Novel mode of action of polybia-MPI, a novel antimicrobial peptide, in multi-drug resistant leukemic cells

Cancer Letters

Volumn 278, Issue 1, 2009, Pages 65-72

  Wang, Kai rong ^a,b   Yan, Jie xi ^b   Zhang, Bang zhi ^a,b   Song, Jing jing ^b   Jia, Peng fei ^b   Wang, Rui ^a,b  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b Institute of Biochemistry and Molecular Biology   (China)

Author keywords

Multi drug resistant; Necrosis; Plasma membrane perturbation; Polybia MPI; Selective toxicity

Indexed keywords

AMPHOPHILE; ISOLEUCYLASPARTYLTRYPTOPHYLLYSYLLYSYLLEUCYLLEUCYLASPARTYLALANYLALANYLLYSYLGLUTAMINYLISOLEUCYLLEUCINAMIDE; PHOSPHOLIPID; POLYPEPTIDE ANTIBIOTIC AGENT; PROPIDIUM IODIDE; TRYPAN BLUE; UNCLASSIFIED DRUG;

ALPHA HELIX; ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL MEMBRANE; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG SELECTIVITY; ELECTRICITY; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; MEMBRANE BINDING; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; TARGET CELL; WASP;

ANIMALS; ANNEXIN A5; ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL DIVISION; CELL LINE, TUMOR; CELL MEMBRANE; CELL SURVIVAL; DRUG RESISTANCE, MULTIPLE; FLOW CYTOMETRY; HL-60 CELLS; HUMANS; INSECT PROTEINS; LEUKEMIA L1210; MICE; NECROSIS; PEPTIDES; WASPS;

POLYBIA;

EID: 63649150812     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.12.027     Document Type: Article

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