Molecular mechanism of pancreatic tumor metastasis inhibition by Gd@C 82(OH)22 and its implication for de novo design of nanomedicine

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 38, 2012, Pages 15431-15436

  Kang, Seung Gu ^a   Zhou, Guoqiang ^b   Yang, Ping ^c   Liu, Ying ^d   Sun, Baoyun ^b   Huynh, Tien ^a   Meng, Huan ^b   Zhao, Lina ^b   Xing, Gengmei ^b   Chen, Chunying ^b,d   Zhao, Yuliang ^b,d   Zhou, Ruhong ^a,e  

^a IBM T J WATSON RESEARCH CENTER   (United States)

^b INSTITUTE OF HIGH ENERGY PHYSICS   (China)

^c PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^d NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^e Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Antiangiogenesis; Indirect inhibition mode; Inhibition of MMPs; Tumor metastasis

Indexed keywords

GELATINASE B; METALLOFULLERENOL; NANOPARTICLE; UNCLASSIFIED DRUG; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; NANOMEDICINE; NONHUMAN; PANCREAS METASTASIS; PRIORITY JOURNAL; STATIC ELECTRICITY; TUMOR XENOGRAFT;

ANIMALS; CATALYTIC DOMAIN; DRUG DESIGN; EXTRACELLULAR MATRIX; FULLERENES; GADOLINIUM; HUMANS; HYDROGEN BONDING; IONS; LIGANDS; MATRIX METALLOPROTEINASE INHIBITORS; MATRIX METALLOPROTEINASES; MICE; NANOMEDICINE; NANOPARTICLES; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; PANCREATIC NEOPLASMS; ZINC;

ANIMALIA; MUS MUSCULUS;

EID: 84866532149     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1204600109     Document Type: Article

References (27)

1. Klein CA (2008) Cancer. The metastasis cascade. Science 321:1785-1787.
2. Chiang AC, Massagué J (2008) Molecular basis of metastasis. N Engl J Med 359: 2814-2823.
3. Carmeliet P, Jain RK (2000) Angiogenesis in cancer and other diseases. Nature 407: 249- 257.
4. Deryugina EI, Quigley JP (2010) Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: Contrasting, overlapping and compensatory functions. Biochim Biophys Acta 1803:103- 120.
5. Stathis A, Moore MJ (2010) Advanced pancreatic carcinoma: Current treatment and future challenges. Nat Rev Clin Oncol 7:163-172.
6. Chen C, et al. (2005) Multihydroxylated [Gd@C82(OH)22]n nanoparticles: Antineoplastic activity of high efficiency and low toxicity. Nano Lett 5:2050-2057. (Pubitemid 41546336)
7. Bolskar RD, et al. (2003) First soluble M@C60 derivatives provide enhanced access to metallofullerenes and permit in vivo evaluation of Gd@C60[C(COOH)2]10 as a MRI contrast agent. J Am Chem Soc 125:5471-5478. (Pubitemid 36588345)
8. Cagle DW, Kennel SJ, Mirzadeh S, Alford JM, Wilson LJ (1999) In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers. Proc Natl Acad Sci USA 96:5182-5187. (Pubitemid 29214557)
9. Kato H, et al. (2003) Lanthanoid endohedral metallofullerenols for MRI contrast agents. J Am Chem Soc 125:4391-4397. (Pubitemid 36512335)
10. Vu TH, et al. (1998) MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 93:411-422. (Pubitemid 28232085)
11. Bergers G, et al. (2000) Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2:737-744.
12. Huang S, et al. (2002) Contributions of stromal metalloproteinase-9 to angiogenesis and growth of human ovarian carcinoma in mice. J Natl Cancer Inst 94:1134-1142. (Pubitemid 34919050)
13. Jodele S, et al. (2005) The contribution of bone marrow-derived cells to the tumor vasculature in neuroblastoma is matrix metalloproteinase-9 dependent. Cancer Res 65:3200-3208. (Pubitemid 40524602)
14. Heissig B, et al. (2005) Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization. J Exp Med 202:739-750. (Pubitemid 41345963)
15. Chantrain CF, et al. (2004) Stromal matrix metalloproteinase-9 regulates the vascular architecture in neuroblastoma by promoting pericyte recruitment. Cancer Res 64: 1675-1686. (Pubitemid 38428689)
16. Meng H, et al. (2010) Potent angiogenesis inhibition by the particulate form of fullerene derivatives. ACS Nano 4:2773-2783.
17. Zuo G, Huang Q, Wei G, Zhou R, Fang H (2010) Plugging into proteins: Poisoning protein function by a hydrophobic nanoparticle. ACS Nano 4:7508-7514.
18. Ge C, et al. (2011) Binding of blood proteins to carbon nanotubes reduces cytotoxicity. Proc Natl Acad Sci USA 108:16968-16973.
19. Jacobsen JA, Major Jourden JL, Miller MT, Cohen SM (2010) To bind zinc or not to bind zinc: An examination of innovative approaches to improved metalloproteinase inhibition. Biochim Biophys Acta 1803:72- 94.
20. Overall CM, Kleifeld O (2006) Towards third generation matrix metalloproteinase inhibitors for cancer therapy. Br J Cancer 94:941-946.
21. Tallant C, Marrero A, Gomis-Rüth FX (2010) Matrix metalloproteinases: Fold and function of their catalytic domains. Biochim Biophys Acta 1803:20-28.
22. Overall CM, López-Otín C (2002) Strategies for MMP inhibition in cancer: Innovations for the post-trial era. Nat Rev Cancer 2:657-672. (Pubitemid 37328917)
23. Martens E, et al. (2007) A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains. Biochim Biophys Acta 1770:178-186. (Pubitemid 46017074)
24. Xu X, Chen Z, Wang Y, Bonewald L, Steffensen B (2007) Inhibition of MMP-2 gelatinolysis by targeting exodomain-substrate interactions. Biochem J 406:147-155. (Pubitemid 47264745)
25. Engel CK, et al. (2005) Structural basis for the highly selective inhibition of MMP-13. Chem Biol 12:181-189. (Pubitemid 40281325)
26. Tan RC, Truong TN, McCammon JA, Sussman JL (1993) Acetylcholinesterase: Electrostatic steering increases the rate of ligand binding. Biochemistry 32:401-403. (Pubitemid 23034875)
27. Wade RC, Gabdoulline RR, Lüdemann SK, Lounnas V (1998) Electrostatic steering and ionic tethering in enzyme-ligand binding: Insights from simulations. Proc Natl Acad Sci USA 95:5942-5949. (Pubitemid 28248943)