Lifespan Is Prolonged in Autoimmune-Prone (NZB/NZW) F1 Mice Fed a Diet Supplemented with Indole-3-Carbinol

Journal of Nutrition

Volumn 133, Issue 11, 2003, Pages 3610-3613

  Auborn, Karen J ^a,b   Qi, Mei ^a   Yan, Xiao J ^a   Teichberg, Saul ^a,c   Chen, DaZhi ^a   Madaio, Michael P ^d   Chiorazzi, Nicholas ^a,c  

^a N Shore Long Isl Jewish Res Inst ^*  (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c NORTH SHORE UNIVERSITY HOSPITAL   (United States)

^d HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Anti DNA antibodies; Autoimmunity; Glomerulonephritis; Indole 3 carbinol; Systemic lupus erythematosus

Indexed keywords

16ALPHA HYDROXYESTRONE; 2 HYDROXYESTRONE; 3 INDOLEMETHANOL; DOUBLE STRANDED DNA; IMMUNOGLOBULIN G;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; EPITHELIUM CELL; FEMALE; KIDNEY DISEASE; LIFESPAN; MOUSE; MOUSE STRAIN; NONHUMAN; PROTEINURIA; SYSTEMIC LUPUS ERYTHEMATOSUS; VEGETABLE;

ANIMALIA; MURINAE;

EID: 0242577007     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/133.11.3610     Document Type: Article

References (30)

1. Cervera, R. (2001) The epidemiology and significance of autoimmune diseases in health care. Scand. J. Clin. Lab. Investig. Suppl. 235: 27-30.
2. Davidson, A. & Diamond, B. (2001) Autoimmune diseases. N. Engl. J. Med. 345: 340-350.
3. Wu, W. M., Chiang, B. L., Chang, S. C. & Lin, B. F. (2000) Late feeding of dietary fish oil alleviates disease severity and affects macrophage function in autoimmune NZB/W F1 mice. J. Microbiol. Immunol. Infect. 33: 79-86.
4. Fernandes, G., Friend, P., Yunis, E. J. & Good, R. A. (1978) Influence of dietary restriction on immunologic function and renal disease in (NZB × NZW) F1 mice. Proc. Natl. Acad. Sci. U.S.A. 75: 1500-1504.
5. Kehn, P. & Fernades, G. (2001) The importance of omega-3-fatty acids in the attenuation of immune-mediated diseases. J. Clin. Immunol. 21: 99-101.
6. Jolly, C. A., Muthukumar, A., Avula, C. P., Troyer, D. & Femades, G. (2001) Life span is prolonged in food-restricted autoimmune-prone (NZB × NZW)F(1) mice fed a diet enriched with (n-3) fatty acids. J. Nutr. 131: 2753-2760.
7. Leiba, A., Amital, H., Gershwin, M. E. & Shoenfeld, Y. (2001) Diet and lupus. Lupus 10: 246-248.
8. McCarty, M. F. (2001) Upregulation of lymphocyte apoptosis as a strategy for preventing and treating autoimmune disorders: a role for whole-food vegan diets, fish oil and dopamine agonists. Med. Hypotheses 57: 258-75.
9. Whitacre, C. C., Reingold, S. C. & O'Looney, P. A. (1999) A gender gap in autoimmunity. Science (Washington, D.C.) 283: 1277-1278.
10. Lahita, R. G., Bradlow, H. L., Kunkel, H. G. & Fishman, J. (1979) Alterations of estrogen metabolism in systemic lupus erythematosus. Arthritis Rheum. 22: 1195-1198.
11. Theofilopoulos, A. N. & Dixon, F. J. (1985) Murine models of systemic lupus erythematosus. Adv. Immunol. 37: 269-390.
12. Bynoe, M. S., Grimaldi, C. M. & Diamond, B. (2000) Estrogen upregulates Bcl-2 and blocks tolerance induction of naive B cells. Proc. Natl. Acad. Sci. U.S.A. 97: 2703-2708.
13. Michnovicz, J. J., Adlercreutz, H. & Bradlow, H. L. (1997) Changes in levels of udnary estrogen metabolites after oral indole-3-carbinol treatment in humans. J. Natl. Cancer Inst. 89: 718-723.
14. Meng, Q., Yuan, F., Goldberg, I. D., Rosen, E. M., Auborn, K. & Fan, S. (2000) Indole-3-carbinol is a negative regulator of estrogen receptor-α signaling in human tumor cells. J. Nutr. 130: 2927-2931.
15. Chen, I., Hsieh, T., Thomas, T. & Safe, S. (2001) Identification of estrogen-induced genes downregulated by AhR agonists in MCF-7 breast cancer cells using suppression subtractive hybridization. Gene 262: 207-214.
16. Scones, K., Heaney, R. K. & Fenwick, G. R. (1984) An estimate of the mean daily intake of glucosinolates from cruciferous vegetables in the UK. J. Sci. Food Agric. 35: 712-720.
17. American Institute of Nutrition (1977) Report of the American Institute of Nutrition ad hoc committee for nutritional studies. J. Nutr. 107; 1340-1345.
18. Kaplan, S., Hyman, K., Brooks, R., Wakai, M., Hashimoto, S., Furie, R. & Chiorazzi, N. (1993) Monoclonal IgM, IgG, and IgA human rheumatoid factors produced by synovial tissue-dedved, EBV-transformed B cell lines. Clin. Immunol. Immunopathol. 1: 18-25.
19. Auborn, K., Abramson, A., Bradlow, H. L., Sepkovic, D. & Mullooly, V. (1998) Estrogen metabolism and laryngeal papillomatosis: a pilot study on dietary prevention. Anticancer Res. 18: 4569-4574.
20. Chan, O., Madaio, M. P. & Shlomchik, M. J. (1997) The roles of B cells in MRL/lpr murine lupus. Ann. N.Y. Acad. Sci. 815: 75-87.
21. Wu, W. M., Lin, B. F., Su, Y. C., Suen, J. L. & Chiang, B. L. (2000) Tamoxifen decreases renal inflammation and alleviates disease severity in autoimmune NZB/W F1 mice. Scand. J. Immunol. 52: 393-400.
22. Wu, W. M., Suen, J. L., Lin, B. F. & Chiang, B. L. (2000) Tamoxifen alleviates disease severity and decreases double negative T cells in autoimmune MRL-lpr/lpr mice. Immunology 100: 110-118.
23. Swaneck, G. E. & Fishman, J. (1988) Covalent binding of the endogenous estrogen 16 alpha-hydroxyestrone to estradiol receptor in human breast cancer cells: characterization and intranuclear localization. Proc. Natl. Acad. Sci. U.S.A. 85: 7831-7835.
24. Lustig, R. H., Mobbs, C. V., Pfaff, D. W. & Fishman, J. Temporal actions of 16 alpha-hydroxyestrone in the rat: comparisons of lordosis dynamics with other estrogen metabolites and between sexes. J. Steroid Biochem. 33: 417-421.
25. Schneider, J., Huh, M. M., Bradlow, H. L. & Fishman, J. (1984) Antiestrogen action of 2-hydroxyestrone on MCF-7 human breast cancer cells. J. Biol. Chem. 25: 4840-4845.
26. Cover, C. M., Hsieh, S. J., Tran, S. H., Hallden, G., Kim, G. S., Bjeldanes, L. F. & Firestone, G. L. (1998) Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling. J. Biol. Chem. 273: 3838-3847.
27. Chen, D-Z., Qi, M., Auborn, K. J. & Carter, T. H. (2002) Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium. J. Nutr. 131: 3394-3302.
28. McAlindon, T. E., Gulin, J., Chen, T., Klug, T. Lahita, R. & Nuite, M. (2001) Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity. Lupus 10: 779-783.
29. Rosen, C. A., Woodson, G. E., Thompson, J. W., Hengesteg, A. P. & Bradlow, H. L. (1998) Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol. Head Neck Surg. 118: 810-815.
30. Bell, M. C., Crowley-Nowick, P., Bradlow, H. L., Sepkovic, D. W., Schmidt-Grimminger, D., Howell, P., Mayeaux, E. J., Tucker, A., Turbat-Hferrera, E. A. & Mathis, J. M. (2000) Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol. Oncol. 78: 123-129.