3,3'-Diindolylmethane Inhibits Lipopolysaccharide-Induced Microglial Hyperactivation and Attenuates Brain Inflammation

Toxicological Sciences

Volumn 137, Issue 1, 2014, Pages 158-167

  Kim, Hyo Won ^a   Kim, Jiyoung ^a,b,c   Kim, Jaekyoon ^a   Lee, Siyoung ^a   Choi, Bo Ryoung ^d   Han, Jung Soo ^d   Lee, Ki Won ^a,b,c,e   Lee, Hyong Joo ^a,b,c  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University   (South Korea)

^d Konkuk University   (South Korea)

^e Seoul National University   (South Korea)

Author keywords

3,3' diindolylmethane; Brain inflammation; Cruciferous vegetables; Indole 3 carbinol; Microglia; NF B

Indexed keywords

3 INDOLEMETHANOL; 3,3' DIINDOLYLMETHANE; CYCLOOXYGENASE 2; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; 3,3'-DIINDOLYLMETHANE; ACTIN BINDING PROTEIN; AIF1 PROTEIN, MOUSE; ANTIINFLAMMATORY AGENT; CALCIUM BINDING PROTEIN; CULTURE MEDIUM; DIFFERENTIATION ANTIGEN; INDOLE DERIVATIVE; INDOLE-3-CARBINOL; LIPOPOLYSACCHARIDE; MONOCYTE-MACROPHAGE DIFFERENTIATION ANTIGEN; NOS2 PROTEIN, MOUSE; PTGS2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN CELL; CONTROLLED STUDY; DRUG DNA BINDING; DRUG EFFICACY; EMBRYO; ENCEPHALITIS; EXPERIMENTAL DISEASE; HIPPOCAMPUS; IN VIVO STUDY; LIPOPOLYSACCHARIDE INDUCED MICROGLIAL HYPERACTIVATION; MALE; MICROGLIA; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL DEATH; CELL LINE; CHEMICALLY INDUCED; COMPARATIVE STUDY; CULTURE MEDIUM; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PATHOLOGY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIGENS, DIFFERENTIATION; CALCIUM-BINDING PROTEINS; CELL DEATH; CELL LINE; CULTURE MEDIA, CONDITIONED; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENCEPHALITIS; HIPPOCAMPUS; INDOLES; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; MICROFILAMENT PROTEINS; MICROGLIA; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84891298600     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft240     Document Type: Article

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