Combination of mild hypothermia with neuroprotectants has greater neuroprotective effects during oxygen-glucose deprivation and reoxygenation-mediated neuronal injury

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Gao, Xiao Ya ^a   Huang, Jian Ou ^a,b   Hu, Ya Fang ^a   Gu, Yong ^a   Zhu, Shu Zhen ^a   Huang, Kai Bin ^a   Chen, Jin Yu ^a   Pan, Su Yue ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b Department of Neurology ^*  (China)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CULTURE MEDIUM; DIZOCILPINE MALEATE; GLOBIN; GLUCOSE; KALLIKREIN; NERVE PROTEIN; NEUROGLOBIN; NEUROPROTECTIVE AGENT; OXYGEN; REACTIVE OXYGEN METABOLITE;

ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BRAIN CORTEX; CELL SURVIVAL; CHEMISTRY; COLD; CULTURE MEDIUM; DEFICIENCY; DRUG EFFECTS; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MULTIMODALITY CANCER THERAPY; NERVE CELL; NEWBORN; PATHOLOGY; PRIMARY CELL CULTURE; RAT; REPERFUSION INJURY; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CALCIUM; CELL SURVIVAL; CEREBRAL CORTEX; COLD TEMPERATURE; COMBINED MODALITY THERAPY; CULTURE MEDIA; DIZOCILPINE MALEATE; GLOBINS; GLUCOSE; KALLIKREINS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; OXYGEN; PRIMARY CELL CULTURE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY;

EID: 84923355695     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep07091     Document Type: Article

References (53)

1. Xing, C., Arai, K., Lo, E. H. & Hommel, M. Pathophysiologic cascades in ischemic stroke. Int J Stroke. 7, 378-385 (2012).
2. Eltzschig, H. K. & Eckle, T. Ischemia and reperfusion-from mechanism to translation. Nat Med. 17, 1391-1401 (2011).
3. Zielińska, M., Law, R. O. & Albrecht, J. Excitotoxic mechanism of cell swelling in rat cerebral cortical slices treated acutely with ammonia. Neurochem Int. 43, 299-303 (2003).
4. Cimarosti, H., Kantamneni, S. & Henley, J. M. Ischaemia differentially regulates GABA(B) receptor subunits in organotypic hippocampal slice cultures. Neuropharmacology. 56, 1088-1096 (2009).
5. Ouardouz, M., Malek, S., Coderre, E. & Stys, P. K. Complex interplay between glutamate receptors and intracellular Ca21 stores during ischaemia in rat spinal cord white matter. J Physiol. 577, 191-204 (2006).
6. Fujimura, N., Tanaka, E., Yamamoto, S., Shigemori, M. & Higashi, H. Contribution of ATP-sensitive potassium channels to hypoxic hyperpolarization in rat hippocampal CA1 neurons in vitro. J Neurophysiol. 77, 378-385 (1997).
7. Cyrino, F. Z., Bottino, D. A., Coelho, F. C., Ravel, D. & Bouskela, E. Effects of sulfonylureas on K(ATP) channel-dependent vasodilation. 17, 6-10 (2003).
8. Suzuki, M. et al. Effects of serotonin1A agonists on anoxia-induced impairment of protein synthesis in rat brain slices. Jpn J Pharmacol. 67, 403-405 (1995).
9. Richard, M. J., Saleh, T. M., El Bahh, B. & Zidichouski, J. A. A novel method for inducing focal ischemia in vitro. J Neurosci Methods. 190, 20-27 (2010).
10. Park, H. A. et al. Natural vitamin E alpha-tocotrienol protects against ischemic stroke by induction of multidrug resistance-associated protein 1. Stroke. 42, 2308-2314 (2011).
11. Dvoriantchikova, G.,Grant, J., Santos, A. R.,Hernandez, E. Ivanov, D. Neuronal NAD(P)H oxidases contribute to ROS production and mediate RGC death after ischemia. Invest Ophthalmol Vis Sci. 53, 2823-2830 (2012).
12. Culot, M. et al. Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: an in vitro study. Brain Res. 1294, 144-152 (2009).
13. Kwon, M., Fernández, J. R., Zegarek, G. F., Lo, S. B. & Firestein, B. L. BDNFpromoted increases in proximal dendrites occur via CREB-dependent transcriptional regulation of cypin. J Neurosci. 31, 9735-9745 (2011).
14. Taylor, M. D., Mellert, T. K., Parmentier, J. L. & Eddy, L. J. Pharmacological protection of reoxygenation damage to in vitro brain slice tissue. Brain Res. 347, 268-273 (1985).
15. Bösel, J. et al. Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones. J Neurochem. 92, 1386-1398 (2005).
16. Radley, E., Akram, A., Grubb, B. D. & Gibson, C. L. Investigation of the mechanisms of progesterone protection following oxygen-glucose deprivation in organotypic hippocampal slice cultures. Neurosci Lett. 506, 131-135 (2012).
17. Clerc, P. et al. Magnesium sulfate protects against the bioenergetic consequences of chronic glutamate receptor stimulation. PLoS One. 8, e79982 (2013).
18. Zhang, L. J. et al. Human albumin prevents 6-hydroxydopamine-induced loss of tyrosine hydroxylase in in vitro and in vivo. PLoS One. 7, e41226 (2012).
19. Liu, L. et al. Tissue kallikrein protects cortical neurons against hypoxia/reoxygenation injury via the ERK1/2 pathway. Biochem Biophys Res Commun. 407, 283-287 (2011).
20. Yousuf, S., Atif, F., Kesherwani, V. & Agrawal, S. K. Neuroprotective effects of Tacrolimus (FK-506) and Cyclosporin (CsA) in oxidative injury. Brain Behav. 1, 87-94 (2011).
21. Kraus, R. L. et al. Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical-scavenging activity. J Neurochem. 94, 819-827 (2005).
22. Hurtado, O. et al. Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport. Neurobiol Dis. 18, 336-345 (2005).
23. Liu, J. R. et al. Monosialoganglioside protected ischemic rat hippocampal slices through stabilizing expression of N-methyl-D-aspartate receptor subunit. Acta Pharmacol Sin. 26, 727-732 (2004).
24. Chen, X. et al. Endoplasmic reticulum Ca21 dysregulation and endoplasmic reticulum stress following in vitro neuronal ischemia: role of Na1-K1-Clcotransporter. J Neurochem. 106, 1563-1576 (2008).
25. Raychaudhuri, S., Skommer, J., Henty, K., Birch, N. & Brittain, T. Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death. Apoptosis. 15, 401-411 (2010).
26. Pozdnyakova, N., Yatsenko, L., Parkhomenko, N. & Himmelreich, N. Perinatal hypoxia induces a long-lasting increase in unstimulated gaba release in rat brain cortex and hippocampus. The protective effect of pyruvate. Neurochem Int. 58, 14-21 (2011).
27. Xu, S. Y. & Pan, S. Y. The failure of animal models of neuroprotection in acute ischemic stroke to translate to clinical efficacy. Med Sci Monit Basic Res. 28, 37-45 (2013).
28. Kaur, H., Prakash, A. & Medhi, B. Drug Therapy in Stroke: From Preclinical to Clinical Studies. Pharmacology. 92, 324-334 (2013).
29. Zhao, J. K. et al. Effect of focal mild hypothermia on expression of MMP-9, TIMP-1, Tau-1 and b-APP in rats with cerebral ischaemia/reperfusion injury. Brain Inj. 27, 1190-1198 (2013).
30. van der Worp, H. B., Sena, E. S., Donnan, G. A., Howells, D. W. Macleod,M. R. Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis. Brain. 130, 3063-3074 (2007).
31. Nakai, A. et al. Influence of mild hypothermia on delayed mitochondrial dysfunction after transient intrauterine ischemia in the immature rat brain. Brain Res Dev Brain Res. 128, 1-7 (2001).
32. Jena, A. B., Romley, J. A., Newton-Cheh, C. & Noseworthy, P. Therapeutic hypothermia for cardiac arrest: real-world utilization trends and hospital mortality. J Hosp Med. 7, 684-689 (2012).
33. Gancia, P. & Pomero, G. Therapeutic hypothermia in the prevention of hypoxicischaemic encephalopathy: new categories to be enrolled. JMatern Fetal Neonatal Med. 25, 94-96 (2012).
34. Yenari, M. A. & Hemmen, T. M. Therapeutic hypothermia for brain ischemia: where have we come and where do we go Stroke. 41, 72-74 (2010).
35. Lyden, P. D. et al. Intravascular Cooling in the Treatment of Stroke (ICTuS): early clinical experience. J Stroke Cerebrovasc Dis. 14, 107-114 (2005).
36. Piironen, K. et al. Mild hypothermia after intravenous thrombolysis in patients with acute stroke: a randomized controlled trial. Stroke. 45, 486-491 (2014).
37. Berger, C. et al. Hypothermia and brain-derived neurotrophic factor reduce glutamate synergistically in acute stroke. Experimental Neurology. 185, 305-312 (2004).
38. Hoffmeister, H. M. et al. Fibrin specificity and procoagulant effect related to the kallikrein-contact phase system and to plasmin generation with double-bolus reteplase and front-loaded alteplase thrombolysis in acute myocardial infarction. Am J Cardiol. 86, 263-268 (2000).
39. Emanueli, C. & Madeddu, P. Angiogenesis therapy with human tissue kallikrein for the treatment of ischemic diseases. Arch Mal Coeur Vaiss. 97, 679-687 (2004).
40. Lyden, P. D. & Hedges, B. Protective effect of synaptic inhibition during cerebral ischemia in rats and rabbits. Stroke. 23, 1463-1469 (1992).
41. Kato, T. Memantine: a therapeutic drug for Alzheimer's disease and the comparison with MK-801. Nihon Yakurigaku Zasshi. 124, 145-151 (2004).
42. Alkan, T., Kahveci, N., Buyukuysal, L., Korfali, E. & Ozluk, K. Neuroprotective effects of MK 801 and hypothermia used alone and in combination in hypoxicischemic brain injury in neonatal rats. Arch Physiol Biochem. 109, 135-144 (2001).
43. Celik, S. E., Oztürk, H. & Tolunay, S. Therapeutic effect of hypothermia and dizocilpine maleate on traumatic brain injury in neonatal rats. JNeurotrauma. 23, 1355-1365 (2006).
44. Sun, Y. et al. Neuroglobin protects the brain from experimental stroke in vivo. Proc Natl Acad Sci USA. 100, 3497-3500 (2003).
45. Raida, Z., Hundahl, C. A., Nyengaard, J. R. & Hay-Schmidt, A. Neuroglobin over expressing mice: expression pattern and effect on brain ischemic infarct size. PLoS One. 8, e76565 (2013).
46. Song, W. et al. Intra-carotid cold magnesium sulfate infusion induces selective cerebral hypothermia and neuroprotection in rats with transient middle cerebral artery occlusion. Neurol Sci. 34, 479-486 (2013).
47. Jeong, C. H. et al.Mesenchymal stem cells expressing brain-derived neurotrophic factor enhance endogenous neurogenesis in an ischemic stroke model. Biomed Res Int. 2014, 129145 (2014).
48. Chen, J. et al. Enhanced neuroprotection by local intra-arterial infusion of human albumin solution and local hypothermia. Stroke. 44, 260-262 (2013).
49. Kimberly, W. T. et al. Glyburide is associated with attenuated vasogenic edema in stroke patients. Neurocrit Care. 20, 193-201 (2014).
50. Sheth, K. N. Novel approaches to the primary prevention of edema after ischemia. Stroke. 44, S136 (2013).
51. Xu, S. Y., Wu, Y. M., Ji, Z., Gao, X. Y. & Pan, S. Y. A Modified Technique for Culturing Primary Fetal Rat Cortical Neurons. Journal of Biomedicine and Biotechnology. 2012, 1-7 (2012).
52. Ingrassia, R. et al. 1B/(-)IRE DMT1 expression during brain ischemia contributes to cell death mediated by NF-kappaB/RelA acetylation at Lys310. PLoS One. 7, e38019 (2012).
53. Dessi, F. & Ben-Ari, Y., Charriaut-Marlangue, C. Riluzole prevents anoxic injury in cultured cerebellar granule neurons. Eur J Pharmacol. 250, 325-328 (1993).