Leukotriene B4 stimulates osteoclastic bone resorption both in vitro and in vivo

Journal of Bone and Mineral Research

Volumn 11, Issue 11, 1996, Pages 1619-1627

  Garcia, Carlos ^a   Boyce, Brendan F ^a   Gilles, James ^a   Dallas, Mark ^a   Qiao, Mei ^a   Mundy, Gregory R ^a   Bonewald, Lynda F ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYICOSATETRAENOIC ACID; LEUKOTRIENE B4; LEUKOTRIENE C4; LEUKOTRIENE D4; LEUKOTRIENE E4; CALCITRIOL; LEUKOTRIENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; CALVARIA; CONTROLLED STUDY; MOUSE; NEWBORN; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; ANALYSIS OF VARIANCE; ANIMAL; BONE MARROW; BONE MARROW CELL; CELL CULTURE; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DRUG EFFECT; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; ORGAN CULTURE TECHNIQUE; PATHOLOGY; RAT; SIGNAL TRANSDUCTION; STIMULATION;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BONE MARROW; BONE MARROW CELLS; BONE RESORPTION; CALCITRIOL; CELLS, CULTURED; HUMANS; LEUKOTRIENE B4; LEUKOTRIENES; MICE; MICE, INBRED ICR; ORGAN CULTURE TECHNIQUES; OSTEOCLASTS; RATS; SIGNAL TRANSDUCTION; STIMULATION, CHEMICAL;

EID: 0029657888     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.5650111105     Document Type: Article

References (38)

1. Klein DC, Raisz LG 1970 Prostaglandins: Stimulation of bone resorption in tissue culture. Endocrinology 86:1436-1440.
2. Arnett TR, Dempster DW 1987 A comparative study of disaggregated chick and rat osteoclasts in vitro: Effect of calcitonin and prostaglandins. Endocrinology 120:602-608.
3. Fuller K, Chambers TJ 1989 Effect of arachidonic acid metabolites on bone resorption by isolated rat osteoclasts. J Bone Miner Res 4:209-215.
4. Chambers TJ, McSheehy PMJ, Thomason BM, Fuller K 1985 The effect of calcium-regulating hormones and prostaglandins on bone resorption by osteoclasts disaggregated from neonatal rabbit bones. Endocrinology 60:234-239.
5. de Vernejoul M-C, Horowitz M, Demignon J, Neff L, Baron R 1988 Bone resorption by isolated chick osteoclasts in culture is stimulated by murine spleen cell supernatant fluids (osteoclast-activating factor) and inhibited by calcitonin and prostaglandin E2. J Bone Miner Res 3:69-80.
6. Meghji S, Sandy JR, Scuff AM, Harvey W, Harris M 1988 Stimulation of bone resorption by lipoxygenase metabolites of arachidonic acid. Prostaglandins 36:139-149.
7. Gallwitz WE, Mundy GR, Lee CH, Qiao M, Roodman GD, Raftery M, Gaskell J, Bonewald LF 1993 5-lipoxygenase metabolites of arachidonic acid stimulate isolated osteoclasts to resorb calcified matrices. J Biol Chem 268:10087-10094.
8. Garcia C, Qiao M, Kirchen M, Gallwitz W, Mundy GR, Bonewald LF 1996 Effects of synthetic peptido-leukotrienes on bone resorption in vitro. J Bone Miner Res 11:521-529.
9. Keppler D 1992 Leukotrienes: Biosynthesis, transport, inactivation and analysis. Rev Phys Biochem Pharmacol 121:2-23.
10. Boyce BF, Aufdemorte TB, Garrett IR, Yates AJP, Mundy GR 1989 Effects of interleukin-1 on bone turnover in normal mice. Endocrinology 125:1142-1150.
11. Gowen M, Wood OD, Ihrie EJ, McGuire MKB, Russell RGG 1983 An interleukin-1-like factor stimulates bone resorption in vivo. Nature 306:378-380.
12. Oreffo ROC, Marshall GJ, Kirchen M, Gallwitz WE, Chavez J, Mundy GR, Bonewald LF 1993 Characterization of a cell line derived from a human giant cell tumor which stimulates osteoclastic bone resorption. Clin Orthop 296:229-241.
13. Arnett TR, Dempster DW 1990 Perspectives: Protons and osteoclasts. J Bone Miner Res 5:1099-1103.
14. MacDonald BR, Mundy GR, Clark S, Wang EA, Keuhl TJ, Stanley ER, Roodman GD 1986 Effects of human recombinant CSF-GM and highly purified CSF-1 on the formation of multinucleated cells with osteoclast characteristics in long-term bone marrow cultures. J Bone Miner Res 1:227-233.
15. Takahashi N, Yamana H, Yoshiki S, Roodman GD, Mundy GR, Jones SJ, Boyce A, Suda T 1988 Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology 122:1373-1382.
16. Sigal E 1991 The molecular biology of mammalian arachidonic acid metabolism. Am J Physiol 260:L13-L98.
17. Smith WL 1992 Prostanoid biosynthesis and mechanisms of action. Am J Physiol 263:F181-F191.
18. Raisz LG, Martin TJ 1984 Prostaglandins in bone and mineral metabolism. In: Peck WA (ed.) Bone and Mineral Research, 2nd annual edition. Elsevier, Amsterdam, The Netherlands, pp. 286-310.
19. Ito H, Ke HZ, Jee WS, Sakou T 1993 Anabolic responses of an adult cancellous bone site to prostaglandin E2 in the rat. Bone Miner 21:219-236.
20. Ren W, Dziak R 1991 Effects of leukotrienes on osteoblastic cell proliferation. Calcif Tissue Int 49:197-201.
21. 4 increases intracellular calcium concentration and phosphoinositide metabolism in mouse osteoblasts via cyclic adenosine 3́,5́-monophosphate-independent pathways. Endocrinology 129:582-590.
22. 4 to receptors on human polymorphonuclear leukocytes. J Immunol 129:1600-1604.
23. 4 on the chemotactic and metabolic response of human neutrophils. Anal Biochem 161:550-558.
24. 4 receptor. J Biol Chem 268:9280-9286.
25. 4. J Biol Chem 257:4680-4683.
26. 4 and inflammatory disease. Agents Actions 24:114-119.
27. Henderson B, Higgs GA 1987 Synthesis of arachidonate oxidation products by synovial joint tissues during the development of chronic erosive arthritis. Arthritis Rheum 30:1149-1156.
28. 4 by neutrophils in rheumatoid arthritis. Ann Rheum Dis 46:501-505.
29. Klickstein LB, Shapleigh C, Goetzl EJ 1980 Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondylarthritis. J Clin Invest 66:1166-1170.
30. 4, an inflammatory mediator in gout. Lancet ii:112-114.
31. 4, a mediator of inflammation present in synovial fluid, in rheumatoid arthritis. Ann Rheum Dis 42:677-679.
32. Bajpai P, Bajpai PK 1992 Arachidonic acid production by microorganisms. Biotechnol Appl Biochem 15:1-1.
33. 4. Brit J Pharmacol 107:226-232.
34. Keppler D, Muller M, Klunemann C, Guhlmann A, Krauss K, Muller J, Berger U, Leier I, Mayatepek E 1992 Transport and in vivo elimination of cysteinyl leukotrienes. Adv Enzyme Reg 32:107-116.
35. Denzlinger C, Guhlmann A, Scheuber PJ, Wilker D, Hammer DK, Keppler D 1986 Metabolism and analysis of cysteinyl leukotrienes in the monkey. J Biol Chem 261:15601-15606.
36. Piper PJ, Controy DM, Costello JF, Evans JM, Green CP, Price JF, Sampson AP, Spencer DA 1991 Leukotrienes and inflammatory lung disease. Ann NY Acad Sci 629:112-119.
37. Samuelsson B, Dahlen SE, Lindgren JA, Rouzer CA, Serhan CN 1987 Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science 237:1171-1176.
38. Chen XS, Sheller JR, Johnson EN, Funk CD 1994 Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Nature 372:179-182.