Rescue of an in vitro neuron phenotype identified in niemann-pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the wnt pathway and calcium signaling

Stem Cells Translational Medicine

Volumn 4, Issue 3, 2015, Pages 230-238

  Efthymiou, Anastasia G ^a   Steiner, Joe ^b   Pavan, William J ^c   Wincovitch, Stephen ^c   Larson, Denise M ^c   Porter, Forbes D ^d   Rao, Mahendra S ^e   Malik, Nasir ^a  

^a NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d Eunice Kennedy Shriver National Institute for Child Health and Human Development   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Calcium signaling; Disease modeling; Neural stem cells; Niemann pick disease; Type C1; WNT signaling

Indexed keywords

BETA TUBULIN; CALCIUM; CHOLESTEROL; CURCUMIN; DANTROLENE; MICROTUBULE ASSOCIATED PROTEIN 2; OCTAMER TRANSCRIPTION FACTOR 4; PODOCALYXIN; TRANSCRIPTION FACTOR NANOG; WNT PROTEIN; CARRIER PROTEIN; MEMBRANE PROTEIN; NPC1 PROTEIN, HUMAN;

ARTICLE; CALCIUM SIGNALING; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; FIBROBLAST; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GLIA CELL; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; KARYOTYPING; MTT ASSAY; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NIEMANN PICK DISEASE; PHENOTYPE; UPREGULATION; WNT SIGNALING PATHWAY; CELL LINE; GENETICS; INDUCED PLURIPOTENT STEM CELL; METABOLISM; MUTATION; NERVE CELL; PATHOLOGY;

ANIMALIA; RODENTIA;

CALCIUM SIGNALING; CARRIER PROTEINS; CELL LINE; FIBROBLASTS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MEMBRANE GLYCOPROTEINS; MUTATION; NEURONS; NIEMANN-PICK DISEASE, TYPE C; WNT SIGNALING PATHWAY;

EID: 84923388603     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2014-0127     Document Type: Article

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