Neuroanatomy of Obsessive Compulsive and Related Disorders

The Oxford Handbook of Obsessive Compulsive and Spectrum Disorders

Volumn , Issue , 2012, Pages

  Mataix Cols, David ^a   Van Den Heuvel, Odile A ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Anxiety disorders; Body dysmorphic disorder; Brain; Hoarding; Neuroanatomy; Neuroimaging; OCD; Symptom dimensions; Tourette's syndrome; Trichotillomania

Indexed keywords

EID: 84923275391     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1093/oxfordhb/9780195376210.013.0027     Document Type: Chapter

References (130)

1. Abramowitz, J. S., Wheaton, M. G., & Storch, E. A. (2008). The status of hoarding as a symptom of obsessivecompulsive disorder. Behaviour Research and Therapy, 46, 1026-1033.
2. Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience, 9, 357-381.
3. Amaral, D. G. & Price, J. L. (1984). Amygdalo-cortical projections in the monkey (Macaca fascicularis). Journal of Comparative Neurology, 230, 465-496.
4. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed. Text Revision). Washington, DC: Author.
5. An, S. K., Mataix-Cols, D., Lawrence, N. S., Wooderson, S., Giampietro, V., Speckens, A. et al. (2008). To discard or not to discard: the neural basis of hoarding symptoms in obsessive-compulsive disorder. Molecular Psychiatry, 14, 318-331.
6. Anderson, S.W., Damasio, H., Damasio, A.R. (2005). A neural basis for collecting behaviour in humans. Brain, 128, 201-212.
7. Aouizerate, B., Guehl, D., Cuny, E., Rougier, A., Bioulac, B., Tignol, J. et al. (2004). Pathophysiology of obsessivecompulsive disorder: a necessary link between phenomenology, neuropsychology, imagery and physiology. Progress in Neurobiology, 72, 195-221.
8. Armony, J. L., Corbo, V., Clement, M. H., & Brunet, A. (2005). Amygdala response in patients with acute PTSD to masked and unmasked emotional facial expressions. American Journal of Psychiatry, 162, 1961-1963.
9. Ashburner, J. & Friston, K. J. (2001). Why voxel-based morphometry should be used. Neuroimage, 14, 1238-1243.
10. Ashburner, J. & Friston, K. J. (2000). Voxel-based morphometry-the methods. Neuroimage, 11, 805-821.
11. Barbas, H. (2000). Connections underlying the synthesis of cognition, memory, and emotion in primate prefrontal cortices. Brain Research Bulletin, 52, 319-330.
12. Baym, C. L., Corbett, B. A., Wright, S.B., Bunge, S. A. (2008). Neural correlates of tic severity and cognitive control in children with Tourette syndrome. Brain, 131, 165-179.
13. Bechara, A., Tranel, D., & Damasio, H. (2000). Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions. Brain, 123(11), 2189-2202.
14. Birbaumer, N., Grodd, W., Diedrich, O., Klose, U., Erb, M., Lotze, M. et al. (1998). fMRI reveals amygdala activation to human faces in social phobics. Neuroreport, 9, 1223-1226.
15. Blair, K., Shaywitz, J., Smith, B. W., Rhodes, R., Geraci, M., Jones, M. et al. (2008). Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders. American Journal of Psychiatry, 165, 1193-1202.
16. Bloch, M. H., Landeros-Weisenberger, A., Rosario, M. C., Pittenger, C., & Leckman, J. F. (2008). Meta-analysis of the symptom structure of obsessive-compulsive disorder. American Journal of Psychiatry, 165, 1532-1542.
17. Bloch, M. H., Leckman, J. F., Zhu, H., & Peterson, B. S. (2005). Caudate volumes in childhood predict symptom severity in adults with Tourette syndrome. Neurology, 65, 1253-1258.
18. Breiter, H. C., Rauch, S. L., Kwong, K. K., Baker, J. R., Weisskoff, R. M., Kennedy, D. N. et al. (1996). Functional magnetic resonance imaging of symptom provocation in obsessive-compulsive disorder. Archives of General Psychiatry, 53, 595-606.
19. Brown, H. D., Kosslyn, S. M., Delamater, B., Fama, J., & Barsky, A. J. (1999). Perceptual and memory biases for health-related information in hypochondriacal individuals. Journal of Psychosomatic Research, 47, 67-78.
20. Bryant, R. A., Felmingham, K., Whitford, T. J., Kemp, A., Hughes, G., Peduto, A. et al. (2008). Rostral anterior cingulate volume predicts treatment response to cognitive-behavioural therapy for posttraumatic stress disorder. Journal of Psychiatry & Neuroscience, 33, 142-146.
21. Cannistraro, P. A., Wright, C. I., Wedig, M. M., Martis, B., Shin, L. M., Wilhelm, S. et al. (2004). Amygdala responses to human faces in obsessive-compulsive disorder. Biological Psychiatry, 56, 916-920.
22. Carey, P., Seedat, S., Warwick, J., van, H. B., & Stein, D. J. (2004). SPECT imaging of body dysmorphic disorder. Journal of Neuropsychiatry and Clinical Neurosciences, 16, 357-359.
23. Chamberlain, S. R., Blackwell, A. D., Fineberg, N. A., Robbins, T. W., & Sahakian, B. J. (2005). The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neuroscience and Biobehavioral Reviews, 29, 399-419.
24. Chamberlain, S. R., Fineberg, N. A., Menzies, L. A., Blackwell, A. D., Bullmore, E. T., Robbins, T. W. et al. (2007). Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessivecompulsive disorder. American Journal of Psychiatry, 164, 335-338.
25. Chamberlain, S. R., Menzies, L., Hampshire, A., Suckling, J., Fineberg, N. A., Del, C. N. et al. (2008a). Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives. Science, 321, 421-422.
26. Chamberlain, S. R., Menzies, L. A., Fineberg, N. A., Del, C. N., Suckling, J., Craig, K. et al. (2008b). Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study. British Journal of Psychiatry, 193, 216-221.
27. Cummings, J. L. (1993). Frontal-subcortical circuits and human behavior. Arch. Neurol., 50, 873-880.
28. Dilger, S., Straube, T., Mentzel, H. J., Fitzek, C., Reichenbach, J. R., Hecht, H. et al. (2003). Brain activation to phobia-related pictures in spider phobic humans: an event-related functional magnetic resonance imaging study. Neuroscience Letters., 348, 29-32.
29. Ekman, P., & Friesen, W. V. (1976). Measuring facial movement. Environmental Psychology and Nonverbal Behavior, 1, 56-75.
30. Evans, K. C., Wright, C. I., Wedig, M. M., Gold, A. L., Pollack, M. H., & Rauch, S. L. (2008). A functional MRI study of amygdala responses to angry schematic faces in social anxiety disorder. Depression and Anxiety, 25, 496-505.
31. Feusner, J. D., Townsend, J., Bystritsky, A., & Bookheimer, S. (2007). Visual information processing of faces in body dysmorphic disorder. Archives of General Psychiatry, 64, 1417-1425.
32. Furmark, T., Tillfors, M., Marteinsdottir, I., Fischer, H., Pissiota, A., Langstrom, B. et al. (2002). Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy. Archives of General Psychiatry, 59, 425-433.
33. Gehring, W. J., Himle, J., & Nisenson, L. G. (2000). Action-monitoring dysfunction in obsessive-compulsive disorder. Psychological Science, 11, 1-6.
34. Gibbs, N. A. (1996). Nonclinical populations in research on obsessive-compulsive disorder: a critical review. Clinical Psychology Review, 16, 729-773.
35. Goossens, L., Sunaert, S., Peeters, R., Griez, E. J., & Schruers, K. R. (2007). Amygdala hyperfunction in phobic fear normalizes after exposure. Biological Psychiatry, 62, 1119-1125.
36. Goudriaan, A. E., Oosterlaan, J., de Beurs, E., & van den Brink, W. (2006). Neurocognitive functions in pathological gambling: a comparison with alcohol dependence, Tourette syndrome and normal controls. Addiction, 101, 534-547.
37. Grachev, I. D. (1997). MRI-based morphometric topographic parcellation of human neocortex in trichotillomania. Psychiatry and Clinical Neurosciences., 51, 315-321.
38. Groenewegen, H. J. & Uylings, H. B. (2000). The prefrontal cortex and the integration of sensory, limbic and autonomic information. Progress in Brain Research., 126, 3-28.
39. Gu, B. M., Park, J. Y., Kang, D. H., Lee, S. J., Yoo, S. Y., Jo, H. J. et al. (2008). Neural correlates of cognitive inflexibility during task-switching in obsessive-compulsive disorder. Brain, 131, 155-164.
40. Haber, S. N. (2008). The primate basal ganglia: parallel integrative networks. Journal of Chemical Neuroanatomy, 26, 317-330.
41. Herberg, L. J. & Blundell, J. E. (1967). Lateral hypothalamus: hoarding behavior elicited by electrical stimulation. Science, 155, 349-350.
42. Hester, R. & Garavan, H. (2004). Executive dysfunction in cocaine addiction: evidence for discordant frontal, cingulate, and cerebellar activity. Journal of Neuroscience, 24, 11017-11022.
43. Hollander, E., Braun, A., & Simeon, D. (2008). Should OCD leave the anxiety disorders in DSM-V? The case for obsessive compulsive-related disorders. Depression and Anxiety, 25, 317-329.
44. Hurd, Y. L., Suzuki, M., & Sedvall, G. C. (2001). D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain. Journal of Chemical Neuroanatomy, 22, 127-137.
45. Kalsbeek, A., De Bruin, J. P., Feenstra, M. G., Matthijssen, M. A., & Uylings, H. B. (1988). Neonatal thermal lesions of the mesolimbocortical dopaminergic projection decrease food-hoarding behavior. Brain Research, 475, 80-90.
46. Kelley, A. E. & Stinus, L. (1985). Disappearance of hoarding behavior after 6-hydroxydopamine lesions of the mesolimbic dopamine neurons and its reinstatement with L-dopa. Behavioral Neuroscience, 99, 531-545.
47. Larson, C. L., Schaefer, H. S., Siegle, G. J., Jackson, C. A., Anderle, M. J., & Davidson, R. J. (2006). Fear is fast in phobic individuals: amygdala activation in response to fear-relevant stimuli. Biological Psychiatry, 60, 410-417.
48. Leckman, J. F., Rauch, S. L., & Mataix-Cols, D. (2007). Symptom dimensions in obsessive-compulsive disorder:implications for the DSM-V. CNS Spectrums., 12, 376-87, 400.
49. LeDoux, J. E. (1996). The emotional brain: the mysterious underpinnings of emotional life. New York: Touchstone.
50. Lorberbaum, J. P., Kose, S., Johnson, M. R., Arana, G. W., Sullivan, L. K., Hamner, M. B. et al. (2004). Neural correlates of speech anticipatory anxiety in generalized social phobia. Neuroreport, 15, 2701-2705.
51. Maltby, N., Tolin, D. F., Worhunsky, P., O'Keefe, T. M., & Kiehl, K. A. (2005). Dysfunctional action monitoring hyperactivates frontal-striatal circuits in obsessive-compulsive disorder: an event-related fMRI study. Neuroimage, 24, 495-503.
52. Mataix-Cols, D., Barrios, M., Sanchez-Turet, M., Vallejo, J., & Junque, C. (1999). Reduced design fluency in subclinical obsessive-compulsive subjects. Journal of Neuropsychiatry and Clinical Neurosciences, 11, 395-397.
53. Mataix-Cols, D., Cullen, S., Lange, K., Zelaya, F., Andrew, C., Amaro, E. et al. (2003). Neural correlates of anxiety associated with obsessive-compulsive symptom dimensions in normal volunteers. Biological Psychiatry, 53, 482-493.
54. Mataix-Cols, D., Frost, R. O., Pertusa, A., Clark, L. A., Leckman, J. F., Saxena, S. et al. (2010). Hoarding disorder: a new diagnosis for DSM-V? Depression and Anxiety, 27, 556-572.
55. Mataix-Cols, D., Junque, C., Sanchez-Turet, M., Vallejo, J., Verger, K., & Barrios, M. (1999). Neuropsychological functioning in a subclinical obsessive-compulsive sample. Biological Psychiatry, 45, 898-904.
56. Mataix-Cols, D., Pertusa, A., & Leckman, J. F. (2007). Issues for DSM-V: how should obsessive-compulsive and related disorders be classified? American Journal of Psychiatry, 164, 1313-1314.
57. Mataix-Cols, D., Rauch, S. L., Manzo, P. A., Jenike, M. A., & Baer, L. (1999). Use of factor-analyzed symptom dimensions to predict outcome with serotonin reuptake inhibitors and placebo in the treatment of obsessivecompulsive disorder. American Journal of Psychiatry, 156, 1409-1416.
58. Mataix-Cols, D., Rosario-Campos, M. C., & Leckman, J. F. (2005). A multidimensional model of obsessive-compulsive disorder. American Journal of Psychiatry, 162, 228-238.
59. Mataix-Cols, D. & van den Heuvel, O. A. (2006). Common and distinct neural correlates of obsessive-compulsive and related disorders. Psychiatric Clinics of North America, 29, 391-410.
60. Mataix-Cols, D., Wooderson, S., Lawrence, N., Brammer, M. J., Speckens, A., & Phillips, M. L. (2004). Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder. Archives of General Psychiatry, 61, 564-576.
61. Mechelli, A., Price, C. J., Friston, K. J., & Ashburner, J. (2005). Voxel-based morphometry of the human brain:Methods and applications. Current Medical Imaging Reviews, 1, 105-113.
62. Menzies, L., Achard, S., Chamberlain, S. R., Fineberg, N., Chen, C. H., Del, C. N. et al. (2007). Neurocognitive endophenotypes of obsessive-compulsive disorder. Brain, 130, 3223-3236.
63. Menzies, L., Chamberlain, S. R., Laird, A. R., Thelen, S. M., Sahakian, B. J., & Bullmore, E. T. (2008a). Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofrontalstriatal model revisited. Neuroscience and Biobehavioral Reviews, 32, 525-549.
64. Menzies, L., Williams, G. B., Chamberlain, S. R., Ooi, C., Fineberg, N., Suckling, J. et al. (2008b). White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relatives. American Journal of Psychiatry, 165, 1308-1315.
65. Muller, S. V., Johannes, S., Wieringa, B., Weber, A., Muller-Vahl, K., Matzke, M. et al. (2003). Disturbed monitoring and response inhibition in patients with Gilles de la Tourette syndrome and co-morbid obsessive compulsive disorder. Behavioral Neurology, 14, 29-37.
66. Muris, P., Merckelbach, H., & Clavan, M. (1997). Abnormal and normal compulsions. Behaviour Research and Therapy, 35, 249-252.
67. O'Sullivan, R. L., Rauch, S. L., Breiter, H. C., Grachev, I. D., Baer, L., Kennedy, D. N. et al. (1997). Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging. Biological Psychiatry, 42, 39-45.
68. Ochsner, K. N. & Gross, J. J. (2005). The cognitive control of emotion. Trends in Cognitive Science, 9, 242-249.
69. Perani, D., Garibotto, V., Gorini, A., Moresco, R. M., Henin, M., Panzacchi, A. et al. (2008). In vivo PET study of 5HT(2A) serotonin and D(2) dopamine dysfunction in drug-naive obsessive-compulsive disorder. Neuroimage, 42, 306-314.
70. Pertusa, A., Fullana, M. A., Singh, S., Alonso, P., Menchon, J. M., & Mataix-Cols, D. (2008). Compulsive hoarding:OCD symptom, distinct clinical syndrome, or both? American Journal of Psychiatry, 165, 1289-1298.
71. Peterson, B. S., Choi, H. A., Hao, X., Amat, J. A., Zhu, H., Whiteman, R. et al. (2007). Morphologic features of the amygdala and hippocampus in children and adults with Tourette syndrome. Archives of General Psychiatry, 64, 1281-1291.
72. Peterson, B. S., Skudlarski, P., Anderson, A. W., Zhang, H., Gatenby, J. C., Lacadie, C. M. et al. (1998). A functional magnetic resonance imaging study of tic suppression in Tourette syndrome. Archives of General Psychiatry, 55, 326-333.
73. Peterson, B. S., Staib, L., Scahill, L., Zhang, H., Anderson, C., Leckman, J. F. et al. (2001). Regional brain and ventricular volumes in Tourette syndrome. Archives of General Psychiatry, 58, 427-440.
74. Peterson, B. S., Thomas, P., Kane, M. J., Scahill, L., Zhang, H., Bronen, R. et al. (2003). Basal ganglia volumes in patients with Gilles de la Tourette syndrome. Archives of General Psychiatry, 60, 415-424.
75. Phan, K. L., Fitzgerald, D. A., Nathan, P. J., & Tancer, M. E. (2006). Association between amygdala hyperactivity to harsh faces and severity of social anxiety in generalized social phobia. Biological Psychiatry, 59, 424-429.
76. Phelps, E. A., Delgado, M. R., Nearing, K. I., & LeDoux, J. E. (2004). Extinction learning in humans: role of the amygdala and vmPFC. Neuron, 43, 897-905.
77. Phillips, K. A., Stein, D. J., Rauch, S. L., Hollander, E., Fineberg, N., Saxena, S. et al. (2010). Should an obsessivecompulsive spectrum grouping of disorders be included in DSM-V? Depression and Anxiety, 27(6), 528-555.
78. Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003a). Neurobiology of emotion perception I: The neural basis of normal emotion perception. Biological Psychiatry, 54, 504-514.
79. Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003b). Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biological Psychiatry, 54, 515-528.
80. Phillips, M. L., Marks, I. M., Senior, C., Lythgoe, D., O'Dwyer, A. M., Meehan, O. et al. (2000). A differential neural response in obsessive-compulsive disorder patients with washing compared with checking symptoms to disgust. Psychological Medicine, 30, 1037-1050.
81. Phillips, M. L., Young, A. W., Senior, C., Brammer, M., Andrew, C., Calder, A. J. et al. (1997). A specific neural substrate for perceiving facial expressions of disgust. Nature, 389, 495-498.
82. Pujol, J., Soriano-Mas, C., Alonso, P., Cardoner, N., Menchon, J. M., Deus, J. et al. (2004). Mapping structural brain alterations in obsessive-compulsive disorder. Archives of General Psychiatry, 61, 720-730.
83. Quirk, G. J., Likhtik, E., Pelletier, J. G., & Pare, D. (2003). Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons. Journal of Neuroscience, 23, 8800-8807.
84. Quirk, G. J., Russo, G. K., Barron, J. L., & Lebron, K. (2000). The role of ventromedial prefrontal cortex in the recovery of extinguished fear. Journal of Neuroscience, 20, 6225-6231.
85. Rachman, S. & de Silva. P. (1978). Abnormal and normal obsessions. Behaviour Research and Therapy, 16, 233-248.
86. Radua, J. & Mataix-Cols, D. (2009). Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder. British Journal of Psychiatry, 195, 393-402.
87. Radua, J., van den Heuvel, O. A., Surguladze, S., & Mataix-Cols, D. (2010). Is OCD an anxiety disorder? A metaanalytical comparison of voxel-based morphometry studies in OCD vs. other anxiety disorders. Archives of General Psychiatry, 67, 701-711.
88. Rasmussen, S. A. & Eisen, J. L. (1988). Clinical and epidemiologic findings of significance to neuropharmacologic trials in OCD. Psychopharmacology Bulletin, 24, 466-470.
89. Rauch, S. L., Dougherty, D. D., Shin, L. M., Alpert, N. M., Manzo, P. A., Leahy, L. et al. (1998). Neural correlates of factor-analyzed OCD symptom dimensions: a PET study. CNS Spectrums, 3, 37-43.
90. Rauch, S. L., Phillips, K. A., Segal, E., Makris, N., Shin, L. M., Whalen, P. J. et al. (2003). A preliminary morphometric magnetic resonance imaging study of regional brain volumes in body dysmorphic disorder. Psychiatry Research, 122, 13-19.
91. Rauch, S. L., Savage, C. R., Alpert, N. M., Fischman, A. J., & Jenike, M. A. (1997). The functional neuroanatomy of anxiety: a study of three disorders using positron emission tomography and symptom provocation. Biological Psychiatry, 42, 446-452.
92. Rauch, S. L., Savage, C. R., Alpert, N. M., Miguel, E. C., Baer, L., Breiter, H. C. et al. (1995). A positron emission tomographic study of simple phobic symptom provocation. Archives of General Psychiatry, 52, 20-28.
93. Rauch, S. L., Whalen, P. J., Shin, L. M., McInerney, S. C., Macklin, M. L., Lasko, N. B. et al. (2000). Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study. Biological Psychiatry, 47, 769-776.
94. Remijnse, P. L., Nielen, M. M., van Balkom, A. J., Cath, D. C., van, O. P., Uylings, H. B. et al. (2006). Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder. Archives of General Psychiatry, 63, 1225-1236.
95. Remijnse, P. L., van den Heuvel, O. A., & Veltman, D. J. (2005). Neuroimaging in obsessive-compulsive disorder. Current Medical Imaging Reviews, 1, 331-351.
96. Rotge, J. Y., Guehl, D., Dilharreguy, B., Tignol, J., Bioulac, B., Allard, M. et al. (2009). Meta-analysis of brain volume changes in obsessive-compulsive disorder. Biological Psychiatry, 65, 75-83.
97. Roth, R. M., Saykin, A. J., Flashman, L. A., Pixley, H. S., West, J. D., & Mamourian, A. C. (2007). Event-related functional magnetic resonance imaging of response inhibition in obsessive-compulsive disorder. Biological Psychiatry, 62, 901-909.
98. Rubia, K., Smith, A. B., Brammer, M. J., Toone, B., & Taylor, E. (2005). Abnormal brain activation during inhibition and error detection in medication-naive adolescents with ADHD. American Journal of Psychiatry, 162, 1067-1075.
99. Saxena, S. (2008). Recent advances in compulsive hoarding. Current Psychiatry Reports, 10, 297-303.
100. Saxena, S., Brody, A. L., Maidment, K. M., Smith, E. C., Zohrabi, N., Katz, E. et al. (2004). Cerebral glucose metabolism in obsessive-compulsive hoarding. American Journal of Psychiatry, 161, 1038-1048.
101. Saxena, S., Gorbis, E., O'Neill, J., Baker, S. K., Mandelkern, M. A., Maidment, K. M. et al. (2009). Rapid effects of brief intensive cognitive-behavioral therapy on brain glucose metabolism in obsessive-compulsive disorder. Molecular Psychiatry, 14, 197-205.
102. Saxena, S. & Rauch, S. L. (2000). Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiatric Clinics of North America, 23, 563-586.
103. Schienle, A., Schafer, A., Walter, B., Stark, R., & Vaitl, D. (2005). Brain activation of spider phobics towards disorder-relevant, generally disgust and fear-inducing pictures. Neuroscience Letters, 388, 1-6.
104. Schneider, F., Weiss, U., Kessler, C., Muller-Gartner, H. W., Posse, S., Salloum, J. B. et al. (1999). Subcortical correlates of differential classical conditioning of aversive emotional reactions in social phobia. Biological Psychiatry, 45, 863-871.
105. Shapira, N. A., Liu, Y., He, A. G., Bradley, M. M., Lessig, M. C., James, G. A. et al. (2003). Brain activation by disgustinducing pictures in obsessive-compulsive disorder. Biological Psychiatry, 54, 751-756.
106. Shin, L. M., Orr, S. P., Carson, M. A., Rauch, S. L., Macklin, M. L., Lasko, N. B. et al. (2004). Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD. Archives of General Psychiatry, 61, 168-176.
107. Shin, L. M., Rauch, S. L., & Pitman, R. K. (2006). Amygdala, medial prefrontal cortex, and hippocampal function in PTSD. Annals of the New York Academy of Sciences, 1071, 67-79.
108. Shin, L. M., Wright, C. I., Cannistraro, P. A., Wedig, M. M., McMullin, K., Martis, B. et al. (2005). A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Archives of General Psychiatry, 62, 273-281.
109. Smith, A. B., Taylor, E., Brammer, M., Toone, B., & Rubia, K. (2006). Task-specific hypoactivation in prefrontal and temporoparietal brain regions during motor inhibition and task switching in medication-naive children and adolescents with attention deficit hyperactivity disorder. American Journal of Psychiatry, 163, 1044-1051.
110. Sowell, E. R., Kan, E., Yoshii, J., Thompson, P. M., Bansal, R., Xu, D. et al. (2008). Thinning of sensorimotor cortices in children with Tourette syndrome. Nature Neuroscience, 11, 637-639.
111. Stein, D. J., Coetzer, R., Lee, M., Davids, B., & Bouwer, C. (1997). Magnetic resonance brain imaging in women with obsessive-compulsive disorder and trichotillomania. Psychiatry Research, 74, 177-182.
112. Stein, D. J., van, H. B., Hugo, C., van, K. J., Warwick, J., Zungu-Dirwayi, N. et al. (2002). Functional brain imaging and pharmacotherapy in trichotillomania. Single photon emission computed tomography before and after treatment with the selective serotonin reuptake inhibitor citalopram. Progress in Neuro-psychopharmacology, 26, 885-890.
113. Stein, M. B., Goldin, P. R., Sareen, J., Zorrilla, L. T., & Brown, G. G. (2002). Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Archives of General Psychiatry, 59, 1027-1034.
114. Steketee, G. & Frost, R. (2003). Compulsive hoarding: current status of the research. Clinical Psychology Review, 23, 905-927.
115. Straube, T., Mentzel, H. J., Glauer, M., & Miltner, W. H. (2004). Brain activation to phobia-related words in phobic subjects. Neuroscience Letters, 372, 204-208.
116. Straube, T., Mentzel, H. J., & Miltner, W. H. (2006). Neural mechanisms of automatic and direct processing of phobogenic stimuli in specific phobia. Biological Psychiatry, 59, 162-170.
117. Swedo, S. E., Rapoport, J. L., Leonard, H. L., Schapiro, M. B., Rapoport, S. I., & Grady, C. L. (1991). Regional cerebral glucose metabolism of women with trichotillomania. Archives of General Psychiatry, 48, 828-833.
118. Tillfors, M., Furmark, T., Marteinsdottir, I., & Fredrikson, M. (2002). Cerebral blood flow during anticipation of public speaking in social phobia: a PET study. Biological Psychiatry, 52, 1113-1119.
119. Tolin, D. F., Kiehl, K. A., Worhunsky, P., Book, G. A., & Maltby, N. (2009). An exploratory study of the neural mechanisms of decision making in compulsive hoarding. Psychological Medicine, 39(2), 325-336.
120. Ursu, S., Stenger, V. A., Shear, M. K., Jones, M. R., & Carter, C. S. (2003). Overactive action monitoring in obsessive-compulsive disorder: evidence from functional magnetic resonance imaging. Psychological Science, 14, 347-353.
121. van den Heuvel, O. A., Remijnse, P. L., Mataix-Cols, D., Vrenken, H., Groenewegen, H. J., Uylings, H. B. et al. (2009). The major symptom dimensions of obsessive-compulsive disorder are mediated by partially distinct neural systems. Brain, 132, 853-868.
122. van den Heuvel, O. A., Veltman, D. J., Groenewegen, H. J., Cath, D. C., van Balkom, A. J., van, H. J. et al. (2005a). Frontal-striatal dysfunction during planning in obsessive-compulsive disorder. Archives of General Psychiatry, 62, 301-309.
123. van den Heuvel, O. A., Veltman, D. J., Groenewegen, H. J., Dolan, R. J., Cath, D. C., Boellaard, R. et al. (2004). Amygdala activity in obsessive-compulsive disorder with contamination fear: a study with oxygen-15 water positron emission tomography. Psychiatry Research, 132, 225-237.
124. van den Heuvel, O. A., Veltman, D. J., Groenewegen, H. J., Witter, M. P., Merkelbach, J., Cath, D. C. et al. (2005b). Disorder-specific neuroanatomical correlates of attentional bias in obsessive-compulsive disorder, panic disorder, and hypochondriasis. Archives of General Psychiatry, 62, 922-933.
125. van der Wee, N. J., Ramsey, N. F., Jansma, J. M., Denys, D. A., van Megen, H. J., Westenberg, H. M. et al. (2003). Spatial working memory deficits in obsessive compulsive disorder are associated with excessive engagement of the medial frontal cortex. Neuroimage, 20, 2271-2280.
126. Wendt, J., Lotze, M., Weike, A. I., Hosten, N., & Hamm, A. O. (2008). Brain activation and defensive response mobilization during sustained exposure to phobia-related and other affective pictures in spider phobia. Psychophysiology, 45, 205-215.
127. Whiteside, S. P., Port, J. D., & Abramowitz, J. S. (2004). A meta-analysis of functional neuroimaging in obsessivecompulsive disorder. Psychiatry Research, 132, 69-79.
128. Wicker, B., Keysers, C., Plailly, J., Royet, J. P., Gallese, V., & Rizzolatti, G. (2003). Both of us disgusted in my insula:the common neural basis of seeing and feeling disgust. Neuron, 40, 655-664.
129. Woody, S. R., McLean, C., & Klassen, T. (2005). Disgust as a motivator of avoidance of spiders. Journal of Anxiety Disorders, 19, 461-475.
130. Wright, C. I., Martis, B., McMullin, K., Shin, L. M., & Rauch, S. L. (2003). Amygdala and insular responses to emotionally valenced human faces in small animal specific phobia. Biological Psychiatry, 54, 1067-1076.