Brain activation and defensive response mobilization during sustained exposure to phobia-related and other affective pictures in spider phobia

Psychophysiology

Volumn 45, Issue 2, 2008, Pages 205-215

  Wendt, Julia ^a   Lotze, Martin ^a   Weike, Almut I ^a   Hosten, Norbert ^a   Hamm, Alfons O ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Amygdala; fMRI; Insula; Spider phobia; Startle

Indexed keywords

ADULT; AMYGDALOID NUCLEUS; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CLINICAL ARTICLE; CONTROLLED STUDY; DEFENSIVE BEHAVIOR; ELECTROENCEPHALOGRAM; FEMALE; HUMAN; PHOBIA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPIDER;

ADULT; AFFECT; ANIMALS; BRAIN; ELECTROMYOGRAPHY; EMOTIONS; FEMALE; HEART RATE; HUMANS; MAGNETIC RESONANCE IMAGING; PHOBIC DISORDERS; PHOTIC STIMULATION; PSYCHIATRIC STATUS RATING SCALES; SPIDERS; STARTLE REACTION;

EID: 38849083986     PISSN: 00485772     EISSN: 14698986     Source Type: Journal    
DOI: 10.1111/j.1469-8986.2007.00620.x     Document Type: Article

References (64)

1. Adolphs, R. Spezio, M. (2006). Role of the amygdala in processing visual social stimuli. Progress in Brain Research, 156, 363 378.
2. Anders, S., Lotze, M., Erb, M., Grodd, W. Birbaumer, N. (2004). Brain activity underlying emotional valence and arousal: A response-related fMRI study. Human Brain Mapping, 23, 200 209.
3. Birbaumer, N., Veit, R., Lotze, M., Erb, M., Hermann, C., Grodd, W., et al 2005). Deficient fear conditioning in psychopathy: A functional magnetic resonance imaging study. Archives of General Psychiatry, 62, 799 805.
4. Bradley, M. M., Cuthbert, B. N. Lang, P. J. (1996). Picture media and emotion: Effects of a sustained affective context. Psychophysiology, 33, 662 670.
5. Bradley, M. M. Lang, P. J. (1994). Measuring emotion: The self-assessment manikin and the semantic differential. Journal of Behavior Therapy and Experimental Psychiatry, 25, 49 59.
6. Buchanan, T. W., Tranel, D. Adolphs, R. (2004). Anteromedial temporal lobe damage blocks startle modulation by fear and disgust. Behavioral Neuroscience, 118, 429 437.
7. Büchel, C., Morris, J., Dolan, R. J. Friston, K. J. (1998). Brain systems mediating aversive conditioning: An event-related fMRI study. Neuron, 20, 947 957.
8. Carlsson, K., Petersson, K. M., Lundqvist, D., Karlsson, A., Ingvar, M. Öhman, A. (2004). Fear and the amygdala: Manipulation of awareness generates differential cerebral responses to phobic and fear-relevant (but nonfeared) stimuli. Emotion, 4, 340 353.
9. Craig, A. D. (2002). How do you feel? Interoception: The sense of the physiological condition of the body. Nature Reviews. Neuroscience, 3, 655 666.
10. Critchley, H. D. (2005). Neural mechanisms of autonomic, affective, and cognitive integration. Journal of Comparative Neurology, 493, 154 166.
11. Critchley, H. D., Wiens, S., Rotshtein, P., Öhman, A. Dolan, R. J. (2004). Neural systems supporting interoceptive awareness. Nature Neuroscience, 7, 189 195.
12. Davis, K. D., Kwan, C. L., Crawley, A. P. Mikulis, D. J. (1998). Event-related fMRI of pain: Entering a new era in imaging pain. NeuroReport, 9, 3019 3023.
13. Davis, M. (2000). The role of the amygdala in conditioned and unconditioned fear and anxiety. In J. P. Aggleton (Ed.), The amygdala: A functional analysis (2nd ed, pp. 213 287). Oxford : Oxford University Press.
14. Davis, M. Whalen, P. J. (2001). The amygdala: Vigilance and emotion. Molecular Psychiatry, 6, 13 34.
15. Dilger, S., Straube, T., Mentzel, H.-J., Fitzek, C., Reichenbach, J. R., Hecht, H., et al 2003). Brain activation to phobia-related pictures in spider phobic humans: An event-related functional magnetic resonance imaging study. Neuroscience Letters, 348, 29 32.
16. Duncan, S. L. Barrett, L. F. (2007). The amygdala in visual awareness. Trends in Cognitive Sciences, 11, 190 192.
17. Fredrikson, M. (1981). Orienting and defense reactions to phobic and conditioned fear stimuli in phobics and normals. Psychophysiology, 18, 456 465.
18. Fredrikson, M. Furmark, T. (2003). Amygdaloid regional cerebral blood flow and subjective fear during symptom provocation in anxiety disorders. Annals of the New York Academy of Science, 985, 341 347.
19. Fridlund, A. J. Cacioppo, J. T. (1986). Guidelines for human electromyographic research. Psychophysiology, 23, 567 589.
20. Funayama, E. S., Grillon, C., Davis, M. Phelps, E. A. (2001). A double dissociation in the affective modulation of startle in humans: Effects of unilateral temporal lobectomy. Journal of Cognitive Neuroscience, 13, 721 729.
21. Genovese, C. R., Lazar, N. A. Nichols, T. (2002). Thresholding of statistical maps in functional neuroimaging using the false discovery rate. NeuroImage, 15, 870 878.
22. Globisch, J., Hamm, A. O., Esteves, F. Öhman, A. (1999). Fear appears fast: Temporal course of startle reflex potentiation in animal fearful subjects. Psychophysiology, 36, 66 75.
23. Globisch, J., Hamm, A. O., Schneider, R. Vaitl, D. (1993). A computer program for scoring reflex eyeblink and electrodermal responses written in PASCAL [Abstract]. Psychophysiology, 30 (Suppl.), 13.
24. Hamann, S. B., Ely, T. D., Grafton, S. T. Kilts, C. D. (1999). Amygdala activity to enhanced memory for pleasant and aversive stimuli. Nature Neuroscience, 2, 289 293.
25. Hamm, A. O. (2006). Spezifische Phobien [Specific Phobias]. Göttingen : Hogrefe Verlag.
26. Hamm, A. O., Cuthbert, B. N., Globisch, J. Vaitl, D. (1997). Fear and the startle reflex: Blink modulation and autonomic response patterns in animal and mutilation fearful subjects. Psychophysiology, 34, 97 107.
27. Koelsch, S., Fritz, T., von Cramon, D. Y., Müller, K. Friederici, A. D. (2006). Investigating emotion with music: An fMRI study. Human Brain Mapping, 27, 239 250.
28. Lang, P. J., Bradley, M. M. Cuthbert, B. N. (2005). International affective picture system (IAPS): Digitized photographs, instruction manual and affective ratings. Technical Report A-6. Gainesville, FL: University of Florida.
29. Larson, C. L., Schaefer, H. S., Siegle, G. J., Jackson, C. A., Anderle, M. J. Davidson, R. J. (2006). Fear is fast in phobic individuals: Amygdala activation in response to fear-relevant stimuli. Biological Psychiatry, 60, 410 417.
30. LeDoux, J. E. (1996). The emotional brain. New York : Simon & Schuster.
31. Liberzon, I., Phan, K. L., Decker, L. R. Taylor, S. F. (2003). Extended amygdala and emotional salience: A PET investigation of positive and negative affect. Neuropsychopharmacology, 28, 726 733.
32. Lykken, D. T., Rose, R. J., Luther, B. Maley, M. (1966). Correcting psychophysiological measures for individual differences in range. Psychological Bulletin, 66, 481 484.
33. Maren, S. Quirk, G. J. (2004). Neuronal signalling of fear memory. Nature Reviews. Neuroscience, 5, 844 852.
34. Morris, J. S., Öhman, A. Dolan, R. J. (1998). Conscious and unconscious emotional learning in the human amygdala. Nature, 393, 467 470.
35. Nitschke, J. B., Sarinopoulos, I., Mackiewicz, K. L., Schaefer, H. S. Davidson, R. J. (2006). Functional neuroanatomy of aversion and its anticipation. NeuroImage, 29, 106 116.
36. Öhman, A. Mineka, S. (2001). Fears, phobias, and preparedness: Toward an evolved module of fear and fear learning. Psychological Review, 108, 483 522.
37. Paulus, M. P. Stein, M. B. (2006). An insular view of anxiety. Biological Psychiatry, 60, 383 387.
38. Pessoa, L., Japee, S., Sturman, D. Ungerleider, L. G. (2006). Target visibility and visual awareness modulate amygdala responses to fearful faces. Cerebral Cortex, 16, 366 375.
39. Peyron, R., Laurent, B. Garcia-Larrea, L. (2000). Functional imaging of brain responses to pain. A review and meta-analysis. Neurophysiologie Clinique, 30, 263 288.
40. Phan, K. L., Wager, T., Taylor, S. F. Liberzon, I. (2002). Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI. NeuroImage, 16, 331 348.
41. Phelps, E. A., O'Connor, K. J., Gatenby, J. C., Gore, J. C., Grillon, C. Davis, M. (2001). Activation of the left amygdala to a cognitive representation of fear. Nature Neuroscience, 4, 437 441.
42. Rauch, S. L., Savage, C. R., Alpert, N. M., Fischman, A. J. Jenike, M. A. (1997). The functional neuroanatomy of anxiety: A study of three disorders using positron emission tomography and symptom provocation. Biological Psychiatry, 42, 446 452.
43. Rauch, S. L., Savage, C. R., Alpert, N. M., Miguel, E. C., Baer, L., Breiter, H. C., et al 1995). A positron emission tomographic study of simple phobic symptom provocation. Archives of General Psychiatry, 52, 20 28.
44. Reynolds, S. M. Zahm, D. S. (2005). Specificity in the projections of prefrontal and insular cortex to ventral striatopallidum and the extended amygdala. Journal of Neuroscience, 25, 11757 11767.
45. Rosen, J. B. Schulkin, J. (1998). From normal fear to pathological anxiety. Psychological Review, 105, 325 350.
46. Sabatinelli, D., Bradley, M. M., Fitzsimmons, J. R. Lang, P. J. (2005). Parallel amygdala and inferotemporal activation reflect emotional intensity and fear relevance. NeuroImage, 24, 1265 1270.
47. Sabatinelli, D., Bradley, M. M. Lang, P. J. (2001). Affective startle modulation in anticipation and perception. Psychophysiology, 38, 719 722.
48. Schienle, A., Schäfer, A., Stark, R., Walter, B. Vaitl, D. (2005). Neural responses of OCD patients towards disorder-relevant, generally disgust-inducing and fear-inducing pictures. International Journal of Psychophysiology, 57, 69 77.
49. Schienle, A., Schäfer, A., Walter, B., Stark, R. Vaitl, D. (2005). Brain activation of spider phobics towards disorder-relevant, generally disgust- and fear-inducing pictures. Neuroscience Letters, 388, 1 6.
50. Schienle, A., Stark, R., Walter, B., Blecker, C., Ott, U., Kirsch, P., et al 2002). The insula is not specifically involved in disgust processing: An fMRI study. NeuroReport, 13, 2023 2026.
51. Shi, C. J. Cassell, M. D. (1998). Cortical, thalamic, and amygdaloid connections of the anterior and posterior insular cortices. Journal of Comparative Neurology, 399, 440 468.
52. Shimizu, H. (1978). Reliable and precise identification of R-waves in the EKG with a simple peak detector. Psychophysiology, 15, 499 501.
53. Simmons, A., Strigo, I., Matthews, S. C., Paulus, M. P. Stein, M. B. (2006). Anticipation of aversive visual stimuli is associated with increased insula activation in anxiety-prone subjects. Biological Psychiatry, 60, 402 409.
54. Smith, J. C., Bradley, M. M. Lang, P. J. (2005). State anxiety and affective physiology: Effects of sustained exposure to affective pictures. Biological Psychiatry, 69, 247 260.
55. Stark, R., Schienle, A., Girod, C., Walter, B., Kirsch, P., Blecker, C., et al 2005). Erotic and disgust-inducing pictures - Differences in the hemodynamic responses of the brain. Biological Psychology, 70, 19 29.
56. Stein, M. B., Simmons, A. N., Feinstein, J. S. Paulus, M. P. (2007). Increased amygdala and insula activation during emotion processing in anxiety-prone subjects. American Journal of Psychiatry, 164, 318 327.
57. Straube, T., Glauer, M., Dilger, S., Mentzel, H.-J. Miltner, W. H. R. (2006). Effects of cognitive-behavioral therapy on brain activation in specific phobia. NeuroImage, 29, 125 135.
58. Straube, T., Mentzel, H.-J. Miltner, W. H. R. (2006). Neural mechanisms of automatic and direct processing of phobogenic stimuli in specific phobia. Biological Psychiatry, 59, 162 170.
59. Sutton, S. K., Davidson, R. J., Donzella, B., Irwin, W. Dottle, D. A. (1997). Manipulating affective state using extended picture presentation. Psychophysiology, 34, 217 226.
60. Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., et al 2002). Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. NeuroImage, 15, 273 289.
61. Venables, P. H. Christie, M. J. (1980). Electrodermal activity. In I. Martin P. H. Venables (Eds.), Techniques in psychophysiology (pp. 4 67). New York : Wiley.
62. Weike, A. I., Hamm, A. O., Schupp, H. T., Runge, U., Schroeder, H. W. S. Kessler, C. (2005). Fear conditioning following unilateral temporal lobectomy: Dissociation of conditioned startle potentiation and autonomic learning. Journal of Neuroscience, 25, 11117 11124.
63. Whalen, P. J., Rauch, S. L., Etcoff, N. L., McInerney, S. C., Lee, M. Jenike, M. A. (1998). Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. Journal of Neuroscience, 18, 411 418.
64. Yang, T. T., Menon, V., Eliez, S., Blasey, C., White, C. D., Reid, A. J., et al 2002). Amygdalar activation associated with positive and negative facial expressions. NeuroReport, 13, 1737 1741.