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Volumn 9, Issue , 2015, Pages 1177-1184

Liraglutide reduces lipogenetic signals in visceral adipose of db/db mice with AMPK activation and akt suppression

Author keywords

AMP activated protein kinase; Lipogenesis; Liraglutide; Visceral adipose tissue

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; COMPLEMENTARY DNA; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIRAGLUTIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; RNA; LIPID;

EID: 84923210591     PISSN: 11778881     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S79175     Document Type: Article
Times cited : (23)

References (43)
  • 1
    • 33846422032 scopus 로고    scopus 로고
    • Obesity and diabetes in the developing world-a growing challenge
    • Hossain P, Kawar B, El Nahas M. Obesity and diabetes in the developing world-a growing challenge. N Engl J Med. 2007;356 (3):213-215.
    • (2007) N Engl J Med , vol.356 , Issue.3 , pp. 213-215
    • Hossain, P.1    Kawar, B.2    El Nahas, M.3
  • 2
    • 0033849777 scopus 로고    scopus 로고
    • Obesity and insulin resistance
    • Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Invest. 2000;106 (4):473-481.
    • (2000) J Clin Invest , vol.106 , Issue.4 , pp. 473-481
    • Kahn, B.B.1    Flier, J.S.2
  • 3
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman PG. Obesity as a medical problem. Nature. 2000;404 (6778):635-643.
    • (2000) Nature , vol.404 , Issue.6778 , pp. 635-643
    • Kopelman, P.G.1
  • 4
    • 0037223174 scopus 로고    scopus 로고
    • Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001
    • Mokdad AH, Ford ES, Bowman BA, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA. 2003;289 (1):76-79.
    • (2003) JAMA , vol.289 , Issue.1 , pp. 76-79
    • Mokdad, A.H.1    Ford, E.S.2    Bowman, B.A.3
  • 5
    • 2942657650 scopus 로고    scopus 로고
    • Medical consequences of obesity
    • Bray GA. Medical consequences of obesity. J Clin Endocrinol Metab. 2004;89 (6):2583-2589.
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.6 , pp. 2583-2589
    • Bray, G.A.1
  • 6
    • 33846025092 scopus 로고    scopus 로고
    • Primary prevention of cardiovascular diseases in people with diabetes mellitus: A scientific statement from the American Heart Association and the American Diabetes Association
    • Buse JB, Ginsberg HN, Bakris GL, et al. Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association. Diabetes Care. 2007;30 (1):162-172.
    • (2007) Diabetes Care , vol.30 , Issue.1 , pp. 162-172
    • Buse, J.B.1    Ginsberg, H.N.2    Bakris, G.L.3
  • 7
    • 19244387253 scopus 로고
    • Visceral fat obesity: Anthropological and pathophysiological aspects
    • Tarui S, Tokunaga K, Fujioka S, Matsuzawa Y. Visceral fat obesity: anthropological and pathophysiological aspects. Int J Obes. 1991;15 Suppl 2:1-8.
    • (1991) Int J Obes , vol.15 , pp. 1-8
    • Tarui, S.1    Tokunaga, K.2    Fujioka, S.3    Matsuzawa, Y.4
  • 8
    • 67650227632 scopus 로고    scopus 로고
    • New computed tomography-derived indices to predict cardiovascular and insulin-resistance risks in overweight/obese patients
    • Piernas C, Hernández-Morante JJ, Canteras M, Zamora S, Garaulet M. New computed tomography-derived indices to predict cardiovascular and insulin-resistance risks in overweight/obese patients. Eur J Clin Nutr. 2009;63 (7):887-897.
    • (2009) Eur J Clin Nutr , vol.63 , Issue.7 , pp. 887-897
    • Piernas, C.1    Hernández-Morante, J.J.2    Canteras, M.3    Zamora, S.4    Garaulet, M.5
  • 9
    • 80054911514 scopus 로고    scopus 로고
    • Forming functional fat: A growing understanding of adipocyte differentiation
    • Cristancho AG, Lazar MA. Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol. 2011;12 (11):722-734.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , Issue.11 , pp. 722-734
    • Cristancho, A.G.1    Lazar, M.A.2
  • 10
    • 14844282050 scopus 로고    scopus 로고
    • Regulation of PPARgamma activity during adipogenesis
    • Farmer SR. Regulation of PPARgamma activity during adipogenesis. Int J Obes (Lond). 2005;29 Suppl 1:S13-S16.
    • (2005) Int J Obes (Lond). , vol.29 , pp. S13-S16
    • Farmer, S.R.1
  • 11
    • 33748942837 scopus 로고    scopus 로고
    • Transcriptional control of adipocyte formation
    • Farmer SR. Transcriptional control of adipocyte formation. Cell Metab. 2006;4 (4):263-273.
    • (2006) Cell Metab , vol.4 , Issue.4 , pp. 263-273
    • Farmer, S.R.1
  • 12
    • 0347318052 scopus 로고    scopus 로고
    • The AMP-activated protein kinase cascade-a unifying system for energy control
    • Carling D. The AMP-activated protein kinase cascade-a unifying system for energy control. Trends Biochem Sci. 2004;29 (1):18-24.
    • (2004) Trends Biochem Sci , vol.29 , Issue.1 , pp. 18-24
    • Carling, D.1
  • 13
    • 33745225026 scopus 로고    scopus 로고
    • AMP-activated protein kinase-development of the energy sensor concept
    • ({t 1):
    • Hardie DG, Hawley SA, Scott JW. AMP-activated protein kinase-development of the energy sensor concept. J Physiol. 2006;574 ({t 1):7-15.
    • (2006) J Physiol , vol.574 , pp. 7-15
    • Hardie, D.G.1    Hawley, S.A.2    Scott, J.W.3
  • 14
    • 0031007065 scopus 로고    scopus 로고
    • The AMP-activated protein kinase-fuel gauge of the mammalian cell?
    • Hardie DG, Carling D. The AMP-activated protein kinase-fuel gauge of the mammalian cell? Eur J Biochem. 1997;246 (2):259-273.
    • (1997) Eur J Biochem , vol.246 , Issue.2 , pp. 259-273
    • Hardie, D.G.1    Carling, D.2
  • 15
    • 27544473360 scopus 로고    scopus 로고
    • Involvement of AMP-activated protein kinase in fat depot-specific metabolic changes during starvation
    • Sponarova J, Mustard KJ, Horakova O, et al. Involvement of AMP-activated protein kinase in fat depot-specific metabolic changes during starvation. FEBS Lett. 2005;579 (27):6105-6110.
    • (2005) FEBS Lett , vol.579 , Issue.27 , pp. 6105-6110
    • Sponarova, J.1    Mustard, K.J.2    Horakova, O.3
  • 16
    • 33745183847 scopus 로고    scopus 로고
    • Functions of AMP-activated protein kinase in adipose tissue
    • Daval M, Foufelle F, Ferre P. Functions of AMP-activated protein kinase in adipose tissue. J Physiol. 2006;574 (Pt 1):55-62.
    • (2006) J Physiol , vol.574 , pp. 55-62
    • Daval, M.1    Foufelle, F.2    Ferre, P.3
  • 17
    • 21644455008 scopus 로고    scopus 로고
    • Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes
    • Daval M, Diot-Dupuy F, Bazin R, et al. Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. J Biol Chem. 2005;280 (26):25250-25257.
    • (2005) J Biol Chem , vol.280 , Issue.26 , pp. 25250-25257
    • Daval, M.1    Diot-Dupuy, F.2    Bazin, R.3
  • 18
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
    • Flint A, Raben A, Astrup A, Holst JJ. Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J Clin Invest. 1998;101 (3):515-520.
    • (1998) J Clin Invest , vol.101 , Issue.3 , pp. 515-520
    • Flint, A.1    Raben, A.2    Astrup, A.3    Holst, J.J.4
  • 19
    • 0028838030 scopus 로고
    • Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients
    • Herrmann C, Göke R, Richter G, Fehmann HC, Arnold R, Göke B. Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients. Digestion. 1995;56 (2):117-126.
    • (1995) Digestion , vol.56 , Issue.2 , pp. 117-126
    • Herrmann, C.1    Göke, R.2    Richter, G.3    Fehmann, H.C.4    Arnold, R.5    Göke, B.6
  • 21
    • 3042617876 scopus 로고    scopus 로고
    • The potential role of glucagon-like peptide 1 in diabetes
    • Meier JJ, Nauck MA. The potential role of glucagon-like peptide 1 in diabetes. Curr Opin Investig Drugs. 2004;5 (4):402-410.
    • (2004) Curr Opin Investig Drugs , vol.5 , Issue.4 , pp. 402-410
    • Meier, J.J.1    Nauck, M.A.2
  • 22
    • 0036189831 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men
    • Agersø H, Jensen LB, Elbrønd B, Rolan P, Zdravkovic M. The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men. Diabetologia. 2002;45 (2):195-202.
    • (2002) Diabetologia , vol.45 , Issue.2 , pp. 195-202
    • Agersø, H.1    Jensen, L.B.2    Elbrønd, B.3    Rolan, P.4    Zdravkovic, M.5
  • 23
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU)
    • Marre M, Shaw J, Brändle M, et al. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU). Diabet Med. 2009;26 (3):268-278.
    • (2009) Diabet Med , vol.26 , Issue.3 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brändle, M.3
  • 24
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: The LEAD (liraglutide effect and action in diabetes)-2 study
    • Nauck M, Frid A, Hermansen K, et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study. Diabetes Care. 2009;32 (1):84-90.
    • (2009) Diabetes Care , vol.32 , Issue.1 , pp. 84-90
    • Nauck, M.1    Frid, A.2    Hermansen, K.3
  • 25
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • Garber A, Henry R, Ratner R, et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet. 2009;373 (9662):473-481.
    • (2009) Lancet , vol.373 , Issue.9662 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3
  • 26
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
    • Zinman B, Gerich J, Buse JB, et al. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care. 2009;32 (7):1224-1230.
    • (2009) Diabetes Care , vol.32 , Issue.7 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3
  • 27
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): A randomised controlled trial
    • Russell-Jones D, Vaag A, Schmitz O, et al. Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial. Diabetologia. 2009;52 (10):2046-2055.
    • (2009) Diabetologia , vol.52 , Issue.10 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3
  • 28
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse JB, Rosenstock J, Sesti G, et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet. 2009;374 (9683):39-47.
    • (2009) Lancet , vol.374 , Issue.9683 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3
  • 29
    • 82355160875 scopus 로고    scopus 로고
    • Short-term effects of liraglutide on visceral fat adiposity, appetite, and food preference: A pilot study of obese Japanese patients with type 2 diabetes
    • Inoue K, Maeda N, Kashine S, et al. Short-term effects of liraglutide on visceral fat adiposity, appetite, and food preference: a pilot study of obese Japanese patients with type 2 diabetes. Cardiovasc Diabetol. 2011;10:109.
    • (2011) Cardiovasc Diabetol , vol.10 , pp. 109
    • Inoue, K.1    Maeda, N.2    Kashine, S.3
  • 30
    • 70450190143 scopus 로고    scopus 로고
    • Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue
    • Jendle J, Nauck MA, Matthews DR, et al. Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue. Diabetes Obes Metab. 2009;11 (12):1163-1172.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.12 , pp. 1163-1172
    • Jendle, J.1    Nauck, M.A.2    Matthews, D.R.3
  • 31
    • 84873085581 scopus 로고    scopus 로고
    • Long-term efficacy and safety comparison of liraglutide, glimepiride and placebo, all in combination with metformin in type 2 diabetes: 2-year results from the LEAD-2 study
    • Nauck M, Frid A, Hermansen K, et al. Long-term efficacy and safety comparison of liraglutide, glimepiride and placebo, all in combination with metformin in type 2 diabetes: 2-year results from the LEAD-2 study. Diabetes Obes Metab. 2013;15 (3):204-212.
    • (2013) Diabetes Obes Metab , vol.15 , Issue.3 , pp. 204-212
    • Nauck, M.1    Frid, A.2    Hermansen, K.3
  • 32
    • 0037237279 scopus 로고    scopus 로고
    • The forkhead transcription factor FoxO1 regulates adipocyte differentiation
    • Nakae J, Kitamura T, Kitamura Y, Biggs WH 3rd, Arden KC, Accili D. The forkhead transcription factor FoxO1 regulates adipocyte differentiation. Dev Cell. 2003;4 (1):119-129.
    • (2003) Dev Cell , vol.4 , Issue.1 , pp. 119-129
    • Nakae, J.1    Kitamura, T.2    Kitamura, Y.3    Biggs, W.H.4    Arden, K.C.5    Accili, D.6
  • 33
    • 65349177200 scopus 로고    scopus 로고
    • AMPK: An emerging drug target for diabetes and the metabolic syndrome
    • Zhang BB, Zhou G, Li C. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab. 2009;9 (5):407-416.
    • (2009) Cell Metab , vol.9 , Issue.5 , pp. 407-416
    • Zhang, B.B.1    Zhou, G.2    Li, C.3
  • 34
    • 40549135297 scopus 로고    scopus 로고
    • Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: Lessons from genetically engineered mice
    • Postic C, Girard J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest. 2008;118 (3):829-838.
    • (2008) J Clin Invest , vol.118 , Issue.3 , pp. 829-838
    • Postic, C.1    Girard, J.2
  • 35
    • 77950192925 scopus 로고    scopus 로고
    • Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: Role of ATGL, HSL, and AMPK
    • Gaidhu MP, Anthony NM, Patel P, Hawke TJ, Ceddia RB. Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK. Am J Physiol Cell Physiol. 2010;298 (4):C961-C971.
    • (2010) Am J Physiol Cell Physiol , vol.298 , Issue.4 , pp. C961-C971
    • Gaidhu, M.P.1    Anthony, N.M.2    Patel, P.3    Hawke, T.J.4    Ceddia, R.B.5
  • 37
    • 78650964142 scopus 로고    scopus 로고
    • Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans
    • Gauthier MS, O’Brien EL, Bigornia S, et al. Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem Biophys Res Commun. 2011;404 (1):382-387.
    • (2011) Biochem Biophys Res Commun , vol.404 , Issue.1 , pp. 382-387
    • Gauthier, M.S.1    O’Brien, E.L.2    Bigornia, S.3
  • 38
    • 34147152841 scopus 로고    scopus 로고
    • Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
    • Sanders MJ, Grondin PO, Hegarty BD, Snowden MA, Carling D. Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem J. 2007;403 (1):139-148.
    • (2007) Biochem J , vol.403 , Issue.1 , pp. 139-148
    • Sanders, M.J.1    Grondin, P.O.2    Hegarty, B.D.3    Snowden, M.A.4    Carling, D.5
  • 39
    • 80053156616 scopus 로고    scopus 로고
    • The Ca2+/calmodulin-dependent protein kinase kinase, CaMKK2, inhibits preadipocyte differentiation
    • Lin F, Ribar TJ, Means AR. The Ca2+/calmodulin-dependent protein kinase kinase, CaMKK2, inhibits preadipocyte differentiation. Endocrinology. 2011;152 (10):3668-3679.
    • (2011) Endocrinology , vol.152 , Issue.10 , pp. 3668-3679
    • Lin, F.1    Ribar, T.J.2    Means, A.R.3
  • 40
    • 77953724336 scopus 로고    scopus 로고
    • Role of the glucagon-like-peptide-1 receptor in the control of energy balance
    • Hayes MR, De Jonghe BC, Kanoski SE. Role of the glucagon-like-peptide-1 receptor in the control of energy balance. Physiol Behav. 2010;100 (5):503-510.
    • (2010) Physiol Behav , vol.100 , Issue.5 , pp. 503-510
    • Hayes, M.R.1    De Jonghe, B.C.2    Kanoski, S.E.3
  • 41
    • 65949097938 scopus 로고    scopus 로고
    • Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity
    • Nogueiras R, Pérez-Tilve D, Veyrat-Durebex C, et al. Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. J Neurosci. 2009;29 (18):5916-5925.
    • (2009) J Neurosci , vol.29 , Issue.18 , pp. 5916-5925
    • Nogueiras, R.1    Pérez-Tilve, D.2    Veyrat-Durebex, C.3
  • 42
    • 0037031840 scopus 로고    scopus 로고
    • Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise
    • Park H, Kaushik VK, Constant S, et al. Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. J Biol Chem. 2002;277 (36):32571-32577.
    • (2002) J Biol Chem , vol.277 , Issue.36 , pp. 32571-32577
    • Park, H.1    Kaushik, V.K.2    Constant, S.3
  • 43
    • 65949116390 scopus 로고    scopus 로고
    • Adiponectin-activated AMPK stimulates dephosphorylation of AKT through protein phosphatase 2A activation
    • Kim KY, Baek A, Hwang JE, et al. Adiponectin-activated AMPK stimulates dephosphorylation of AKT through protein phosphatase 2A activation. Cancer Res. 2009;69 (9):4018-4026.
    • (2009) Cancer Res , vol.69 , Issue.9 , pp. 4018-4026
    • Kim, K.Y.1    Baek, A.2    Hwang, J.E.3


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