Mutant α-synuclein enhances firing frequencies in dopamine substantia nigra neurons by oxidative impairment of A-type potassium channels

Journal of Neuroscience

Volumn 34, Issue 41, 2014, Pages 13586-13599

  Subramaniam, Mahalakshmi ^a   Althof, Daniel ^c   Gispert, Suzana ^b   Schwenk, Jochen ^c   Auburger, Georg ^b   Kulik, Akos ^c   Fakler, Bernd ^c   Roeper, Jochen ^a  

^a Institute for Neurophysiology   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

A type K channel; Dopamine; In vivo; Redox; Substantia nigra; synuclein

Indexed keywords

ALPHA SYNUCLEIN; DOPAMINE; SHAL POTASSIUM CHANNEL; GLUTATHIONE;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CONTROLLED STUDY; DOPAMINE RELEASE; GAIN OF FUNCTION MUTATION; GENE OVEREXPRESSION; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LASER MICROSCOPY; MALE; MESENCEPHALON; MOUSE; MUTANT; NERVE POTENTIAL; NONHUMAN; OXIDATION; PARKINSON DISEASE; PHENOTYPE; POTASSIUM CHANNELOPATHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUBSTANTIA NIGRA; SYNAPTIC TRANSMISSION; TRANSMISSION ELECTRON MICROSCOPY; VENTRAL TEGMENTUM; AGING; ANIMAL; CHANNEL GATING; CYTOLOGY; DOPAMINERGIC NERVE CELL; ELECTROPHYSIOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MUTATION; OXIDATIVE STRESS; PHYSIOLOGY;

AGING; ALPHA-SYNUCLEIN; ANIMALS; DOPAMINERGIC NEURONS; ELECTROPHYSIOLOGICAL PROCESSES; GLUTATHIONE; ION CHANNEL GATING; MALE; MICE; MUTATION; OXIDATIVE STRESS; SHAL POTASSIUM CHANNELS; SUBSTANTIA NIGRA; VENTRAL TEGMENTAL AREA;

EID: 84923426070     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5069-13.2014     Document Type: Article

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