A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase

Nature Communications

Volumn 5, Issue , 2014, Pages

  Giganti, David ^a   Bouillon, Anthony ^b   Tawk, Lina ^a   Robert, Fabienne ^b   Martinez, Mariano ^b   Crublet, Elodie ^c   Weber, Patrick ^d   Girard Blanc, Christine ^e   Petres, Stéphane ^a   Haouz, Ahmed ^a   Hernandez, Jean François ^a   Mercereau Puijalon, Odile ^b   Alzari, Pedro M ^a   Barale, Jean Christophe ^a  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

^c UNIV MONTPELLIER   (France)

^d CNRS URA 2581 ^*  (United States)

^e INSTITUT DE BIOLOGIE STRUCTURALE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE; SUBTILASE; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; PROTOZOAL PROTEIN; SUBTILISIN;

BACTERIUM; CATALYST; CRYSTAL STRUCTURE; DRUG; ENZYME ACTIVITY; MALARIA; PARASITE INFESTATION;

ARTICLE; CRYSTAL STRUCTURE; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM VIVAX; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; AMINO ACID SEQUENCE; CRYSTALLOGRAPHY; HUMAN; MALARIA, VIVAX; METABOLISM; MOLECULAR GENETICS; MOLECULARLY TARGETED THERAPY; PROTEIN TERTIARY STRUCTURE;

BACTERIA (MICROORGANISMS); PLASMODIUM BERGHEI; PLASMODIUM VIVAX;

AMINO ACID SEQUENCE; ANTIMALARIALS; CRYSTALLOGRAPHY; HUMANS; MALARIA, VIVAX; MOLECULAR SEQUENCE DATA; MOLECULAR TARGETED THERAPY; PLASMODIUM BERGHEI; PLASMODIUM VIVAX; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS; SUBTILISINS;

EID: 84923344755     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5833     Document Type: Article

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