Development and evaluation of mucoadhesive nanoparticles based on thiolated Eudragit for oral delivery of protein drugs

Journal of Nanoparticle Research

Volumn 17, Issue 2, 2015, Pages 1-11

  Zhang, Yan ^a,b,c   Yang, Zhijie ^b   Hu, Xi ^b   Zhang, Ling ^b   Li, Feng ^a   Li, Meimei ^a   Tang, Xing ^b   Xiao, Wei ^c  

^a SHENYANG UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c JIANGSU KANION PHARMACEUTICAL CO   (China)

Author keywords

Enzymatic inhibition; Eudragit L100 cysteine; Mucoadhesive; Nanomedicine; Nanoparticles; pH sensitive

Indexed keywords

AMINO ACIDS; CONTROLLED DRUG DELIVERY; INSULIN; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; PH SENSORS; PROTEINS; X RAY PHOTOELECTRON SPECTROSCOPY;

BINDING EFFICIENCY; ENZYMATIC DEGRADATION; EUDRAGIT L100; MUCOADHESIVE; NANOPARTICLE (NPS); NETWORK STRUCTURES; ORAL ADMINISTRATION; PH SENSITIVE;

TARGETED DRUG DELIVERY;

CYSTEINE; EUDRAGIT; GLUTATHIONE; INSULIN; PROTEINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BINDING AFFINITY; CALCIUM BINDING; CONTROLLED STUDY; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG MECHANISM; ENZYMATIC DEGRADATION; ENZYME INHIBITION; MUCOADHESION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTICLE SIZE; PH; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; STATIC ELECTRICITY; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION; X RAY PHOTOELECTRON SPECTROSCOPY;

EID: 84923228514     PISSN: 13880764     EISSN: 1572896X     Source Type: Journal    
DOI: 10.1007/s11051-015-2909-5     Document Type: Article

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