Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke

Acta Neuropathologica

Volumn 129, Issue 2, 2015, Pages 259-277

  Neumann, Jens ^a   Riek Burchardt, Monika ^b,c   Herz, Josephine ^d   Doeppner, Thorsten R ^d   König, Rebecca ^b,e   Hütten, Heiko ^a   Etemire, Eloho ^d   Männ, Linda ^d   Klingberg, Anika ^d   Fischer, Thomas ^a   Görtler, Michael W ^a   Heinze, Hans Jochen ^a   Reichardt, Peter ^c   Schraven, Burkhart ^c   Hermann, Dirk M ^d   Reymann, Klaus G ^b,e   Gunzer, Matthias ^d  

^a UNIVERSITY HOSPITAL MAGDEBURG   (Germany)

^b LEIBNIZ INSTITUTE FOR NEUROBIOLOGY   (Germany)

^c OTTO VON GUERICKE UNIVERSITY   (Germany)

^d UNIVERSITY OF DUISBURG ESSEN   (Germany)

^e GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

Author keywords

Intravital 2 photon microscopy; Neutrophils; Stroke; VLA 4

Indexed keywords

ANTIGEN; UNCLASSIFIED DRUG; VERY LATE ANTIGEN 4; VERY LATE ACTIVATION ANTIGEN 4;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BLOOD BRAIN BARRIER; BONE MARROW CELL; BRAIN; BRAIN ISCHEMIA; EXPERIMENTAL STROKE; MALE; MICROGLIA; MICROSCOPY; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; CELL ADHESION; CEREBROVASCULAR ACCIDENT; CONVALESCENCE; DISEASE MODEL; IMMUNOLOGY; METABOLISM; MOTOR ACTIVITY; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; TRANSGENIC MOUSE;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; BRAIN ISCHEMIA; CELL ADHESION; DISEASE MODELS, ANIMAL; INTEGRIN ALPHA4BETA1; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; MOTOR ACTIVITY; NEUTROPHIL INFILTRATION; NEUTROPHILS; RANDOM ALLOCATION; RECOVERY OF FUNCTION; STROKE;

EID: 84923261298     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-014-1355-2     Document Type: Article

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