The nuclear membrane organization of leukotriene synthesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 51, 2008, Pages 20434-20439

  Mandal, Asim K ^a   Jones, Phillip B ^a   Bair, Angela M ^a   Christmas, Peter ^a   Miller, Douglas ^b   Yamin, Ting Ting D ^b   Wisniewski, Douglas ^b   Menke, John ^b   Evans, Jilly F ^b   Hyman, Bradley T ^a   Bacskai, Brian ^a   Chen, Mei ^c   Lee, David M ^c   Nikolic, Boris ^a   Soberman, Roy J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

5 lipoxygenase; 5 lipoxygenase activating protein; Inflammation; Multiprotein complex

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; LEUKOTRIENE; SCAFFOLD PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL ISOLATION; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; MEMBRANE STRUCTURE; MOLECULE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN SYNTHESIS;

ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; ARTHRITIS; CARRIER PROTEINS; LEUKOTRIENES; MEMBRANE PROTEINS; MICE; MULTIPROTEIN COMPLEXES; MYELOID CELLS; NEUTROPHILS; NUCLEAR ENVELOPE;

EID: 58149511977     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0808211106     Document Type: Article

References (32)

1. Ford-Hutchinson AW, Bray MA, Doig MV, Shipley NE, Smith MJH (1980) Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286:264-265.
2. 4. Nat Immunol 4:974-981.
3. 4 receptor BLT1 mediates early effector T cell recruitment. Nat Immunol 4:982-990.
4. 2 from cytosol to the nuclear envelope in rat basophilic leukemia cells activated with calcium ionophore or IgE/antigen. J Biol Chem 270:15399-153407.
5. 2 translocation to internal membranes. J Biol Chem 276:30150-30160.
6. Brock TG, McNish RW, Bailie MW, Peters-Golden M (1997) Rapid import of cytosolic 5-lipoxygenase into the nucleus of PMNs after in vivo recruitment and in vitro adherence. J Biol Chem 272:8276-8280.
7. Miller DK, et al. (1990) Identification and isolation of a membrane protein necessary for leukotriene production. Nature 343:278-281.
8. Dixon RAF, et al. (1990) Requirement of a 5-lipoxygenase- activating protein for leukotriene synthesis. Nature 343:282-284.
9. Woods J, et al. (1993) 5-lipoxygenase and 5-lipoxygenase- activating protein are localized in the nuclear envelope of activated human leukocytes. J Exp Med 178:1935-1946.
10. 4 synthase. J Biol Chem 277:28902-28908.
11. Wong W, Scott JD (2004) AKAP signalling complexes: Focal points in space and time. Nat Rev Mol Cell Biol 5:959-970.
12. Okamoto T, Amnon S, Scherer PE, Lisanti MP (1998) Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J Biol Chem 273:5419-5422.
13. 4 synthesis. J Immunol 140:4315-4322.
14. 4 in response to soluble agonists. J Immunol 147:3855-3861.
15. 4 in chemotactic peptide-stimulated human neutrophils. FASEB J 12:1521-1531.
16. Ferguson AD, et al. (2007) Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein. Science 317:510-512.
17. Yamashita M, et al. (2000) Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells. Br J Pharmacol 129:367-373.
18. Fleming TJ, et al. (1997) Negative regulation of FcεR1-mediated degranualtion by CD81. J Exp Med 186:1307-1314.
19. Mandal AK, et al. (2004) The membrane organization of leukotriene synthesis. Proc Natl Acad Sci USA 101:6587-6592.
20. 4 is required for inflammatory arthritis. J Exp Med 203:837-842.
21. Nigrovic PA, et al. Mast cells contribute to initiation of auto antibody-mediated arthritis via IL-1. Proc Natl Acad Sci USA 104:2325-2330.
22. Jones PB, et al. (2008) Two post-processing techniques for the elimination of background autofluorescence for FLIM. J. Biomed Optics 13:-14008-8.
23. Mancini JA, et al. (1993) 5-lipoxygenase-activating protein is an arachidonic acid binding protein. FEBS Lett 318:277-281.
24. Ago H, et al. (2007) Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. Nature 448:609-612.
25. 4 synthase. Nature 448:613-616.
26. Sieber JJ, et al. (2007) Anatomy and dynamics of a supramolecular membrane protein cluster. Science 317:1072-1076.
27. 4 synthetic capacity. Proc Natl Acad Sci USA 100:12165-12170.
28. Tschopp J, Martinon F, Burn K (2003) Nalp3's: A novel protein family involved in inflammation. Nat Rev Mol Cell Biol 4:95-104.
29. Kinoshita A, et al. (2003) Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes. J Cell Sci 116:3339-3346.
30. Lennon NJ, et al. (2001) Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. J Biol Chem 278:50466-50473.
31. 4. Anal Biochem 349:129-135.
32. 4. J Biol Chem 281:7189-7196.