Synovial fluid macrophages are capable of osteoclast formation and resorption

Journal of Pathology

Volumn 208, Issue 1, 2006, Pages 35-43

  Adamopoulos, I E ^a   Sabokbar, A ^b   Wordsworth, B P ^c   Carr, A ^c   Ferguson, D J ^d   Athanasou, Nick A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Macrophages; Osteoarthritis; Osteoclasts; Pyrophosphate; Rheumatoid arthritis; Synovial fluid

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; COLONY STIMULATING FACTOR 1; F ACTIN; HUMORAL ANTIBODY; INTERLEUKIN 1ALPHA; OSTEOCLAST DIFFERENTIATION FACTOR; PYROPHOSPHATE; TUMOR NECROSIS FACTOR ALPHA; VITRONECTIN RECEPTOR;

ADULT; AGED; ARTHROPATHY; ARTICLE; BONE EROSION; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CELL MATURATION; CLINICAL ARTICLE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MACROPHAGE; MALE; OSTEOARTHRITIS; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID;

AGED; ANTIGENS, CD14; ARTHRITIS, RHEUMATOID; BONE RESORPTION; CARRIER PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; CHONDROCALCINOSIS; FEMALE; HUMANS; INTERLEUKIN-1; KNEE JOINT; MACROPHAGES; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; OSTEOARTHRITIS, KNEE; OSTEOCLASTS; OSTEOGENESIS; PHENOTYPE; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; SYNOVIAL FLUID; TUMOR NECROSIS FACTOR-ALPHA;

EID: 29844442075     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1891     Document Type: Article

References (49)

1. Freemont A, Denton J. Atlas of Synovial Fluid Cytopathology. Dordrecht, 1991.
2. Athanasou NA. Cellular biology of bone-resorbing cells. Am J Bone Joint Surg 1996;78(7):1096-1112.
3. Fujikawa Y, Quinn JM, Sabokbar A, McGee JO, Athanasou NA. The human osteoclast precursor circulates in the monocyte fraction. Endocrinology 1996;137(9):4058-4060.
4. Danks L, Sabokbar A, Gundle R, Athanasou NA. Synovial macrophage-osteoclast differentiation in inflammatory arthritis. Ann Rheum Dis 2002;61(10):916-921.
5. Fujikawa Y, Sabokbar A, Neale S, Athanasou NA. Human osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis. Ann Rheum Dis 1996;55(11):816-822.
6. Itonaga I, Fujikawa Y, Sabokbar A, Murray DW, Athanasou NA. Rheumatoid arthritis synovial macrophage-osteoclast differentiation is osteoprotegerin ligand-dependent. J Pathol 2000;192(1):97-104.
7. Udagawa N, Kotake S, Kamatani N, Takahashi N, Suda T. The molecular mechanism of osteoclastogenesis in rheumatoid arthritis. Arthritis Res 2002;4(5):281-289.
8. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997;89(2):309-319.
9. Hofbauer LC, Gori F, Riggs BL, Lacey DL, Dunstan CR, Spelsberg TC, et al. Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis. Endocrinology 1999;140(10):4382-4389.
10. Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Spelsberg TC, Riggs BL. Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells. Endocrinology 1999;140(9):4367-4370.
11. Kotake S, Udagawa N, Hakoda M, Mogi M, Yano K, Tsuda E, et al. Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients. Arthritis Rheum 2001;44(5):1003-1012.
12. Feuerherm AJ, Borset M, Seidel C, Sundan A, Leistad L, Ostensen M, et al. Elevated levels of osteoprotegerin (OPG) and hepatocyte growth factor (HGF) in rheumatoid arthritis. Scand J Rheumatol 2001;30(4):229-234.
13. Kudo O, Fujikawa Y, Itonaga I, Sabokbar A, Torisu T, Athanasou NA. Proinflammatory cytokine (TNFα/IL-1α) induction of human osteoclast formation. J Pathol 2002;198(2):220-227.
14. Pfeilschifter J, Chenu C, Bird A, Mundy GR, Roodman GD. Interleukin-I and tumor necrosis factor stimulate the formation of human osteoclastlike cells in vitro. J Bone Miner Res 1989;4(1):113-118.
15. Minkin C. Bone acid phosphatase: tartrate-resistant acid phosphatase as a marker of osteoclast function. Calcif Tissue Int 1982;34(3):285-290.
16. Davies J, Warwick J, Totty N, Philp R, Helfrich M, Horton M. The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. J Cell Biol 1989;109(4,1):1817-1826.
17. Athanasou NA, Quinn J. Immunophenotypic differences between osteoclasts and macrophage polykaryons: immunohistological distinction and implications for osteoclast ontogeny and function. J Clin Pathol 1990;43(12):997-1003.
18. Braet F, De Zanger R, Wisse E. Drying cells for SEM, AFM and TEM by hexamethyldisilazane: a study on hepatic endothelial cells. J Microsc 1997;186(1):84-87.
19. Sato M, Grasser W. Effects of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopy. J Bone Miner Res 1990;5(1):31-40.
20. Hattersley G, Chambers TJ. Calcitonin receptors as markers for osteoclastic differentiation: correlation between generation of bone-resorptive cells and cells that express calcitonin receptors in mouse bone marrow cultures. Endocrinology 1989;125(3):1606-1612.
21. Lakkakorpi P, Tuukkanen J, Hentunen T, Jarvelin K, Vaananen K. Organization of osteoclast microtilaments during the attachment to bone surface in vitro. J Bone Miner Res 1989;4(6):817-825.
22. Aubin JE. Osteoclast adhesion and resorption: the role of podosomes. J Bone Miner Res 1992;7(4):365 -368.
23. Zambonin-Zallone A, Teti A, Grano M, Rubinacci A, Abbadini M, Gaboli M, et al. Immunocytochemical distribution of extracellular matrix receptors in human osteoclasts: a β3 integrin is co-localized with vinculin and talin in the podosomes of osteoclastoma giant cells. Exp Cell Res 1989;182(2):645-652.
24. Nesbitt SA, Horton MA. Trafficking of matrix collagens through bone-resorbing osteoclasts. Science 1997;276(5310):266-269.
25. Neidhart M, Seemayer CA, Hummel KM, Michel BA, Gay RE, Gay S. Functional characterization of adherent synovial fluid cells in rheumatoid arthritis: destructive potential in vitro and in vivo. Arthritis Rheum 2003;48(7):1873-1880.
26. Takano H, Tomita T, Toyosaki-Maeda T, Maeda-Tanimura M, Tsuboi H, Takeuchi E, et al. Comparison of the activities of multinucleated bone-resorbing giant cells derived from CD14-positive cells in the synovial fluids of rheumatoid arthritis and osteoarthritis patients. Rheumatology 2004;43(4):435-441.
27. Li J, Sarosi I, Yan X-Q, Morony S, Capparelli C, Tan H-L, et al. RANK is the intrinsic hernatopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci USA 2000;97(4):1566-1571.
28. Azuma Y, Kaji K, Katogi R, Takeshita S, Kudo A. Tumor necrosis factor-alpha induces differentiation of and bone resorption by osteoclasts. J Biol Chem 2000;275(7):4858-4864.
29. Partsch G, Wagner E, Leeb BF, Dunky A, Steiner G, Smolen JS. Up-regulation of cytokine receptors sTNF-R55, sTNF-R75, and sIL-2R in psoriatic arthritis synovial fluid. J Rheumatol 1998;25(1):105-110.
30. Kohno T, Brewer MT, Baker SL, Schwartz PE, King MW, Hale KK, et al. A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor. Proc Natl Acad Sci USA 1990;87(21):8331-8335.
31. Kawaji H, Yokomura K, Kikuchi K, Sornoto Y, Shirai Y. [Macrophage colony-stimulating factor in patients with rheumatoid arthritis]. Nippon Ika Daigaku Zasshi 1995;62(3):260-270 [in Japanese].
32. Kotake S, Udagawa N, Takahashi N, Matsuzaki K, Itoh K, Ishiyama S, et al. IL- 17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 1999;103(9):1345-1352.
33. Tokayer A, Carsons SE, Chokshi B, Santiago-Schwarz F. High levels of interleukin 13 in rheumatoid arthritis sera are modulated by tumor necrosis factor antagonist therapy: association with dendritic cell growth activity. J Rheumatol 2002;29(3):454-461.
34. Partsch G, Steiner G, Leeb BF, Dunky A, Broll H, Smolen JS. Highly increased levels of tumor necrosis factor-alpha and other proinflammatory cytokines in psoriatic arthritis synovial fluid. J Rheumatol 1997;24(3):518-523.
35. Yukioka K, Inaba M, Furumitsu Y, Yukioka M, Nishino T, Goto H, et al. Levels of hepatocyte growth factor in synovial fluid and serum of patients with rheumatoid arthritis and release of hepatocyte growth factor by rheumatoid synovial fluid cells. J Rheumatol 1994;21(12):2184-2189.
36. Guerne PA, Terkeltaub R, Zuraw B, Lotz M. Inflammatory microcrystals stimulate interleukin-6 production and secretion by human monocytes and synoviocytes. Arthritis Rheum 1989;32(11):1443-1452.
37. Liu R, O'Connell M, Johnson K, Pritzker K, Mackman N, Terkeltaub R. Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein I and nuclear factor-kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells. Arthritis Rheum 2000;43(5):1145-1155.
38. Meng ZH, Hudson AP, Schumacher HR Jr, Baker JF, Baker DG. Monosodium. urate, hydroxyapatite, and calcium pyrophosphate crystals induce tumor necrosis factor-alpha expression in a mononuclear cell line. J Rheumatol 1997;24(12):2385-2388.
39. Watanabe W, Baker DG, Schumacher HR Jr. Comparison of the acute inflammation induced by calcium pyrophosphate dihydrate, apatite and mixed crystals in the rat air pouch model of a synovial space. J Rheumatol 1992;19(9):1453-1457.
40. Hamilton JA, McCarthy G, Whitty G. Inflammatory microcrystals induce munne macrophage survival and DNA synthesis. Arthritis Res 2001;3(4):242-246.
41. Hamilton JA. Nondisposable materials, chronic inflammation, and adjuvant action. J Leukoc Biol 2003;73(6):702-712.
42. Sterling H, Saginario C, Vignery A. CD44 occupancy prevents macrophage multinucleation. J Cell Biol 1998;143(3):837-847.
43. Quinn JM, Whitty GA, Byrne RJ, Gillespie MT, Hamilton JA. The generation of highly enriched osteoclast-lineage cell populations. Bone 2002;30(1):164-170.
44. Humphrey MB, Ogasawara K, Yao W, Spusta SC, Daws MR, Lane NE, et al. The signaling adapter protein DAP12 regulates multinucleation during osteoclast development. J Bone Miner Res 2004;19(2):224-234.
45. Kania JR, Kehat-Stadler T, Kupfer SR. CD44 antibodies inhibit osteoclast formation. J Bone Miner Res 1997;12(8):1155-1164.
46. Demaziere A, Athanasou NA. Adhesion receptors of intimal and subintimal cells of the normal synovial membrane. J Pathol 1992;168(2):209-215.
47. Vignery A. Osteoclasts and giant cells: macrophage-macrophage fusion mechanism. Int J Exp Pathol 2000;81(5):291-304.
48. Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B. CD44 is the principal cell surface receptor for hyaluronate. Cell 1990;61(7):1303-1313.
49. Haynes BF, Hale LP, Patton KL, Martin ME, McCallum RM. Measurement of an adhesion molecule as an indicator of inflammatory disease activity. Up-regulation of the receptor for hyaluronate (CD44) in rheumatoid arthritis. Arthritis Rheum 1991;34(11):1434-1443.