A sensitive liquid chromatography-tandem mass spectrometry method for pharmacokinetics and tissue distribution of nuciferine in rats

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 961, Issue , 2014, Pages 20-28

  Gu, Shengying ^a   Zhu, Guanhua ^a   Wang, Yuzhu ^a   Li, Qin ^a   Wu, Xin ^a   Zhang, Jigang ^a   Liu, Gaolin ^a   Li, Xiaoyu ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

LC MS MS; Nuciferine; Pharmacokinetics; Tissue distribution

Indexed keywords

BIOCHEMISTRY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUTRITION; PHARMACOKINETICS; RATS; TISSUE;

INTRAVENOUS ADMINISTRATION; LC-MS/MS; LIQUID CHROMATOGRAPHY WITH TANDEM MASS SPECTROMETRIES; NUCIFERINE; PHARMACOKINETIC PARAMETERS; SENSITIVE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; SYSTEMIC CIRCULATION; TISSUE DISTRIBUTIONS;

TISSUE ENGINEERING;

ANTIOBESITY AGENT; NUCIFERINE; UNCLASSIFIED DRUG; APORPHINE DERIVATIVE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG TISSUE LEVEL; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY; LIMIT OF QUANTITATION; LIVER; LUNG; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHARMACOKINETICS; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; SPLEEN; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BIOAVAILABILITY; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; ORAL DRUG ADMINISTRATION; PROCEDURES; REPRODUCIBILITY; TISSUE DISTRIBUTION;

ADMINISTRATION, INTRAVENOUS; ADMINISTRATION, ORAL; ANIMALS; APORPHINES; BIOLOGICAL AVAILABILITY; RATS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

EID: 84901191618     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.04.038     Document Type: Article

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