Brain activation to phobia-related pictures in spider phobic humans: An event-related functional magnetic resonance imaging study

Neuroscience Letters

Volumn 348, Issue 1, 2003, Pages 29-32

  Dilger, Stefan ^a   Straube, Thomas ^a   Mentzel, Hans Joachim ^a   Fitzek, Clemens ^a   Reichenbach, Jürgen R ^a   Hecht, Holger ^a   Krieschel, Silke ^a   Gutberlet, Ingmar ^b   Miltner, Wolfgang H R ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b Brain Products GmbH   (Germany)

Author keywords

Amygdala; Anxiety; Event related functional magnetic resonance imaging; Insula; Spider phobia

Indexed keywords

AMYGDALOID NUCLEUS; ARTICLE; BRAIN FUNCTION; EVOKED RESPONSE; FEAR; HUMAN; HUMAN EXPERIMENT; INSULA; NUCLEAR MAGNETIC RESONANCE IMAGING; ORBITAL CORTEX; OXYGEN BLOOD LEVEL; PHOBIA; PRIORITY JOURNAL; VISUAL STIMULATION; ADULT; ANIMAL; BRAIN; BRAIN MAPPING; CASE CONTROL STUDY; COMPARATIVE STUDY; EMOTION; FEMALE; HEMISPHERIC DOMINANCE; HISTOLOGY; METHODOLOGY; PATHOPHYSIOLOGY; PHOTOSTIMULATION; PHYSIOLOGY; SPIDER;

ADULT; ANIMALS; BRAIN; BRAIN MAPPING; CASE-CONTROL STUDIES; EMOTIONS; EVOKED POTENTIALS; FEMALE; FUNCTIONAL LATERALITY; HUMANS; MAGNETIC RESONANCE IMAGING; PHOBIC DISORDERS; PHOTIC STIMULATION; SPIDERS;

EID: 0042385061     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(03)00647-5     Document Type: Article

References (25)

1. Birbaumer N., Grodd W., Diedrich O., Klose U., Erb M., Lotze M., Schneider F., Weiss U., Flor H. fMRI reveals amygdala activation to human faces in social phobics. NeuroReport. 9:1998;1223-1226.
2. Breiter H.C., Etcoff N.L., Whalen P.J., Kennedy W.A., Rauch S.L., Buckner R.L., Strauss M.M., Hyman S.E., Rosen B.R. Response and habituation of the human amygdala during visual processing of facial expression. Neuron. 17:1996;875-887.
3. Büchel C., Dolan R.J. Classical fear conditioning in functional neuroimaging. Curr. Opin. Neurobiol. 10:2000;219-223.
4. Canli T., Zhao Z., Desmond J.E., Glover G., Gabrieli J.E. fMRI identifies a network of structures correlated with retention of positive and negative emotional memory. Psychobiology. 27:1999;441-452.
5. Critchley H.D., Mathias C.J., Dolan R.J. Fear conditioning in humans: the influence of awareness and autonomic arousal on functional neuroanatomy. Neuron. 33:2002;653-663.
6. Damasio A.R., Grabowski T.J., Bechara A., Damasio H., Ponto L.L.B., Parvici J., Hichwa R.D. Subcortical and cortical brain activity during the feeling of self-generated emotions. Nat. Neurosci. 3:2000;1049-1056.
7. Franke G.H. SCL-90-R - Die Symptom-Checkliste von Derogatis. 1995;Deutsche Version, Hogrefe, Göttingen.
8. Fredrikson M., Wik G., Annas P., Ericson K., Stone-Elander S. Functional neuroanatomy of visually elicited simple phobic fear: additional data and theoretical analysis. Psychophysiology. 32:1995;43-48.
9. Fredrikson M., Wik G., Greitz T., Eriksson L., Stone-Elander S., Ericson K., Sedvall G. Regional cerebral blood flow during experimental phobic fear. Psychophysiology. 30:1993;126-130.
10. Josephs O., Henson R.N. Event-related functional magnetic resonance imaging: modelling, inference and optimisation. Philos. Trans. R. Soc. B. 29:1999;1215-1228.
11. Klorman R., Weerts T.C., Hastings J.E., Melamed B.G., Lang P.J. Psychometric description of some specific-fear questionnaires. Behav. Ther. 5:1974;401-409.
12. Lang P.J., Bradley M.M., Fitzsimmons J.R., Cuthbert B.N., Scott J.D., Moulder B., Nangia V. Emotional arousal and activation of the visual cortex: an fMRI analysis. Psychophysiology. 35:1998;199-210.
13. LeDoux J.E. The Emotional Brain. 1996;Simon & Schuster, New York.
14. Morris J.S., Öhman A., Dolan R.J. Conscious and unconscious emotional learning in the human amygdala. Nature. 393:1998;467-470.
15. Öhman A., Mineka S. Fears, phobias, and preparedness: toward an evolved module of fear and fear learning. Psychol. Rev. 108:2001;483-522.
16. Paquette V., Levesque J., Mensour B., Leroux J.M., Beaudoin G., Bourgouin P., Beauregard M. 'Change the mind and you change the brain': effects of cognitive-behavioral therapy on the neural correlates of spider phobia. Neuroimage. 18:2003;401-409.
17. Phelps E.A., O'Connor K.J., Gatenby J.C., Gore J.C., Grillon C., Davis M. Activation of the left amygdala to a cognitive representation of fear. Nat. Neurosci. 4:2001;437-441.
18. Phillips M.L., Young A.W., Senior C., Brammer M., Andrew C., Calder A.J., Bullmore E.T., Perrett D.I., Rowland D., Williams S.C., Gray J.A., David A.S. A specific neural substrate for perceiving facial expressions of disgust. Nature. 389:1997;495-498.
19. Schienle A., Stark R., Walter B., Blecker U., Ott P., Kirsch P., Sammer G., Vaitl D. The insula is not specifically involved in disgust processing: an fMRI study. NeuroReport. 13:2002;2023-2026.
20. Stein M.B., Goldin P.R., Sareen J., Eyler L.T., Brown G.G. Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Arch. Gen. Psychiatry. 59:2002;1027-1034.
21. Talairach J., Tournoux P. Co-Planar Stereotactic Atlas of the Human Brain. 1988;Thieme, New York.
22. Veit R., Flor H., Erb M., Hermann C., Lotze M., Grodd W., Birbaumer N. Brain circuits involved in emotional learning in antisocial behavior and social phobia in humans. Neurosci. Lett. 328:2002;233-236.
23. Wik G., Fredrikson M., Ericson K., Ericson L., Stone-Elander S., Greitz T. A functional cerebral response to frightening visual stimulation. Psychiatry Res. 50:1993;15-24.
24. Wittchen H.U., Zaudig M., Fydrich T. Strukturiertes klinisches Interview für DSM-IV. 1996;Hogrefe, Göttingen.
25. Zalla T., Koechlin E., Pietrini P., Basso G., Aquino P., Sirigu A., Grafman J. Differential amygdala responses to winning and losing: a functional magnetic resonance imaging study in humans. Eur. J. Neurosci. 12:2000;1764-1770.