rBPI21 promotes lipopolysaccharide aggregation and exerts its antimicrobial effects by (hemi)fusion of PG-containing membranes

PLoS ONE

Volumn 4, Issue 12, 2009, Pages

  Domingues, Marco M ^a   Castanho, Miguel A R B ^a   Santos, Nuno C ^a  

^a INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE; LIPOSOME; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLGLYCEROL; POLYPEPTIDE ANTIBIOTIC AGENT; RECOMBINANT BACTERICIDAL PERMEABILITY INCEASING PROTEIN 21; UNCLASSIFIED DRUG; 6 CARBOXYFLUORESCEIN; 6-CARBOXYFLUORESCEIN; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; BACTERICIDAL PERMEABILITY INCREASING PROTEIN; FLUORESCEIN DERIVATIVE; PLASMA PROTEIN;

ARTICLE; BACTERIAL MEMBRANE; BACTERICIDAL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; GRAM NEGATIVE BACTERIUM; INTERNALIZATION; LIGHT SCATTERING; LIPID VESICLE; MEMBRANE FUSION; MEMBRANE PERMEABILITY; MOLECULAR RECOGNITION; NONHUMAN; PHAGOCYTOSIS; ZETA POTENTIAL; BIOLOGICAL MODEL; CHEMISTRY; DRUG EFFECT; LIGHT; METABOLISM; MOLECULAR WEIGHT; RADIATION SCATTERING;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BLOOD PROTEINS; FLUORESCEINS; LIGHT; LIPOPOLYSACCHARIDES; MEMBRANE FUSION; MODELS, BIOLOGICAL; MOLECULAR WEIGHT; PHOSPHATIDYLGLYCEROLS; SCATTERING, RADIATION; UNILAMELLAR LIPOSOMES;

EID: 77949517357     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008385     Document Type: Article

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