Leukotriene B4 activates intracellular calcium and augments human osteoclastogenesis

Arthritis Research and Therapy

Volumn 16, Issue 1, 2014, Pages

  Dixit, Neha ^a   Wu, Dennis J ^a   Belgacem, Yesser H ^b   Borodinsky, Laura N ^b   Gershwin, M Eric ^a   Adamopoulos, Iannis E ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SHRINERS HOSPITALS FOR CHILDREN NORTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ARACHIDONATE 5 LIPOXYGENASE; BETA3 INTEGRIN; CALCIUM; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL; CATHEPSIN K; COLONY STIMULATING FACTOR 1; F ACTIN; GELATINASE B; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 23 RECEPTOR; LEUKOTRIENE A4 HYDROLASE; LEUKOTRIENE B4; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHOLIPASE A2; PHOSPHOLIPASE C; TRANSCRIPTION FACTOR NFAT; WORTMANNIN;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CELL LINEAGE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EXTRACELLULAR CALCIUM; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; INNATE IMMUNITY; MACROPHAGE; OSTEOCLAST; OSTEOCLASTOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; UPREGULATION; INTRACELLULAR FLUID; METABOLISM; MONONUCLEAR CELL; PHYSIOLOGY;

CALCIUM; CALCIUM SIGNALING; CELL DIFFERENTIATION; HUMANS; INTRACELLULAR FLUID; LEUKOCYTES, MONONUCLEAR; LEUKOTRIENE B4; OSTEOCLASTS;

EID: 84923194602     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/s13075-014-0496-y     Document Type: Article

References (45)

1. Arai F, Miyamoto T, Ohneda O, Inada T, Sudo T, Brasel K, Miyata T, Anderson DM, Suda T: Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor κB (RANK) receptors. J Exp Med 1999, 190:1741-1754.
2. Takeshita S, Kaji K, Kudo A: Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts. J Bone Miner Res 2000, 15:1477-1488.
3. Zhang YH, Heulsmann A, Tondravi MM, Mukherjee A, Abu-Amer Y: Tumor necrosis factor-α (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways. J Biol Chem 2001, 276:563-568.
4. Kotake S, Udagawa N, Takahashi N, Matsuzaki K, Itoh K, Ishiyama S, Saito S, Inoue K, Kamatani N, Gillespie MT, Martin TJ, Suda T: IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 1999, 103:1345-1352.
5. Adamopoulos IE, Tessmer M, Chao CC, Adda S, Gorman D, Petro M, Chou CC, Pierce RH, Yao W, Lane NE, Laface D, Bowman EP: IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone mass. J Immunol 2011, 187:951-959.
6. Sato K, Suematsu A, Okamoto K, Yamaguchi A, Morishita Y, Kadono Y, Tanaka S, Kodama T, Akira S, Iwakura Y, Cua DJ, Takayanagi H: Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med 2006, 203:2673-2682.
7. Hein P, Frank M, Hoffmann C, Lohse MJ, Bünemann M: Dynamics of receptor/G protein coupling in living cells. EMBO J 2005, 24:4106-4114.
8. Hur EM, Kim KT: G protein-coupled receptor signalling and cross-talk: achieving rapidity and specificity. Cell Signal 2002, 14:397-405.
9. Hikiji H, Ishii S, Yokomizo T, Takato T, Shimizu T: A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss. Proc Natl Acad Sci U S A 2009, 106:21294-21299.
10. Samuelsson B: An elucidation of the arachidonic acid cascade: discovery of prostaglandins, thromboxane and leukotrienes. Drugs 1987, 33:2-9.
11. 2 . J Biol Chem 1997, 272:16709-16712.
12. Mandal AK, Jones PB, Bair AM, Christmas P, Miller D, Yamin TT, Wisniewski D, Menke J, Evans JF, Hyman BT, Bacskai B, Chen M, Lee DM, Nikolic B, Soberman RJ: The nuclear membrane organization of leukotriene synthesis. Proc Natl Acad Sci U S A 2008, 105:20434-20439.
13. Mathis S, Jala VR, Haribabu B: Role of leukotriene B4 receptors in rheumatoid arthritis. Autoimmun Rev 2007, 7:12-17.
14. Yokomizo T: Leukotriene B4 receptors: novel roles in immunological regulations. Adv Enzym Regul 2011, 51:59-64.
15. Mathis SP, Jala VR, Lee DM, Haribabu B: Nonredundant roles for leukotriene B4 receptors BLT1 and BLT2 in inflammatory arthritis. J Immunol 2010, 185:3049-3056.
16. Lee JM, Park H, Noh AL, Kang JH, Chen L, Zheng T, Lee J, Ji SY, Jang CY, Shin CS, Ha H, Lee ZH, Park HY, Lee DS, Yim M: 5-Lipoxygenase mediates RANKL-induced osteoclast formation via the cysteinyl leukotriene receptor 1. J Immunol 2012, 189:5284-5292.
17. Chen M, Lam BK, Kanaoka Y, Nigrovic PA, Audoly LP, Austen KF, Lee DM: Neutrophil-derived leukotriene B4 is required for inflammatory arthritis. J Exp Med 2006, 203:837-842.
18. Iversen L, Kragballe K, Ziboh VA: Significance of leukotriene-A4 hydrolase in the pathogenesis of psoriasis. Skin Pharmacol 1997, 10:169-177.
19. Csoma Z, Kharitonov SA, Balint B, Bush A, Wilson NM, Barnes PJ: Increased leukotrienes in exhaled breath condensate in childhood asthma. Am J Respir Crit Care Med 2002, 166:1345-1349.
20. Adamopoulos IE, Sabokbar A, Wordsworth BP, Carr A, Ferguson DJ, Athanasou NA: Synovial fluid macrophages are capable of osteoclast formation and resorption. J Pathol 2006, 208:35-43.
21. Lin AH, Morris J, Wishka DG, Gorman RR: Novel molecules that antagonize leukotriene B4 binding to neutrophils. Ann N Y Acad Sci 1988, 524:196-200.
22. Silbaugh SA, Stengel PW, Cockerham SL, Roman CR, Saussy DL Jr, Spaethe SM, Goodson T Jr, Herron DK, Fleisch JH: Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist. Eur J Pharmacol 1992, 223:57-64.
23. Shugg RP, Thomson A, Tanabe N, Kashishian A, Steiner BH, Puri KD, Pereverzev A, Lannutti BJ, Jirik FR, Dixon SJ, Sims SM: Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption. J Biol Chem 2013, 288:35346-35357.
24. 3 integrin- and macrophage colony stimulating factor-mediated signals on phospholipase Cγ in prefusion osteoclasts. J Cell Biol 2001, 152:361-373.
25. Mentaverri R, Kamel S, Brazier M: Involvement of capacitive calcium entry and calcium store refilling in osteoclastic survival and bone resorption process. Cell Calcium 2003, 34:169-175.
26. Shahrara S, Huang Q, Mandelin AM 2nd, Pope RM: TH-17 cells in rheumatoid arthritis. Arthritis Res Ther 2008, 10:R93.
27. Zhou Y, Lewis TL, Robinson LJ, Brundage KM, Schafer R, Martin KH, Blair HC, Soboloff J, Barnett JB: The role of calcium release activated calcium channels in osteoclast differentiation. J Cell Physiol 2011, 226:1082-1089.
28. Kajiya H: Calcium signaling in osteoclast differentiation and bone resorption. Adv Exp Med Biol 2012, 740:917-932.
29. Floss DM, Mrotzek S, Klöcker T, Schröder J, Grötzinger J, Rose-John S, Scheller J: Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor. J Biol Chem 2013, 288:19386-19400.
30. Myou S, Leff AR, Myo S, Boetticher E, Meliton AY, Lambertino AT, Liu J, Xu C, Munoz NM, Zhu X: Activation of group IV cytosolic phospholipase A2 in human eosinophils by phosphoinositide 3-kinase through a mitogen-activated protein kinase-independent pathway. J Immunol 2003, 171:4399-4405.
31. 4 stimulates osteoclastic bone resorption both in vitro and in vivo. J Bone Miner Res 1996, 11:1619-1627.
32. Sadik CD, Kim ND, Iwakura Y, Luster AD: Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling. Proc Natl Acad Sci U S A 2012, 109:E3177-E3185.
33. Monach PA, Nigrovic PA, Chen M, Hock H, Lee DM, Benoist C, Mathis D: Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor γ, the receptor for C5a, and lymphocyte function-associated antigen 1. Arthritis Rheum 2010, 62:753-764.
34. + T cells is required for their migration into tumors to elicit effective antitumor immunity. J Immunol 2013, 191:3462-3470.
35. Matsunaga Y, Fukuyama S, Okuno T, Sasaki F, Matsunobu T, Asai Y, Matsumoto K, Saeki K, Oike M, Sadamura Y, Machida K, Nakanishi Y, Kubo M, Yokomizo T, Inoue H: Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia. FASEB J 2013, 27:3306-3314.
36. 2 by TNF-α mediated through Nox2, MAPKs, NF-κB, and p300 in human tracheal smooth muscle cells. J Cell Physiol 2011, 226:2103-2114.
37. 2 expression in human lung epithelial cells via JNK1/2- and p38 MAPK-dependent AP-1 activation. PLoS One 2013, 8:e72783. A published erratum appears in PLoS One 2013, 8(12). doi:10.1371/annotation/f56711b9-78f1-49ed-9116-872913e98867.
38. Yago T, Nanke Y, Kawamoto M, Furuya T, Kobashigawa T, Kamatani N, Kotake S: IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. Arthritis Res Ther 2007, 9:R96.
39. Garg HG, Hales CA (Eds): Chemistry and Biology of Hyaluronan. Oxford, UK: Elsevier. 2004.
40. Yago T, Nanke Y, Ichikawa N, Kobashigawa T, Mogi M, Kamatani N, Kotake S: IL-17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti-TNF-α antibody: a novel mechanism of osteoclastogenesis by IL-17. J Cell Biochem 2009, 108:947-955.
41. Hogan PG, Chen L, Nardone J, Rao A: Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 2003, 17:2205-2232.
42. 2+ release. FASEB J 2002, 16:1145-1150.
43. 3 receptors. J Physiol 2001, 536:3-19.
44. Hwang SY, Putney JW: Orai1-mediated calcium entry plays a critical role in osteoclast differentiation and function by regulating activation of the transcription factor NFATc1. FASEB J 2012, 26:1484-1492.
45. Ong EC, Nesin V, Long CL, Bai CX, Guz JL, Ivanov IP, Abramowitz J, Birnbaumer L, Humphrey MB, Tsiokas L: A TRPC1 protein-dependent pathway regulates osteoclast formation and function. J Biol Chem 2013, 288:22219-22232.