Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 8, 2015, Pages 2413-2418

  Plimptona, Rebecca L ^a   Cuéllarb, Jorge ^b   Lai, Chun Wan J ^a   Aoba, Takuma ^a   Makaju, Aman ^c   Franklin, Sarah ^c   Mathis, Andrew D ^a   Prince, John T ^a   Carrascosa, José L ^b   Valpuesta, José M ^b   Willardson, Barry M ^a  

^a Brigham Young University   (United States)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Chaperonin; Cross linking; Electron cryo microscopy; G protein; Phosducin like protein

Indexed keywords

CHAPERONE; CHAPERONIN CONTAINING TCP1; DIMER; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; PHOSDUCIN LIKE PROTEIN 1; UNCLASSIFIED DRUG; 4-BENZOYLPHENYLALANINE; AMINO ACID; BENZOPHENONE DERIVATIVE; CARRIER PROTEIN; CROSS LINKING REAGENT; G-PROTEIN BETA GAMMA; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; NERVE PROTEIN; PDCL PROTEIN, HUMAN; PHENYLALANINE;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CROSS LINKING; CRYOELECTRON MICROSCOPY; HEK293 CELL LINE; MASS SPECTROMETRY; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STRUCTURE; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; ULTRASTRUCTURE;

AMINO ACIDS; ANIMALS; BENZOPHENONES; CARRIER PROTEINS; CHAPERONIN CONTAINING TCP-1; CROSS-LINKING REAGENTS; CRYOELECTRON MICROSCOPY; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; HUMANS; MASS SPECTROMETRY; MODELS, MOLECULAR; NERVE TISSUE PROTEINS; PHENYLALANINE; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY;

EID: 84923657460     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1419595112     Document Type: Article

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