Identification of ginkgolide B metabolites in urine and rat liver cytochrome P450 enzymes responsible for their formation in vitro

Acta Pharmacologica Sinica

Volumn 29, Issue 3, 2008, Pages 376-384

  Wang, Dian Lei ^a,b   Liang, Yan ^a   Chen, Wei Dong ^a   Xie, Lin ^a   Wang, Guang Ji ^a   Liu, Xiao Dong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b ANHUI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Cytochrome P450 enzymes; Ginkgolide B; Liver microsomes; Metabolism; Rat; Urine

Indexed keywords

ALPHA NAPHTHOFLAVONE; CYTOCHROME P450; CYTOCHROME P450 INHIBITOR; DIETHYLDITHIOCARBAMIC ACID; DRUG METABOLITE; GINKGOLIDE B; HYDROXYL GROUP; KETOCONAZOLE; LIVER ENZYME; QUINIDINE; SULFAPHENAZOLE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG METABOLISM; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; QUADRUPOLE MASS SPECTROMETRY; RAT; URINE;

EID: 39849090610     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2008.00758.x     Document Type: Article

References (13)

1. 1 Braquet P. Proofs of involvement of PAF‐acether in various immune disorders using BN 52021 (ginkgolide B): a powerful PAF‐acether antagonist isolated from Ginkgo biloba L. Adv Prostaglandin Thromboxane Leukot Res 1986 ; 16: 179–98.
2. 2 Prehn JH, Krieglstein J. Platelet‐activating factor antagonists reduce excitotoxic damage in cultured neurons from embryonic chick telencephalon and protect the rat hippocampus and neocortex from ischemic injury in vivo. J Neurosci Res 1993 ; 34: 179–88.
3. 3 Liu XH, Eun BL, Silverstein FS, Barks JD. The platelet‐activating factor antagonist BN 52021 attenuates hypoxic‐ischemic brain injury in the immature rat. Pediatr Res 1996 ; 40: 797–803.
4. 4 Koch E. Inhibition of platelet activating factor (PAF)‐induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. Phytomedicine 2005 ; 12: 10–6.
5. 5 Beck JC, Goodner CJ, Wilson C, Wilson D, Glidden D, Baskin DG, et al. Effects of ginkgolide B, a platelet‐activating factor inhibitor on insulitis in the spontaneously diabetic BB rat. Autoimmunity 1991 ; 9: 225–35.
6. 6 Oberpichler H, Sauer D, Rossberg C, Mennel HD, Krieglstein J. PAF antagonist ginkgolide B reduces postischemic neuronal damage in rat brain hippocampus. J Cereb Blood Flow Metab 1990 ; 10: 133–5.
7. 7 Bate C, Salmona M, Williams A. Ginkgolide B inhibits the neurotoxicity of prions or amyloid‐β 1‐42. J Neuroinfammation 2004 ; 1: 4–11.
8. 8 Chen WD, Liang Y, Xie L, Lu T, Liu XD, Wang GJ. Pharmacokintics of the ginkgo B following intravenous administration of ginkgo B emulsion in rats. Biol Pharm Bull 2007 ; 30: 1–5.
9. 9 Liu XQ, Zhao Y, Li D, Qian ZY, Wang GJ. Metabolism and metabolic inhibition of clinipine in human liver microsomes. Acta Pharmacol Sin 2003 ; 24: 263–8.
10. 10 Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin‐phenol reagent. J Biol Chem 1951 ; 193: 265–75.
11. 11 Liu YT, Hao K, Liu XQ, Wang GJ. Metabolism and metabolic inhibition of gambogic acid in rat liver microsomes. Acta Pharmacol Sin 2006 ; 27: 1253–8.
12. 12 Van Beek TA. Ginkgolides and bilobalide: Their physical, chromatographic and spectroscopic properties. Bioorg Med Chem 2005 ; 13: 5001–12.
13. 13 Suehiro M, Simpson NR, Underwood MD, Castrillon J, Nakanishi K, Van Heertum R. In vivo biodistribution of ginkgolide B, a constituent of Ginkgo biloba, visualized by MicroPET. Planta Med 2005 ; 71: 622–7.