Natural vitamin e α-tocotrienol protects against ischemic stroke by induction of multidrug resistance-associated protein 1

Stroke

Volumn 42, Issue 8, 2011, Pages 2308-2314

  Park, Han A ^a   Kubicki, Natalia ^a   Gnyawali, Surya ^a   Chan, Yuk Cheung ^a   Roy, Sashwati ^a   Khanna, Savita ^a   Sen, Chandan K ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

antioxidant; glutathione; microRNA; vitamin E

Indexed keywords

ALPHA TOCOTRIENOL; CAROTECH; GLUTAMIC ACID; GLUTATHIONE DISULFIDE; MICRORNA; MULTIDRUG RESISTANCE PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN DAMAGE; BRAIN ISCHEMIA; BRAIN TISSUE; CONTROLLED STUDY; DOWN REGULATION; FETUS; GENE SILENCING; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN TARGETING; RAT; VITAMIN SUPPLEMENTATION;

ANIMALS; ANTIOXIDANTS; BRAIN ISCHEMIA; CELL DEATH; CEREBRAL CORTEX; MALE; MICE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; STROKE; VITAMIN E;

EID: 79961209314     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.110.608547     Document Type: Article

References (22)

1. Khanna S, Roy S, Slivka A, Craft TK, Chaki S, Rink C, et al. Neuroprotective properties of the natural vitamin E alpha-tocotrienol. Stroke. 2005;3610:2258-2264. (Pubitemid 41429256)
2. Sen CK, Khanna S, Roy S, Packer L. Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60 (c-Src) kinase activation and death of HT4 neuronal cells. J Biol Chem. 2000;27517: 13049-13055. (Pubitemid 30241466)
3. Khanna S, Roy S, Parinandi NL, Maurer M, Sen CK. Characterization of the potent neuroprotective properties of the natural vitamin E alphatocotrienol. J Neurochem. 2006;985:1474-1486. (Pubitemid 44200439)
4. Park HA, Khanna S, Rink C, Gnyawali S, Roy S, Sen CK. Glutathione disulfide induces neural cell death via a 12-lipoxygenase pathway. Cell Death Differ. 2009;168:1167-1179.
5. Minich T, Riemer J, Schulz JB, Wielinga P, Wijnholds J, Dringen R. The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes. J Neurochem. 2006;972:373-384.
6. Sen CK. Cellular thiols and redox-regulated signal transduction. Curr Top Cell Regul. 2000;36:1-30.
7. Miller ER, III, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;1421:37-46.
8. Schurks M, Glynn RJ, Rist PM, Tzourio C, Kurth T. Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials. BMJ. 2010;341:c5702.
9. Khanna S, Roy S, Park HA, Sen CK. Regulation of c-Src activity in glutamate-induced neurodegeneration. J Biol Chem. 2007;28232: 23482-23490. (Pubitemid 47311965)
10. Schanne FA, Kane AB, Young EE, Farber JL. Calcium dependence of toxic cell death: a final common pathway. Science. 1979;2064419:700-702. (Pubitemid 10203221)
11. Leslie SW, Brown LM, Trent RD, Lee YH, Morris JL, Jones TW, et al. Stimulation of N-methyl-D-aspartate receptor-mediated calcium entry into dissociated neurons by reduced and oxidized glutathione. Mol Pharmacol. 1992;412:308-314.
12. Hirrlinger J, Konig J, Keppler D, Lindenau J, Schulz JB, Dringen R. The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress. J Neurochem. 2001; 762:627-636. (Pubitemid 32097039)
13. Adibhatla RM, Hatcher JF, Dempsey RJ. Effects of citicoline on phospholipid and glutathione levels in transient cerebral ischemia. Stroke. 2001;3210:2376-2381. (Pubitemid 32954811)
14. Kim J, Kim KY, Jang HS, Yoshida T, Tsuchiya K, Nitta K, et al. Role of cytosolic NADP-dependent isocitrate dehydrogenase in ischemiareperfusion injury in mouse kidney. Am J Physiol Renal Physiol. 2009; 2963:F622-633.
15. Sisodiya SM, Lin WR, Harding BN, Squier MV, Thom M. Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy. Brain. 2002;125Pt 1:22-31. (Pubitemid 34084034)
16. Sultana R, Butterfield DA. Oxidatively modified GST and MRP1 in Alzheimer's disease brain: implications for accumulation of reactive lipid peroxidation products. Neurochem Res. 2004;2912:2215-2220. (Pubitemid 40036893)
17. Rink C, Khanna S. MicroRNA in Ischemic Stroke Etiology and Pathology. Physiol Genomics. 2010.
18. Yin KJ, Deng Z, Huang H, Hamblin M, Xie C, Zhang J, et al. miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia. Neurobiol Dis. 2010;381:17-26.
19. Lee ST, Chu K, Jung KH, Yoon HJ, Jeon D, Kang KM, et al. MicroRNAs induced during ischemic preconditioning. Stroke. 2010;418:1646-1651.
20. Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, et al. Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res. 2009;1047:879-886.
21. Khanna S, Roy S, Maurer M, Ratan RR, Sen CK. Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: prolyl hydroxylases tune the biological normoxic set point. Free Radic Biol Med. 2006;4012:2147-2154. (Pubitemid 43903101)
22. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, et al. Executive summary: heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation. 2010; 1217:948-954.