Microneme protein 5 regulates the activity of Toxoplasma subtilisin 1 by mimicking a subtilisin prodomain

Journal of Biological Chemistry

Volumn 287, Issue 43, 2012, Pages 36029-36040

  Saouros, Savvas ^a   Dou, Zhicheng ^b   Henry, Maud ^a   Marchant, Jan ^a   Carruthers, Vern B ^b   Matthews, Stephen ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; C-TERMINAL PEPTIDES; HOST CELLS; INTRACELLULAR PARASITES; MULTISTEP PROCESS; PARASITE; PHYSICAL INTERACTIONS; POTENT INHIBITOR; SMALL MOLECULE INHIBITOR; SUBTILISIN; THREE-DIMENSIONAL STRUCTURE; TOXOPLASMA GONDII;

CELL MEMBRANES;

PROTEINS;

ENZYME INHIBITOR; MICRONEME PROTEIN 5; MICROORGANISM PROTEIN; N [N (N ACETYL LEUCYL)LEUCYL]NORLEUCINE; SUBTILISIN; SUBTILISIN 1; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; ENZYME STRUCTURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; TOXOPLASMA GONDII;

CELL ADHESION MOLECULES; MULTIPROTEIN COMPLEXES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, QUATERNARY; PROTOZOAN PROTEINS; SUBTILISIN; TOXOPLASMA;

EID: 84867813772     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.389825     Document Type: Article

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