infect 2006, 63:263-267.
12. Jagger J., Puro V., De Carli G. Occupational transmission of hepatitis C virus. JAMA 2002, 288:1469. [author reply -71].
13. Cardo D.M., Culver D.H., Ciesielski C.A., Srivastava P.U., Marcus R., Abiteboul D., et al. A case-control study of HIV seroconversion in health care workers after percutaneous exposure. Centers for Disease Control and Prevention Needlestick Surveillance Group. N Engl J Med 1997, 337:1485-1490.
14. Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in health-care settings. MMWR Morb Mortal Wkly Rep 1988;37:377-82,87-8.
15. Schmid K., Schwager C., Drexler H. Needlestick injuries and other occupational exposures to body fluids amongst employees and medical students of a German university: incidence and follow-up. J Hosp Infect 2007, 65:124-130.
16. Jagger J. Caring for healthcare workers: a global perspective. Infect Control Hosp Epidemiol 2007, 28:1-4.
17. RAISIN. Surveillance des accidents avec exposition au sang dans les établissements de santé français en 2004. Saint-Maurice: Institut de veille sanitaire; 2005.
18. RAISIN. Surveillance des accidents avec exposition au sang dans les établissements de santé français en 2006. Saint-Maurice: Institut de veille sanitaire; 2008.
19. RAISIN. Surveillance des accidents avec exposition au sang dans les établissements de santé français en 2008 - Résultats. Saint-Maurice: Institut de veille sanitaire; 2011.
20. National surveillance of accidental blood exposure in Belgian hospitals. Available from: 2010 [cited 06.05.11]. http://www.nsih.be/surv_prik/Cumulative%20Report20032009.pdf.
21. Perry J, Parker G, Jagger J. EPINet Report: 2004 Percutaneous Injury Rates. Available from: 2007 [cited 06.05.11]. http://healthsystem.virginia.edu/internet/epinet/EPINet-2004-rates.pdf.
22. Perry J, Parker G, Jagger J. EPINet Report: 2006 Percutaneous Injury Rates. Available from: 2009 [cited 06.05.11]. http://healthsystem.virginia.edu/internet/epinet/2006EPINetreport.pdf.
23. Valls V., Lozano M.S., Yanez R., Martinez M.J., Pascual F., Lloret J., et al. Use of safety devices and the prevention of percutaneous injuries among healthcare workers. Infect Control Hosp Epidemiol 2007, 28:1352-1360.
24. Whitby M., McLaws M.L., Slater K. Needlestick injuries in a major teaching hospital: the worthwhile effect of hospital-wide replacement of conventional hollow-bore needles. Am J Infect Control 2008, 36:180-186.
25. Lamontagne F., Abiteboul D., Lolom I., Pellissier G., Tarantola A., Descamps J.M., et al. Role of safety-engineered devices in preventing needlestick injuries in 32 French hospitals. Infect Control Hosp Epidemiol 2007, 28:18-23.
26. Tosini W., Ciotti C., Goyer F., Lolom I., L'Heriteau F., Abiteboul D., et al. Needlestick injury rates according to different types of safety-engineered devices: results of a French multicenter study. Infect Control Hosp Epidemiol 2010, 31:402-407.
27. Use of Blunt-Tip Suture Needles to Decrease Percutaneous Injuries to Surgical Personnel: Safety and Health Information Bulletin Available from: [cited 05.02.10]. http://www.cdc.gov/niosh/docs/2008-101/.
28. Puro V., De Carli G., Cicalini S., Soldani F., Balslev U., Begovac J., et al. European recommendations for the management of healthcare workers occupationally exposed to hepatitis B virus and hepatitis C virus. Euro Surveill 2005, 10:260-264.
29. Lettau L.A., Alfred H.J., Glew R.H., Fields H.A., Alter M.J., Meyer R., et al. Nosocomial transmission of delta hepatitis. Ann Intern Med 1986, 104:631-635.
30. Dannetun E., Tegnell A., Torner A., Giesecke J. Coverage of hepatitis B vaccination in Swedish healthcare workers. J Hosp Infect 2006, 63:201-204.
31. Calendrier vaccinal 2008. Avis du Haut conseil de la santé publique. Vaccination schedule for 2008. Recommendations from the "Haut conseil de la santé publique" Bull Epidemiol Hebd 2008;16-17:129-47.
32. Zuckerman J.N. Protective efficacy, immunotherapeutic potential, and safety of hepatitis B vaccines. J Med Virol 2006, 78:169-177.
33. Kubba A.K., Taylor P., Graneek B., Strobel S. Non-responders to hepatitis B vaccination: a review. Commun Dis Public Health 2003, 6:106-112.
34. Arrêté du 6 mars 2007 fixant les conditions d'immunisation des personnes visées à l'article L. 3111-4 du code de la santé publique; 2007. Available from: [cited 08.03.10]. http://www.legifrance.org/rechExpTexteJorf.do%3Freprise=true%26page=1.
35. Struve J., Aronsson B., Frenning B., Forsgren M., Weiland O. Seroconversion after additional vaccine doses to non-responders to three doses of intradermally or intramuscularly administered recombinant hepatitis B vaccine. Scand J Infect Dis 1994, 26:468-470.
36. Poland G.A. Hepatitis B immunization in health care workers. Dealing with vaccine nonresponse. Am J Prev Med 1998, 15:73-77.
37. Landovitz R.J., Currier J.S. Clinical practice. Postexposure prophylaxis for HIV infection. N Engl J Med 2009, 361:1768-1775.
38. EASL international consensus conference on hepatitis B. J Hepatol 2003, 38:533-540. [consensus statement (short version)].
39. Weinbaum C., Lyerla R., Margolis H.S. Prevention and control of infections with hepatitis viruses in correctional settings. Centers for Disease Control and Prevention. MMWR Recomm Rep 2003, 52:1-36. [quiz CE1-4].
40. Department of Health and Human Services CfDCaP. Updated US Public Health Service guidelines for the management of occupational exposure to HBV, HCV, and HIV and recommendations for post exposure prophylaxis. MMWR Morb Mortal Wkly Rep 2001;50:1-42.
41. Ministère de la santé, de la jeunesse et des sports, Ministère du travail, des relations sociales et de la solidarité. Circulaire interministérielle N° DGS/R12/DHOS/DGT/DSS/2008/91 du 13 mars 2008 relative aux recommandations de prise en charge des personnes exposées à un risque de transmission du virus de l'immunodéficience humaine (VIH). Bull Epidemiol Hebd 2008;1-12. Available from: [cited 22.04.08]. http://www.sante.gouv.fr/adm/dagpb/bo/2008/08-05/ste_20080005_0100_0079.pdf.
42. Deuffic-Burban S., Abiteboul D., Lot F., Branger M., Bouvet E., Yazdanpanah Y. Costs and cost-effectiveness of different follow-up schedules for detection of occupational hepatitis C virus infection. Gut 2009, 58:105-110.
43. Strader D.B., Wright T., Thomas D.L., Seef L.B. Diagnosis, management, and treatment of hepatitis C. Hepatology 2004, 39:1147-1171.
44. Deuffic-Burban S., Castel H., Wiegand J., Manns M.P., Wedemeyer H., Mathurin P., et al. Immediate versus delayed treatment in patients with acute hepatitis C: a model-based decision analysis. Hepatology 2009, 50:666A.
45. Puro V., Cicalini S., De Carli G., Soldani F., Ippolito G. Towards a standard HIV post exposure prophylaxis for healthcare workers in Europe. Eur Surveill 2004, 9:40-43.
46. Department of Health and Human Services CfDCaP. Updated US Public Health Service guidelines for the management of occupational exposure to HIV and recommendations for post exposure prophylaxis. MMWR Morb Mortal Wkly Rep 2005;54:1-17.
47. Yeni P. Rapport 2008. Prise en charge médicale des personnes infectées par le VIH. Recommandations du groupe d'experts 2008, Médecine-Sciences Flammarion, Paris.
48. Tsai C.C., Follis K.E., Sabo A., Beck T.W., Grant R.F., Bischofberger N., et al. Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine. Science 1995, 270:1197-1199.
49. Tsai C.C., Emau P., Follis K.E., Beck T.W., Benveniste R.E., Bischofberger N., et al. Effectiveness of postinoculation (R)-9-(2-phosphonylmethoxypropyl) adenine treatment for prevention of persistent simian immunodeficiency virus SIVmne infection depends critically on timing of initiation and duration of treatment. J Virol 1998, 72:4265-4273.
50. Otten R.A., Smith D.K., Adams D.R., Pullium J.K., Jackson E., Kim C.N., et al. Efficacy of postexposure prophylaxis after intravaginal exposure of pig-tailed macaques to a human-derived retrovirus (human immunodeficiency virus type 2). J Virol 2000, 74:9771-9775.
51. Fiscus S.A., Schoenbach V.J., Wilfert C. Short courses of zidovudine and perinatal transmission of HIV. New Engl J Med 1999, 340:1040-1041. author reply 2-3.
52. Wade N.A., Birkhead G.S., Warren B.L., Charbonneau T.T., French P.T., Wang L., et al. Abbreviated regimens of zidovudine prophylaxis and perinatal transmission of the human immunodeficiency virus. New Engl J Med 1998, 339:1409-1414.
53. Henderson D.K., Dembry L., Fishman N.O., Grady C., Lundstrom T., Palmore T.N., et al. SHEA guideline for management of healthcare workers who are infected with hepatitis B virus, hepatitis C virus, and/or human immunodeficiency virus. Infect Control Hosp Epidemiol 2010, 31:203-232.
54. Perry J.L., Pearson R.D., Jagger J. Infected health care workers and patient safety: a double standard. Am J Infect Control 2006, 34:313-319.
55. Health Service Circular 2002/010-Hepatitis C infected health care workers. Available from: [cited 16.02.10]. http://www.dh.gov.uk/en/Publicationsandstatistics/Lettersandcirculars/Healthservicecirculars/DH_4004561.
56. Perry C.M., Wilde M.I. Interferon-alpha-2a: a review of its use in chronic hepatitis C. Biodrugs 1998, 10:65-89.
57. Gunson R.N., Shouval D., Roggendorf M., Zaaijer H., Nicholas H., Holzmann H., et al. Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in health care workers (HCWs): guidelines for prevention of transmission of HBV and HCV from HCW to patients. J Clin Virol 2003, 27:213-230.
58. Commissie voor preventie van iatrogene hepatitis B. Landelijke richtlijn Preventie iatrogene Hepatitis B. Bilthoven, The Netherlands: RIVM-Centrum Infectieziektebestrijding; 2007.
59. Differing guidelines toward the infected healthcare worker. Viral Hepat 2005;14:14.
60. Daha T.J., Bilkert-Mooiman M.A., Ballemans C., Frijstein G., Keeman J.N., de Man R.A., et al. Hepatitis B virus infected health care workers in The Netherlands, 2000-2008. Eur J Clin Microbiol Infect Dis 2009, 28:1041-1044.
61. Buster E.H., van der Eijk A.A., de Man R.A., Janssen H.L., Schalm S.W. Prolonged antiviral therapy for hepatitis B virus-infected health care workers: a feasible option to prevent work restriction without jeopardizing patient safety. J Viral Hepat 2007, 14:350-354.
62. Raggam R.B., Rossmann A.M., Salzer H.J., Stauber R.E., Kessler H.H. Health care worker-to-patient transmission of hepatitis C virus in the health care setting: many questions and few answers. J Clin Virol 2009, 45:272-275.
63. Reitsma A.M., Closen M.L., Cunningham M., Lombardo P.A., Minich H.N., Moreno J.D., et al. Infected physicians and invasive procedures: safe practice management. Clin Infect Dis 2005, 40:1665-1672.
64. Henderson DK, Dembry L, Fishman NO, Grady C, Lundstrom T, Palmore TN, et al. SHEA guideline for management of healthcare workers who are infected with hepatitis B virus, hepatitis C virus, and/or human immunodeficiency virus. Infect Control Hosp Epidemiol 2010;31:203-32.
65. Asselah T., Marcellin P. New direct-acting antivirals' combination for the treatment of chronic hepatitis C. Liver Int 2011, 31(Suppl. 1):68-77.
66. Recommendations for preventing transmission of human immunodeficiency virus and hepatitis B virus to patients during exposure-prone invasive procedures. MMWR Recomm Rep 1991;40:1-9.
67. Tuboku-Metzger J., Chiarello L., Sinkowitz-Cochran R.L., Casano-Dickerson A., Cardo D. Public attitudes and opinions toward physicians and dentists infected with bloodborne viruses: results of a national survey. Am J Infect Control 2005, 33:299-303.
68. Lee R. Occupational transmission of bloodborne diseases to healthcare workers in developing countries: meeting the challenges. J Hosp Infect 2009, 72:285-291.
69. Talaat M., Kandeel A., El-Shoubary W., Bodenschatz C., Khairy I., Oun S., et al. Occupational exposure to needlestick injuries and hepatitis B vaccination coverage among health care workers in Egypt. Am J Infect Control 2003, 31:469-474.
70. Tarantola A., Koumare A., Rachline A., Sow P.S., Diallo M.B., Doumbia S., et al. A descriptive, retrospective study of 567 accidental blood exposures in healthcare workers in three West African countries. J Hosp Infect 2005, 60:276-282.
71. Hutin Y.J., Hauri A.M., Armstrong G.L. Use of injections in healthcare settings worldwide, 2000: literature review and regional estimates. BMJ 2003, 327:1075.
72. Talaat M., el-Oun S., Kandeel A., Abu-Rabei W., Bodenschatz C., Lohiniva A.L., et al. Overview of injection practices in two governorates in Egypt. Trop Med Int Health 2003, 8:234-241.