Conformational stability and catalytic activity of PTEN variants linked to cancers and autism spectrum disorders

Biochemistry

Volumn 54, Issue 7, 2015, Pages 1576-1582

  Johnston, Sean B ^a   Raines, Ronald T ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; ENZYMES; MAMMALS; MOBILE SECURITY; PHOSPHOLIPIDS;

AUTISM SPECTRUM DISORDERS; CELLULAR METABOLISM; CONFORMATIONAL STABILITIES; DEPHOSPHORYLATIONS; MEMBRANE COMPONENTS; PHOSPHOINOSITIDES; PHYSIOLOGICAL CONDITION; WILD-TYPE ENZYMES;

CATALYST ACTIVITY;

CALCIUM ION; GLYCINE; PHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SERINE; THREONINE; TYROSINE; PTEN PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; AUTISM; BREAST CANCER; CATALYSIS; CELL METABOLISM; CHEMICAL ANALYSIS; CIRCULAR DICHROISM; CODON; COWDEN SYNDROME; DIFFERENTIAL SCANNING FLUORIMETRY; FLUOROMETRY; HEATING; HUMAN; HUMAN CELL; LIGAND BINDING; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR CROWDING; NONHUMAN; NUCLEOPHILICITY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN STABILITY; PROTEIN UNFOLDING; SOCIAL INTERACTION; SPEECH DELAY; THERMAL DENATURATION; THERMOSTABILITY; ULTRAVIOLET SPECTROSCOPY; WILD TYPE; CHEMICAL STRUCTURE; CHEMISTRY; GENETIC VARIABILITY; GENETICS; METABOLISM; NEOPLASM;

MAMMALIA;

AUTISTIC DISORDER; GENETIC VARIATION; HUMANS; MODELS, MOLECULAR; NEOPLASMS; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN UNFOLDING; PTEN PHOSPHOHYDROLASE;

EID: 84923334626     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b00028     Document Type: Article

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