The periconceptional environment and cardiovascular disease: Does in vitro embryo culture and transfer influence cardiovascular development and health?

Nutrients

Volumn 7, Issue 3, 2015, Pages 1378-1425

  Padhee, Monalisa ^a   Zhang, Song ^a   Lie, Shervi ^a   Wang, Kimberley C ^a   Botting, Kimberley J ^a   Caroline McMillen, I ^a   Maclaughlin, Severence M ^a   Morrison, Janna L ^a  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

Assisted reproductive technology; Cardiovascular disease; Epigenetics; In vitro fertilization; Periconceptional period

Indexed keywords

ANGIOTENSIN II; CCAAT ENHANCER BINDING PROTEIN ALPHA; FOLLITROPIN; GLUCOSYLTRANSFERASE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 7; LUTEINIZING HORMONE; MESODERM SPECIFIC TRANSCRIPT HOMOLOG PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RECOMBINANT PROTEIN; SMALL NUCLEAR RIBONUCLEOPROTEIN; SOMATOMEDIN B; SOMATOMEDIN B RECEPTOR; UNCLASSIFIED DRUG;

CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONCEPTION; CONGENITAL HEART MALFORMATION; CONTROLLED CLINICAL TRIAL (TOPIC); DNA METHYLATION; EMBRYO CULTURE; EMBRYO DEVELOPMENT; EMBRYO TRANSFER; EPIGENETICS; FERTILIZATION; FETUS DEVELOPMENT; GASTRULATION; GENE ACTIVATION; HUMAN; INFERTILITY THERAPY; MULTICENTER STUDY (TOPIC); NONHUMAN; OOCYTE DEVELOPMENT; OVARY HYPERSTIMULATION; OVULATION; REVIEW; SUPEROVULATION; ADVERSE EFFECTS; ANIMAL; CARDIOVASCULAR DISEASES; FEMALE; IN VITRO FERTILIZATION; PREGNANCY; PREGNANCY OUTCOME;

ANIMALIA;

ANIMALS; CARDIOVASCULAR DISEASES; EMBRYONIC DEVELOPMENT; FEMALE; FERTILIZATION IN VITRO; HUMANS; PREGNANCY; PREGNANCY OUTCOME;

EID: 84923164397     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu7031378     Document Type: Review

References (308)

1. Jurema, M.W.; Nogueira, D. In vitro maturation of human oocytes for assisted reproduction. Fertil. Steril. 2006, 86, 1277–1291.
2. Fleming, T.P.; Kwong, W.Y.; Porter, R.; Ursell, E.; Fesenko, I.; Wilkins, A.; Miller, D.J.; Watkins, A.J.; Eckert, J.J. The embryo and its future. Biol. Reprod. 2004, 71, 1046–1054.
3. Louis, G.M.B.; Cooney, M.A.; Lynch, C.D.; Handal, A. Periconception window: Advising the pregnancy-planning couple. Fertil. Steril. 2008, 89, e119–e121.
4. Czeizel, A.E. Prevention of congenital abnormalities by periconceptional multivitamin supplementation. BMJ 1993, 306, 1645–1648.
5. Van Uitert, E.M.; van der Elst-Otte, N.; Wilbers, J.J.; Exalto, N.; Willemsen, S.P.; Eilers, P.H.C.; Koning, A.H.J.; Steegers, E.A.P.; Steegers-Theunissen, R.P.M. Periconception maternal characteristics and embryonic growth trajectories: The Rotterdam Predict Study. Hum. Reprod. 2013, 28, 3188–3196.
6. Schelbach, C.J.; Robker, R.L.; Bennett, B.D.; Gauld, A.D.; Thompson, J.G.; Kind, K.L. Altered pregnancy outcomes in mice following treatment with the hyperglycaemia mimetic, glucosamine, during the periconception period. Reprod. Fertil. Dev. 2013, 25, 405–416.
7. Watkins, A.J.; Lucas, E.S.; Wilkins, A.; Cagampang, F.R.A.; Fleming, T.P. Maternal periconceptional and gestational low protein diet affects mouse offspring growth, cardiovascular and adipose phenotype at 1 year of age. PLoS One 2011, 6, e28745.
8. Maloney, C.A.; Hay, S.M.; Reid, M.D.; Duncan, G.; Nicol, F.; Sinclair, K.D.; Rees, W.D. A methyl-deficient diet fed to rats during the pre- and peri-conception periods of development modifies the hepatic proteome in the adult offspring. Genes Nutr. 2013, 8, 181–190.
9. Kwong, W.Y.; Miller, D.J.; Ursell, E.; Wild, A.E.; Wilkins, A.P.; Osmond, C.; Anthony, F.W.; Fleming, T.P. Imprinted gene expression in the rat embryo-fetal axis is altered in response to periconceptional maternal low protein diet. Reproduction 2006, 132, 265–277.
10. Bloomfield, F.H. Periconceptional undernutrition in sheep accelerates maturation of the fetal hypothalamic-pituitary-adrenal axis in late gestation. Endocrinology 2004, 145, 4278–4278.
11. Oliver, M.H.; Hawkins, P.; Harding, J.E. Periconceptional undernutrition alters growth trajectory and metabolic and endocrine responses to fasting in late-gestation fetal sheep. Pediatr. Res. 2005, 57, 591–598.
12. Spencer, T.E.; Johnson, G.A.; Bazer, F.W.; Burghardt, R.C. Implantation mechanisms: Insights from the sheep. Reproduction 2004, 128, 657–668.
13. Gardner, D.S.; van Bon, B.W.M.; Dandrea, J.; Goddard, P.J.; May, S.F.; Wilson, V.; Stephenson, T.; Symonds, M.E. Effect of periconceptional undernutrition and gender on hypothalamicpituitary- adrenal axis function in young adult sheep. J. Endocrinol. 2006, 190, 203–212.
14. Bazer, F.W.; Wu, G.; Johnson, G.A.; Kim, J.; Song, G. Uterine histotroph and conceptus development: select nutrients and secreted phosphoprotein 1 affect mechanistic target of rapamycin cell signaling in ewes. Biol. Reprod. 2011, 85, 1094–1107.
15. Zhang, S.; Rattanatray, L.; Morrison, J.L.; Nicholas, L.M.; Lie, S.; McMillen, I.C. Maternal obesity and the early origins of childhood obesity: Weighing up the benefits and costs of maternal weight loss in the periconceptional period for the offspring. Exp. Diabetes Res. 2011, 2011, 10.
16. Edwards, L.J.; McFarlane, J.R.; Kauter, K.G.; McMillen, I.C. Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005, 288, R39–45.
17. Torrens, C.; Snelling, T.H.; Chau, R.; Shanmuganathan, M.; Cleal, J.K.; Poore, K.R.; Noakes, D.E.; Poston, L.; Hanson, M.A.; Green, L.R. Effects of pre- and periconceptional undernutrition on arterial function in adult female sheep are vascular bed dependent. Exp. Physiol. 2009, 94, 1024–1033.
18. Edwards, L.J.; McMillen, I.C. Impact of maternal undernutrition during the periconceptional period, fetal number, and fetal sex on the development of the hypothalamo-pituitary adrenal axis in sheep during late gestation. Biol. Reprod. 2002, 66, 1562–1569.
19. MacLaughlin, S.M.; Mühlhäusler, B.S.; Gentili, S.; McMillen, I.C. When in gestation do nutritional alterations exert their effects? A focus on the early origins of adult disease. Curr. Opin. Endocrinol. Diabetes Obes. 2006, 13, 516–522.
20. McMillen, I.C.; MacLaughlin, S.M.; Muhlhausler, B.S.; Gentili, S.; Duffield, J.L.; Morrison, J.L. Developmental origins of adult health and disease: The role of periconceptional and foetal nutrition. Basic Clin. Pharmacol. Toxicol. 2008, 102, 82–89.
21. Bachvarova, R. Gene expression during oogenesis and oocyte development in mammals. In Oogenesis; Browder, L., Ed.; Springer US: New York, NY, USA, 1985; Volume 1, pp. 453–524.
22. Eddy, E.; Clark, J.M.; Gong, D.; Fenderson, B.A. Origin and migration of primordial germ cells in mammals. Gamete Res. 1981, 4, 333–362.
23. Schoenwolf, G.C., Bleyl, S.; Brauer, P.R.; Francis-West, P.H. Larsen’s Human Embryology; Churchill Livingstone/Elsevier Philadelphia: Philadelphia, PA, USA, 2009.
24. Carlson, B.M. Human Embryology and Developmental Biology; Elsevier Health Sciences: Philadelphia, PA, USA, 2013.
25. Wilcox, A.J. Fertility and Pregnancy: An Epidemiologic Perspective: An Epidemiologic Perspective; Oxford University Press: USA: New York, NY, USA, 2010.
26. Gougeon, A. Regulation of ovarian follicular development in primates: Facts and hypotheses. Endocr. Rev. 1996, 17, 121–155.
27. Bernal, A.B.; Vickers, M.H.; Hampton, M.B.; Poynton, R.A.; Sloboda, D.M. Maternal undernutrition significantly impacts ovarian follicle number and increases ovarian oxidative stress in adult rat offspring. PLoS One 2010, 5, e15558.
28. Connor, K.L.; Vickers, M.H.; Beltrand, J.; Meaney, M.J.; Sloboda, D.M. Nature, nurture or nutrition? Impact of maternal nutrition on maternal care, offspring development and reproductive function. J. Physiol. 2012, 590, 2167–2180.
29. Sloboda, D.M.; Hickey, M.; Hart, R. Reproduction in females: The role of the early life environment. Hum. Reprod. Update 2011, 17, 210–227.
30. Guzmán, C.; Cabrera, R.; Cárdenas, M.; Larrea, F.; Nathanielsz, P.W.; Zambrano, E. Protein restriction during fetal and neonatal development in the rat alters reproductive function and accelerates reproductive ageing in female progeny. J. Physiol. 2006, 572, 97–108.
31. Intapad, S.; Alexander, B.T. The double hit of growth restriction: Its origins and outcome on this generation and the next. J. Physiol. 2012, 590, 1019–1019.
32. Gallo, L.A.; Tran, M.; Moritz, K.M.; Jefferies, A.J.; Wlodek, M.E. Pregnancy in aged rats that were born small: Cardiorenal and metabolic adaptations and second-generation fetal growth. FASEB J. 2012, 26, 4337–4347.
33. Torrens, C.; Poston, L.; Hanson, M.A. Transmission of raised blood pressure and endothelial dysfunction to the F2 generation induced by maternal protein restriction in the F0, in the absence of dietary challenge in the F1 generation. Br. J. Nutr. 2008, 100, 760–766.
34. Benyshek, D.C.; Johnston, C.S.; Martin, J.F.; Ross, W.D. Insulin sensitivity is normalized in the third generation (F3) offspring of developmentally programmed insulin resistant (F2) rats fed an energy-restricted diet. Nutr. Metab. (Lond.) 2008, 5, 26.
35. Kott, R. Montana farm flock sheep production handbook. In Animal & Range Sciences, Extension Service; Montana State University: Bozeman, MT, USA, 2006.
36. Wilcox, A.J.; Dunson, D.; Baird, D.D. The timing of the “fertile window” in the menstrual cycle: Day specific estimates from a prospective study. BMJ 2000, 321, 1259–1262.
37. Long, J.A.; Evans, H.M. The Oestrous Cycle in the Rat and Its Associated Phenomena; University of California Press: Berkeley, CA, USA, 1922; Volume 6.
38. Allen, E. The oestrous cycle in the mouse. Am. J. Anat. 1922, 30, 297–371.
39. Fortune, J.E. Ovarian follicular growth and development in mammals. Biol. Reprod. 1994, 50, 225–232.
40. Hirshfield, A.N. Development of follicles in the mammalian ovary. Int. Rev. Cytol. 1991, 124, 43–101.
41. McGee, E.A.; Hsueh, A.J. Initial and cyclic recruitment of ovarian follicles. Endocr. Rev. 2000, 21, 200–214.
42. Wassarman, P.M. Zona Pellucida Glycoproteins. Annu. Rev. Biochem. 1988, 57, 415–442.
43. Hill, M.A. Embryology Fertilization. Available online: https://php.med.unsw.edu.au/embryology/ index.php?title=Fertilization (accessed on 18 November 2014).
44. Senger, P.L. Pathways to Pregnancy and Parturition; 1st ed.; Current Conceptions, Inc.: Pullman, WA, USA, 1999; pp. 206–246.
45. Krisher, R.L. The effect of oocyte quality on development. J. Anim. Sci. 2004, 82, E14–E23.
46. Ertzeid, G.; Storeng, R. The impact of ovarian stimulation on implantation and fetal development in mice. Hum. Reprod. 2001, 16, 221–225.
47. Van der Auwera, I.; D’Hooghe, T. Superovulation of female mice delays embryonic and fetal development. Hum. Reprod. 2001, 16, 1237–1243.
48. Kelley-Quon, L.I.; Tseng, C.-H.; Janzen, C.; Shew, S.B. Congenital malformations associated with assisted reproductive technology: A California statewide analysis. J. Pediatr. Surg. 2013, 48, 1218–1224.
49. Ceelen, M.; van Weissenbruch, M.M.; Vermeiden, J.P. W.; van Leeuwen, F.E.; Delemarre-van de Waal, H.A. Growth and development of children born after in vitro fertilization. Fertil. Steril. 2008, 90, 1662–1673.
50. Sutcliffe, A.G.; Ludwig, M. Outcome of assisted reproduction. Lancet 2007, 370, 351–359.
51. Stouder, C.; Deutsch, S.; Paoloni-Giacobino, A. Superovulation in mice alters the methylation pattern of imprinted genes in the sperm of the offspring. Reprod. Toxicol. 2009, 28, 536–541.
52. Fernández-Gonzalez, R.; Moreira, P.; Bilbao, A.; Jiménez, A.; Pérez-Crespo, M.; Ramírez, M.A.; de Fonseca, F.R.; Pintado, B.; Gutiérrez-Adán, A. Long-term effect of in vitro culture of mouse embryos with serum on mRNA expression of imprinting genes, development, and behavior. Proc. Natl. Acad. Sci. USA 2004, 101, 5880–5885.
53. Mainigi, M.A.; Olalere, D.; Burd, I.; Sapienza, C.; Bartolomei, M.; Coutifaris, C. Peri-implantation hormonal milieu: Elucidating mechanisms of abnormal placentation and fetal growth. Biol. Reprod. 2014, 90, 26.
54. Fauque, P.; Mondon, F.; Letourneur, F.; Ripoche, M.-A.; Journot, L.; Barbaux, S.; Dandolo, L.; Patrat, C.; Wolf, J.-P.; Jouannet, P., et al. In vitro fertilization and embryo culture strongly impact the placental transcriptome in the mouse model. PLoS One 2010, 5, e9218.
55. Alikani, M.; Calderon, G.; Tomkin, G.; Garrisi, J.; Kokot, M.; Cohen, J. Cleavage anomalies in early human embryos and survival after prolonged culture in vitro. Hum. Reprod. 2000, 15, 2634–2643.
56. Young, L.E.; Fernandes, K.; McEvoy, T.G.; Butterwith, S.C.; Gutierrez, C.G.; Carolan, C.; Broadbent, P.J.; Robinson, J.J.; Wilmut, I.; Sinclair, K.D. Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture. Nat. Genet. 2001, 27, 153–154.
57. Watkins, A.J.; Fleming, T.P. Blastocyst environment and its influence on offspring cardiovascular health: The heart of the matter. J. Anat. 2009, 215, 52–59.
58. McEvoy, T.G.; Sinclair, K.D.; Young, L.E.; Wilmut, I.; Robinson, J.J. Large offspring syndrome and other consequences of ruminant embryo culture in vitro: Relevance to blastocyst culture in human ART. Hum. Fertil. 2000, 3, 238–246.
59. Khosla, S.; Dean, W.; Brown, D.; Reik, W.; Feil, R. Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes. Biol. Reprod. 2001, 64, 918–926.
60. Watkins, A.J.; Platt, D.; Papenbrock, T.; Wilkins, A.; Eckert, J.J.; Kwong, W.Y.; Osmond, C.; Hanson, M.; Fleming, T.P. Mouse embryo culture induces changes in postnatal phenotype including raised systolic blood pressure. Proc. Natl. Acad. Sci. USA 2007, 104, 5449–5454.
61. Rimoldi, S.F.; Sartori, C.; Rexhaj, E.; Cerny, D.; Von Arx, R.; Soria, R.; Germond, M.; Allemann, Y.; Scherrer, U. Vascular dysfunction in children conceived by assisted reproductive technologies: Underlying mechanisms and future implications. Swiss Med. Wkly. 2014, 144, w13973.
62. Valbuena, D.; Jasper, M.; Remohí, J.; Pellicer, A.; Simón, C. Ovarian stimulation nd endometrial receptivity. Hum. Reprod. 1999, 14, 107–111.
63. Ruiz-Alonso, M.; Blesa, D.; Simón, C. The genomics of the human endometrium. Biochim. Biophys. Acta—Mol. Basis Dis. 2012, 1822, 1931–1942.
64. Rahman, A.; Abdullah, R.; Wan-Khadijah, W. Gametogenesis, fertilization and early embryogenesis in mammals with special reference to goat: A review. J. Biol. Sci. 2008, 8, 1115–1128.
65. Ecochard, R.; Gougeon, A. Side of ovulation and cycle characteristics in normally fertile women. Hum. Reprod. 2000, 15, 752–755.
66. Minami, N.; Suzuki, T.; Tsukamoto, S. Zygotic Gene Activation and Maternal Factors in Mammals. J. Reprod. Dev. 2007, 53, 707–715.
67. Zernicka-Goetz, M. Activation of embryonic genes during preimplantation rat development. Mol. Reprod. Dev. 1994, 38, 30–35.
68. Young, W.C.; Boling, J.L.; Blandau, R.J. The vaginal smear picture, sexual receptivity and time of ovulation in the albino rat. Anat. Rec. 1941, 80, 37–45.
69. Green, E.L. Biology of the laboratory mouse. Dover Publications Inc.: New York, NY, USA, 1966.
70. Hill, M.A. Embryology Rat Development. Available online: https://php.med.unsw.edu.au/ embryology/index.php?title=Rat_Development (accessed on 20 November 2014).
71. Hill, M.A. Embryology Mouse Development. Available online: https://php.med.unsw.edu.au/ embryology/index.php?title=Mouse_Development (accessed on 20 November 2014).
72. Spencer, T.E.; Johnson, G.A.; Bazer, F.W.; Burghardt, R.C.; Palmarini, M. Pregnancy recognition and conceptus implantation in domestic ruminants: Roles of progesterone, interferons and endogenous retroviruses. Reprod. Fertil. Dev. 2006, 19, 65–78.
73. Schultz, R.M. The molecular foundations of the maternal to zygotic transition in the preimplantation embryo. Hum. Reprod. Update 2002, 8, 323–331.
74. Schultz, R.M. Regulation of zygotic gene activation in the mouse. Bioessays 1993, 15, 531–538.
75. Li, L.; Lu, X.; Dean, J. The Maternal to Zygotic Transition in Mammals. Mol. Asp. Med. 2013, 34, 919–938.
76. Kafri, T.; Ariel, M.; Brandeis, M.; Shemer, R.; Urven, L.; McCarrey, J.; Cedar, H.; Razin, A. Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line. Genes Dev. 1992, 6, 705–714.
77. Stojanov, T.; O’Neill, C. Ontogeny of expression of a receptor for platelet-activating factor in mouse preimplantation embryos and the effects of fertilization and culture in vitro on its expression. Biol. Reprod.1999, 60, 674–682.
78. Stojanov, T.; O’neill, C. In vitro fertilization causes epigenetic modifications to the onset of gene expression from the zygotic genome in mice. Biol. Reprod.2001, 64, 696–705.
79. Van Voorhis, B.J. In vitro fertilization. N. Engl. J. Med. 2007, 356, 379–386.
80. Abyholm, T.; Tanbo, T. GIFT, ZIFT, and related techniques. Curr. Opin. Obstet. Gynecol. 1993, 5, 615–622.
81. Sutherland, J.E.; Costa, M.A.X. Epigenetics and the environment. Ann. N. Y. Acad. Sci. 2003, 983, 151–160.
82. Egger, G.; Liang, G.; Aparicio, A.; Jones, P.A. Epigenetics in human disease and prospects for epigenetic therapy. Nature 2004, 429, 457–463.
83. Tchurikov, N.A. Molecular mechanisms of epigenetics. Biochemistry (Moscow) 2005, 70, 406–423.
84. Gu, L.; Wang, Q.; Sun, Q.Y. Histone modifications during mammalian oocyte maturation: Dynamics, regulation and functions. Cell Cycle 2010, 9, 1942–1950.
85. Reik, W.; Dean, W.; Walter, J. Epigenetic reprogramming in mammalian development. Science 2001, 293, 1089–1093.
86. Morgan, H.D.; Santos, F.; Green, K.; Dean, W.; Reik, W. Epigenetic reprogramming in mammals. Hum. Mol. Genet. 2005, 14, R47–R58.
87. Santos, F.; Dean, W. Epigenetic reprogramming during early development in mammals. Reproduction 2004, 127, 643–651.
88. Mayer, W.; Niveleau, A.; Walter, J.; Fundele, R.; Haaf, T. Embryogenesis: Demethylation of the zygotic paternal genome. Nature 2000, 403, 501–502.
89. Allegrucci, C.; Thurston, A.; Lucas, E.; Young, L. Epigenetics and the germline. Reproduction 2005, 129, 137–149.
90. Li, E.; Beard, C.; Jaenisch, R. Role for DNA methylation in genomic imprinting. Nature 1993, 366, 362–365.
91. Reik, W.; Walter, J. Genomic imprinting: Parental influence on the genome. Nat. Rev. Genet. 2001, 2, 21–32.
92. Rodriguez-Osorio, N.; Dogan, S.; Memili, E. Epigenetics of mammalian gamete and embryo development. In Livestock Epigenetics; 1st ed.; Hassan, K.; Ed.; Wiley-Blackwell: Oxford, UK, 2011; pp. 3–25.
93. De Rycke, M.; Liebaers, I.; van Steirteghem, A. Epigenetic risks related to assisted reproductive technologies: Risk analysis and epigenetic inheritance. Hum. Reprod. 2002, 17, 2487–2494.
94. Reik, W.; Constância, M.; Fowden, A.; Anderson, N.; Dean, W.; Ferguson-Smith, A.; Tycko, B.; Sibley, C. Regulation of supply and demand for maternal nutrients in mammals by imprinted genes. J. Physiol. 2003, 547, 35–44.
95. Lambertini, L.; Marsit, C.J.; Sharma, P.; Maccani, M.; Ma, Y.; Hu, J.; Chen, J. Imprinted gene expression in fetal growth and development. Placenta 2012, 33, 480–486.
96. Abu-Amero, S.; Monk, D.; Apostolidou, S.; Stanier, P.; Moore, G. Imprinted genes and their role in human fetal growth. Cytogenet. Genome Res. 2006, 113, 262–270.
97. Hall, J.G. Genomic imprinting: Review and relevance to human diseases. Am. J. Hum. Genet. 1990, 46, 857–873.
98. Amor, D.J.; Halliday, J. A review of known imprinting syndromes and their association with assisted reproduction technologies. Hum. Reprod. 2008, 23, 2826–2834.
99. Dominguez-Salas, P.; Moore, S.E.; Baker, M.S.; Bergen, A.W.; Cox, S.E.; Dyer, R.A.; Fulford, A.J.; Guan, Y.; Laritsky, E.; Silver, M.J., et al. Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nat. Commun. 2014, 5, doi:10.1038/ncomms4746.
100. Niemitz, E.L.; Feinberg, A.P. Epigenetics and assisted reproductive technology: A call for investigation. Am. J. Hum. Genet. 2004, 74, 599–609.
101. Schieve, L.A.; Meikle, S.F.; Ferre, C.; Peterson, H.B.; Jeng, G.; Wilcox, L.S. Low and very low birth weight in infants conceived with use of assisted reproductive technology. N. Engl. J. Med. 2002, 346, 731–737.
102. Zegers-Hochschild, F.; Adamson, G.D.; de Mouzon, J.; Ishihara, O.; Mansour, R.; Nygren, K.; Sullivan, E.; van der Poel, S. The International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary on ART terminology, 2009. Hum. Reprod. 2009, 24, 2683–2687.
103. Heape, W. Preliminary note on the transplantation and grwoth of mammalian ova within a uterine foster mother. Proc. R. Soc. 1890, 48, 457–458.
104. Betteridge, K.J. Reflections on the golden anniversary of the first embryo transfer to produce a calf. Theriogenology 2000, 53, 3–10.
105. De Kretzer, D.; Dennis, P.; Hudson, B.; Leeton, J.; Lopata, A.; Outch, K.; Talbot, J.; Wood, C. Transfer of a human zygote. Lancet 1973, 302, 728–729.
106. Steptoe, P.C.; Edwards, R.G. Birth after the reimplantation of a human embryo. Lancet 1978, 312, 366–366.
107. Kamel, R.M. Assisted reproductive technology after the birth of louise brown. J. Reprod. Infertil. 2013, 14, 96–109.
108. ART Fact Sheet. Available online: http://www.eshre.eu/sitecore/content/Home/Guidelines%20 and%20Legal/ART%20fact%20sheet (accessed on 16 November 2014).
109. Balasch, J. Investigation of the infertile couple: Investigation of the infertile couple in the era of assisted reproductive technology: A time for reappraisal. Hum. Reprod. 2000, 15, 2251–2257.
110. Wyndham, N.; Marin Figueira, P.G.; Patrizio, P. A persistent misperception: Assisted reproductive technology can reverse the “aged biological clock”. Fertil. Steril. 2012, 97, 1044–1047.
111. Hilder, L.; Zhichao, Z.; Parker, M., Jahan, S., Chambers G.M. Australia's mothers and babies 2012; Perinatal statistics series no. 30. Cat. no. PER 69. Australian Institute of Health and Welfare and University: Canberra, Australia, 2014.
112. Nash, M. Making ‘Postmodern’ Mothers: Pregnant Embodiment, Baby Bumps and Body Image. Palgrave Macmillan: England, UK, 2012.
113. Australian Institute of Family Studies. Available online: http://www.aifs.gov.au/institute/ info/charts/births/#age (accessed on 16 November 2014).
114. Martin, J.A.; Hamilton, B.E.; Osterman, M.J.K.; Curtin, S.C.; Mathews, T.J. Births: Final Data for 2012; National Vital Statistics Reports, Vol 62 No 9; National Center for Health Statistics: Hyattsville, MD, USA, 30 December 2013.
115. Millan, A. Fertility: Overview, 2008; Report on the Demographic Situation in Canada, Catalogue no. 91-209-X.; Authority of the Minister responsible for Statistics Canada: Ottawa, Canada, August 2011.
116. Dunson, D.B.; Colombo, B.; Baird, D.D. Changes with age in the level and duration of fertility in the menstrual cycle. Hum. Reprod. 2002, 17, 1399–1403.
117. Van Noord-Zaadstra, B.M.; Looman, C.W.; Alsbach, H.; Habbema, J.D.; te Velde, E.R.; Karbaat, J. Delaying childbearing: Effect of age on fecundity and outcome of pregnancy. BMJ 1991, 302, 1361.
118. Hassan, M.A.; Killick, S.R. Effect of male age on fertility: Evidence for the decline in male fertility with increasing age. Fertil. Steril. 2003, 79, 1520–1527.
119. Leridon, H. Can assisted reproduction technology compensate for the natural decline in fertility with age? A model assessment. Hum. Reprod. 2004, 19, 1548–1553.
120. Macaldowie, A.; Wang, Y.A.; Chambers, G.M.; Sullivan, E.A. Assisted Reproductive Technology in Australia and New Zealand 2012; AIHW: Canberra, Australia, 2012.
121. Moore, K.; Thatcher, W.W. Major advances associated with reproduction in dairy cattle. J. Dairy Sci. 2006, 89, 1254–1266.
122. Sejian, V.; Meenambigai, T.V.; Chandirasegaran, M.; Naqvi, S.M.K. reproductive technology in farm animals: New facets and findings: A review. J. Biol. Sci. 2010, 10, 686–700.
123. Chakravarthi, P.; Balaji, N. Use of assisted reproductive technologies for livestock development. Vet. World 2010, 3, 238–240.
124. Amiridis, G.S.; Cseh, S. Assisted reproductive technologies in the reproductive management of small ruminants. Anim. Reprod. Sci. 2012, 130, 152–161.
125. Bertolini, M.; Bertolini, L.R. Advances in reproduc tive technologies in cattle: From artificial insemination to cloning. Rev. Med. Vet. Zoot. 2009, 56, 184–194.
126. Solti, L.; Crichton, E.G.; Loskutoff, N.M.; Cseh, S. Economical and ecological importance of indigenous livestock and the application of assisted reroduction to their preservation. Theriogenology 2000, 53, 149–162.
127. Barbieri, E.; kashyap, S.; Chung, P. Infertility and in vitro fertilization. In Priniciples of Gender Specific Medicine, 2nd ed.; Legato, M.J., Ed.; Academic Press: San Diego, CA, USA, 2010; pp. 381–398.
128. Tanbo, T.; Omland, A.; Dale, P.O.; Åbyholm, T. In vitro fertilization/embryo transfer in unexplained infertility and minimal peritoneal endometriosis. Acta Obstet. Gynecol. Scand. 1995, 74, 539–543.
129. Chandler, C.J.; Harris, C.P. Gamete intrafallopian transfer. Br. J. Hosp. Med. 1996, 55, 468–471.
130. Carnevale, E.M. Gamete intrafallopian transfer. Vet. Clin. N. Am. Equine Pract. 1996, 12, 47–60.
131. Jansen, R.P.S. Gamete intra-fallopian transfer. In Clinical in Vitro Fertilization; Springer London: London, UK, 1989; pp. 63–80.
132. Molloy, D.; Speirs, A.; Du Plessis, Y.; Gellert, S.; Bourne, H.; Johnston, W.I. Gamete intra-fallopian transfer. Med. J. Aust. 1985, 143, 428.
133. Perone, N. Gamete intrafallopian transfer (GIFT): Historic perspective. J. Vitr. Fertil. Embryo Transf. 1991, 8, 1–4.
134. Asch, R.H.; Balmaceda, J.P.; Cittadini, E.; Casas, P.F.; Gomel, V.; Hohl, M.K.; Johnston, I.; Leeton, J.; Escudero, F.J.R.; Noss, U., et al. Gamete intrafallopian transfer. Ann. N. Y. Acad. Sci. 1988, 541, 722–727.
135. Asch, R.H.; Balmaceda, J.P.; Ellsworth, L.R.; Wong, P.C. Gamete intra-fallopian transfer (GIFT): A new treatment for infertility. Int. J. Fertil. 1985, 30, 41–45.
136. Hummel, W.P.; Kettel, L.M. Assisted reproductive technology: The state of the ART. Ann. Med. 1997, 29, 207–214.
137. Devroey, P.; Staessen, C.; Camus, M.; de Grauwe, E.; Wisanto, A.; van Steirteghem, A.C. Zygote intrafallopian transfer as a successful treatment for unexplained infertility. Fertil. Steril. 1989, 52, 246–249.
138. Hamori, M.; Stuckensen, J.; Rumpf, D.; Kniewald, T.; Kniewald, A.; Marquez, M. Zygote intrafallopian transfer (ZIFT): Evaluation of 42 cases. Fertil. Steril. 1988, 50, 519–521.
139. Palermo, G.; Devroey, P.; Camus, M.; de Grauwe, E.; Khan, I.; Staessen, C.; Wisanto, A.; van Steirteghem, A.C. Zygote intra-Fallopian transfer as an alternative treatment for male infertility. Hum. Reprod. 1989, 4, 412–415.
140. Simpson, R. Assisted Reproductive Technology; NSW Parliamentary Library Research Service: Sydney, Australia, 1998; pp. 1–65.
141. Allen, V.M.; Wilson, R.D.; Cheung, A. Pregnancy outcomes after assisted reproductive technology. J. Obstet. Gynaecol. Can. 2006, 28, 220–250.
142. Wang, Y.A.C.G.; Sullivan, E.A. Assisted Reproductive Technology in Australia and New Zealand 2008; AIHW: Canberra, Australia, 2010.
143. Gianaroli, L.; Plachot, M.; van Kooij, R.; Al-Hasani, S.; Dawson, K.; DeVos, A.; Magli, M.C.; Mandelbaum, J.; Selva, J.; van Inzen, W. ESHRE guidelines for good practice in IVF laboratories. Committee of the special interest group on embryology of the european society of human reproduction and embryology. Hum. Reprod. 2000, 15, 2241–2246.
144. Engmann, L.; Maconochie, N.; Tan, S.L.; Bekir, J. Trends in the incidence of births and multiple births and the factors that determine the probability of multiple birth after IVF treatment. Hum. Reprod. 2001, 16, 2598–2605.
145. Pinborg, A. IVF/ICSI twin pregnancies: Risks and prevention. Hum. Reprod. Update 2005, 11, 575–593.
146. El-Toukhy, T.; Khalaf, Y.; Braude, P. IVF results: Optimize not maximize. Am. J. Obstet. Gynecol. 2006, 194, 322–331.
147. De Sutter, P.; van der Elst, J.; Coetsier, T.; Dhont, M. Single embryo transfer and multiple pregnancy rate reduction in IVF/ICSI: A 5-year appraisal. Reprod. BioMed. Online 2003, 6, 464–469.
148. Khalaf, Y.; El-Toukhy, T.; Coomarasamy, A.; Kamal, A.; Bolton, V.; Braude, P. Selective single blastocyst transfer reduces the multiple pregnancy rate and increases pregnancy rates: A pre- and postintervention study. BJOG 2008, 115, 385–390.
149. Tiitinen, A.; Unkila-Kallio, L.; Halttunen, M.; Hyden-Granskog, C. Impact of elective single embryo transfer on the twin pregnancy rate. Hum. Reprod. 2003, 18, 1449–1453.
150. Menezes, J. Embryo culture systems. In Insights into Infertility Management; 2nd ed.; Jaypee Brothers Medical Publishers: New Delhi, India, 2012; pp. 188–198.
151. Gardner, D.K.; Lane, M. Embryo culture systems. In In Vitro Fertilization: A Practical Approach, Gardner, D.K., Ed.; Informa Healthcare USA, Inc.: New York, NY, USA, 2000; pp. 221–264.
152. Zander-Fox, D.; Lane, M. The Future of Human Embryo Culture Media–Or Have We Reached the Ceiling? In The Human Embryo, Yamada, S., Takakuwa, T., Eds.; InTech: Rijeka, Croatia, 2012; pp. 73–98.
153. Quinn, P. Review of media used in art laboratories. J. Androl.2000, 21, 610–615.
154. Lane, M.; Gardner, D.K. Embryo culture medium: Which is the best? Best Pract. Res. Clin. Obstet. Gynaecol.2007, 21, 83–100.
155. Quinn, P.; Kerin, J.F.; Warnes, G.M. Improved pregnancy rate in human in vitro fertilization with the use of a medium based on the composition of human tubal fluid. Fertil. Steril.1985, 44, 493–498.
156. Gardner, D.K.; Lane, M. Culture and selection of viable blastocysts: A feasible proposition for human IVF? Hum. Reprod. Update1997, 3, 367–382.
157. Gardner, D.K. Mammalian embryo culture in the absence of serum or somatic cell support. Cell Biol. Int.1994, 18, 1163–1180.
158. Gupta, S. Media in ART. In Manual of Assisted Reproductive Technologies and Clinical Embryology, 2nd ed.; Jaypee Brothers Medical Publishers: New Delhi, India, 2012; pp.44–57.
159. Grace, K.S.; Sinclair, K.D. Assisted reproductive technology, epigenetics, and long-term health: A developmental time bomb still ticking. Semin. Reprod. Med.2009, 27, 409–416.
160. Sinclair, K.D.; McEvoy, T.G.; Carolan, C.; Maxfield, E.K.; Maltin, C.A.; Young, L.E.; Wilmut, I.; Robinson, J.J.; Broadbent, P.J. Conceptus growth and development following in vitro culture of ovine embryos in media supplemented with bovine sera. Theriogenology1998, 49, 218–218.
161. Sinclair, K.D.; McEvoy, T.G.; Maxfield, E.K.; Maltin, C.A.; Young, L.E.; Wilmut, I.; Broadbent, P.J.; Robinson, J.J. Aberrant fetal growth and development after in vitro culture of sheep zygotes. J. Reprod. Fertil.1999, 116, 177–186.
162. Fernández-Gonzalez, R.; Ramirez, M.A.; Bilbao, A.; de Fonseca, F.R.; Gutiérrez-Adán, A. Suboptimal in vitro culture conditions: An epigenetic origin of long-term health effects. Mol. Reprod. Dev.2007, 74, 1149–1156.
163. Thompson, J.G.; Gardner, D.K.; Pugh, P.A.; McMillan, W.H.; Tervit, H.R. Lamb birth weight is affected by culture system utilized during in vitro pre-elongation development of ovine embryos. Biol. Reprod.1995, 53, 1385–1391.
164. Gardner, D.K.; Lane, M. Culture of viable human blastocysts in defined sequential serum-free media. Hum. Reprod.1998, 13, 148–159. discussion 160.
165. Holst, N.; Bertheussen, K.; Forsdahl, F.; Hakonsen, M.B.; Hansen, L.J.; Nielsen, H.I. Optimization and simplification of culture conditions in human in vitro fertilization (IVF) and preembryo replacement by serum-free media. J. Vitr. Fertil. Embryo Transf.1990, 7, 47–53.
166. Alwan, A. Global Status Report on Noncommunicable Diseases 2010; World Health Organization: Geneva, Switzerland, 2011.
167. World Health Organization. Global Health Observatory (GHO) Data. Available online: http://www.who.int/gho/ncd/mortality_morbidity/cvd/en/ (accessed on 16 November 2014).
168. Stampfer, M.J.; Hu, F.B.; Manson, J.E.; Rimm, E.B.; Willett, W.C. Primary Prevention of Coronary Heart Disease in Women through Diet and Lifestyle. N. Engl. J. Med.2000, 343, 16–22.
169. Mensah, G.A.; Mendis, S.; Greenland, K.; MacKay, J. The Atlas of Heart Disease and Stroke; World Health Organization: Geneva, Switzerland, 2004.
170. McMillen, I.C.; Robinson, J.S. Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol. Rev.2005, 85, 571–633.
171. Barker, D.J. The developmental origins of adult disease. Eur. J. Epidemiol.2003, 18, 733–736.
172. De Boo, H.A.; Harding, J.E. The developmental origins of adult disease (Barker) hypothesis. Aust. N. Z. J. Obstet. Gynaecol.2006, 46, 4–14.
173. Botting, K.J.; Wang, K.C.; Padhee, M.; McMillen, I.C.; Summers-Pearce, B.; Rattanatray, L.; Cutri, N.; Posterino, G.S.; Brooks, D.A.; Morrison, J.L. Early origins of heart disease: Low birth weight and determinants of cardiomyocyte endowment. Clin. Exp. Pharmacol. Physiol.2012, 39, 814–823.
174. Gluckman, P.D.; Hanson, M.A.; Buklijas, T.; Low, F.M.; Beedle, A.S. Epigenetic mechanisms that underpin metabolic and cardiovascular diseases. Nat. Rev. Endocrinol.2009, 5, 401–408.
175. Chang, C.-P.; Bruneau, B.G. Epigenetics and cardiovascular development. Annu. Rev. Physiol.2012, 74, 41–68.
176. Vallaster, M.; Vallaster, C.D.; Wu, S.M. Epigenetic mechanisms in cardiac development and disease. Acta Biochim. Biophys. Sin.2012, 44, 92–102.
177. Ordovás, J.M.; Smith, C.E. Epigenetics and cardiovascular disease. Nat. Rev. Cardiol.2010, 7, 510–519.
178. Zak, R. Growth of the Heart in Health and Disease; Raven Press: New York, NY, USA, 1984.
179. Nag, A.C. Study of non-muscle cells of the adult mammalian heart: a fine structural analysis and distribution. Cytobios1980, 28, 41–61.
180. Soonpaa, M.H.; Kim, K.K.; Pajak, L.; Franklin, M.; Field, L.J. Cardiomyocyte DNA synthesis and binucleation during murine development. Am. J. Physiol.1996, 271, H2183–H2189.
181. Oparil, S.; Bishop, S.P.; Clubb, F.J. Myocardial cell hypertrophy or hyperplasia. Hypertension1984, 6, III38–III43.
182. Schmid, G.; Pfitzer, P. Mitoses and binucleated cells in perinatal human hearts. Virchows Arch. B1985, 48, 59–67.
183. Burrell, J.H.; Boyn, A.M.; Kumarasamy, V.; Hsieh, A.; Head, S.I.; Lumbers, E.R. Growth and maturation of cardiac myocytes in fetal sheep in the second half of gestation. Anat. Rec. A Discov. Mol. Cell. Evol. Biol.2003, 274, 952–961.
184. Ahuja, P.; Sdek, P.; MacLellan, W.R. Cardiac Myocyte Cell Cycle Control in Development, Disease, and Regeneration. Physiol. Rev.2007, 87, 521–544.
185. Jonker, S.S.; Zhang, L.; Louey, S.; Giraud, G.D.; Thornburg, K.L.; Faber, J.J. Myocyte enlargement, differentiation, and proliferation kinetics in the fetal sheep heart. J. Appl. Physiol.2007, 102, 1130–1142.
186. Woodcock, E.A.; Matkovich, S.J. Cardiomyocytes structure, function and associated pathologies. Int. J. Biochem. Cell Biol.2005, 37, 1746–1751.
187. Walker, S.K.; Hartwich, K.; Robinson, J.S. Long-term effects on offspring of exposure of oocytes and embryos to chemical and physical agents. Hum. Reprod. Update2000, 6, 564–577.
188. Mollova, M.; Bersell, K.; Walsh, S.; Savla, J.; Das, L.T.; Park, S.-Y.; Silberstein, L.E.; dos Remedios, C.G.; Graham, D.; Colan, S., et al. Cardiomyocyte proliferation contributes to heart growth in young humans. Proc. Natl. Acad. Sci. USA 2013, 110, 1446–1451.
189. Clubb, F.J., Jr.; Bishop, S.P. Formation of binucleated myocardial cells in the neonatal rat. An index for growth hypertrophy. Lab. Investig. 1984, 50, 571–577.
190. Porrello, E.R.; Mahmoud, A.I.; Simpson, E.; Hill, J.A.; Richardson, J.A.; Olson, E.N.; Sadek, H.A. Transient regenerative potential of the neonatal mouse heart. Science 2011, 331, 1078–1080.
191. Walsh, S.; Pontén, A.; Fleischmann, B.K.; Jovinge, S. Cardiomyocyte cell cycle control and growth estimation in vivo—An analysis based on cardiomyocyte nuclei. Cardiovasc. Res. 2010, 86, 365–373.
192. Li, F.; Wang, X.; Capasso, J.M.; Gerdes, A.M. Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J. Mol. Cell. Cardiol. 1996, 28, 1737–1746.
193. Roseboom, T.J.; van der Meulen, J.H.P.; Osmond, C.; Barker, D.J.P.; Ravelli, A.C.J.; Schroeder-Tanka, J.M.; van Montfrans, G.A.; Michels, R.P.J.; Bleker, O.P. Coronary heart disease after prenatal exposure to the Dutch famine, 1944–1945. Heart 2000, 84, 595–598.
194. Painter, R.C.; de Rooij, S.R.; Bossuyt, P.M.; Phillips, D.I.; Osmond, C.; Barker, D.J.; Bleker, O.P.; Roseboom, T.J. Blood pressure response to psychological stressors in adults after prenatal exposure to the Dutch famine. J. Hypertens. 2006, 24, 1771–1778.
195. Malik, S.; Cleves, M.A.; Honein, M.A.; Romitti, P.A.; Botto, L.D.; Yang, S.; Hobbs, C.A. National Birth Defects Prevention, S. Maternal Smoking and Congenital Heart Defects. Pediatrics 2008, 121, e810–e816.
196. Karatza, A.A.; Giannakopoulos, I.; Dassios, T.G.; Belavgenis, G.; Mantagos, S.P.; Varvarigou, A.A. Periconceptional tobacco smoking and Xisolated congenital heart defects in the neonatal period. Int. J. Cardiol. 2011, 148, 295–299.
197. Carmichael, S.L.; Shaw, G.M.; Yang, W.; Lammer, E.J. Maternal periconceptional alcohol consumption and risk for conotruncal heart defects. Birth Defects Res. Part A Clin. Mol. Teratol. 2003, 67, 875–878.
198. Van Driel, L.M.J.W.; Smedts, H.P.M.; Helbing, W.A.; Isaacs, A.; Lindemans, J.; Uitterlinden, A.G.; van Duijn, C.M.; de Vries, J.H.M.; Steegers, E.A.P.; Steegers-Theunissen, R.P.M. Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide. Eur. Heart J. 2008, 29, 1424–1431.
199. Kwong, W.Y.; Wild, A.E.; Roberts, P.; Willis, A.C.; Fleming, T.P. Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension. Development 2000, 127, 4195–4202.
200. Watkins, A.J.; Wilkins, A.; Cunningham, C.; Perry, V.H.; Seet, M.J.; Osmond, C.; Eckert, J.J.; Torrens, C.; Cagampang, F.R.A.; Cleal, J., et al. Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring. J. Physiol. 2008, 586, 2231–2244.
201. Watkins, A.J.; Ursell, E.; Panton, R.; Papenbrock, T.; Hollis, L.; Cunningham, C.; Wilkins, A.; Perry, V.H.; Sheth, B.; Kwong, W.Y., et al. Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease. Biol. Reprod. 2008, 78, 299–306.
202. Edwards, L.J.; McMillen, I.C. Periconceptional nutrition programs development of the cardiovascular system in the fetal sheep. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2002, 283, R669–R679.
203. Gardner, D.S.; Pearce, S.; Dandrea, J.; Walker, R.; Ramsay, M.M.; Stephenson, T.; Symonds, M.E. Peri-Implantation undernutrition programs blunted angiotensin ii evoked baroreflex responses in young adult sheep. Hypertension 2004, 43, 1290–1296.
204. Gopalakrishnan, G.S.; Gardner, D.S.; Rhind, S.M.; Rae, M.T.; Kyle, C.E.; Brooks, A.N.; Walker, R.M.; Ramsay, M.M.; Keisler, D.H.; Stephenson, T., et al. Programming of adult cardiovascular function after early maternal undernutrition in sheep. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004, 287, R12–R20.
205. Cleal, J.K.; Poore, K.R.; Boullin, J.P.; Khan, O.; Chau, R.; Hambidge, O.; Torrens, C.; Newman, J.P.; Poston, L.; Noakes, D.E., et al. Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood. Proc. Natl. Acad. Sci. USA 2007, 104, 9529–9533.
206. Jaquiery, A.L.; Oliver, M.H.; Honeyfield-Ross, M.; Harding, J.E.; Bloomfield, F.H. Periconceptional undernutrition in sheep affects adult phenotype only in males. J. Nutr. Metab. 2012, 2012, 7.
207. Chen, M.; Norman, R.J.; Heilbronn, L.K. Does in vitro fertilisation increase type 2 diabetes and cardiovascular risk? Curr. Diabetes Rev. 2011, 7, 426–432.
208. Eisenberg, E. Long-term outcomes in children born after assisted conception. Semin. Reprod. Med. 2012, 30, 123–130.
209. Hart, R.; Norman, R.J. The longer-term health outcomes for children born as a result of IVF treatment: Part I—General health outcomes. Hum. Reprod. Update 2013, 19, 232–243.
210. Hart, R.; Norman, R.J. The longer-term health outcomes for children born as a result of IVF treatment. Part II—Mental health and development outcomes. Hum. Reprod. Update 2013, 19, 244–250.
211. Sinclair, K.D.; Young, L.E.; Wilmut, I.; McEvoy, T.G. In-utero overgrowth in ruminants following embryo culture: Lessons from mice and a warning to men. Hum. Reprod. 2000, 15, 68–86.
212. Rebecca, C.P.; Susanne, R.D.R.; Patrick, M.B.; Timothy, A.S.; Clive, O.; David, J.B.; Otto, P.B.; Tessa, J.R. Early onset of coronary artery disease after prenatal exposure to the Dutch famine. Am. J. Clin. Nutr. 2006, 84, 322–327.
213. Watkins, A.J.; Lucas, E.S.; Fleming, T.P. Impact of the periconceptional environment on the programming of adult disease. J. Dev. Orig. Health Dis. 2010, 1, 87–95.
214. Taitson, P.F.; Kwong, D.D.; Lima, G.C.D.A.; Coelho, L.S.; Bruce, W.D.; Bernardes, N.D.O. Incidence and anatomy of cardiac malformations in children conceived by assisted reproduction techniques—A review. JBRA Assist. Reprod. 2014, 18, 52–54.
215. Lancaster, P.A. Congenital malformations after in vitro fertilisation. Lancet 1987, 2, 1392–1393.
216. Olson, C.K.; Keppler-Noreuil, K.M.; Romitti, P.A.; Budelier, W.T.; Ryan, G.; Sparks, A.E.; van Voorhis, B.J. In vitro fertilization is associated with an increase in major birth defects. Fertil. Steril. 2005, 84, 1308–1315.
217. Davies, M.J.; Moore, V.M.; Willson, K.J.; van Essen, P.; Priest, K.; Scott, H.; Haan, E.A.; Chan, A. Reproductive technologies and the risk of birth defects. N. Engl. J. Med. 2012, 366, 1803–1813.
218. Hansen, M.; Kurinczuk, J.J.; Bower, C.; Webb, S. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N. Engl. J. Med. 2002, 346, 725–730.
219. Anthony, S.; Buitendijk, S.E.; Dorrepaal, C.A.; Lindner, K.; Braat, D.D.; den Ouden, A.L. Congenital malformations in 4224 children conceived after IVF. Hum. Reprod. 2002, 17, 2089–2095.
220. Klemetti, R.; Gissler, M.; Sevon, T.; Koivurova, S.; Ritvanen, A.; Hemminki, E. Children born after assisted fertilization have an increased rate of major congenital anomalies. Fertil. Steril. 2005, 84, 1300–1307.
221. Wen, S.W.; Leader, A.; White, R.R.; Leveille, M.-C.; Wilkie, V.; Zhou, J.; Walker, M.C. A comprehensive assessment of outcomes in pregnancies conceived by in vitro fertilization/intracytoplasmic sperm injection. Eur. J. Obstet. Gynecol. Reprod. Biol. 2010, 150, 160–165.
222. Mozafari Kermani, R.; Nedaeifard, L.; Nateghi, M.R.; Shahzadeh Fazeli, A.; Ahmadi, E.; Osia, M.A.; Jafarzadehpour, E.; Nouri, S. Congenital anomalies in infants conceived by assisted reproductive techniques. Arch. Iran. Med. 2012, 15, 228–231.
223. Koivurova, S.; Hartikainen, A.L.; Gissler, M.; Hemminki, E.; Sovio, U.; Jarvelin, M.R. Neonatal outcome and congenital malformations in children born after in vitro fertilization. Hum. Reprod. 2002, 17, 1391–1398.
224. Farhangniya, M.; Dortaj Rabori, E.; Mozafari Kermani, R.; Haghdoost, A.A.; Bahrampour, A.; Bagheri, P.; Lancestar, P.A.L.; Ashrafi, M.; Vosough Taqi Dizaj, A.; Gourabi, H., et al. Comparison of congenital abnormalities of infants conceived by assisted reproductive techniques versus infants with natural conception in Tehran. Int. J. Fertil. Steril. 2013, 7, 217–224.
225. Reefhuis, J.; Honein, M.A.; Schieve, L.A.; Correa, A.; Hobbs, C.A.; Rasmussen, S.A. Assisted reproductive technology and major structural birth defects in the United States. Hum. Reprod. 2009, 24, 360–366.
226. Källén, B.; Finnström, O.; Nygren, K.G.; Olausson, P.O. In vitro fertilization (IVF) in Sweden: Risk for congenital malformations after different IVF methods. Birth Defects Res. Part A: Clin. Mol. Teratol. 2005, 73, 162–169.
227. Källén, B.; Finnström, O.; Lindam, A.; Nilsson, E.; Nygren, K.-G.; Otterblad, P.O. Congenital malformations in infants born after in vitro fertilization in Sweden. Birth Defects Res. Part A: Clin. Mol. Teratol. 2010, 88, 137–143.
228. Tararbit, K.; Houyel, L.; Bonnet, D.; de Vigan, C.; Lelong, N.; Goffinet, F.; Khoshnood, B. Risk of congenital heart defects associated with assisted reproductive technologies: A population-based evaluation. Eur. Heart J. 2011, 32, 500–508.
229. Olson, C.K.; Keppler-Noreuil, K.M.; Romitti, P.A.; Budelier, W.T.; Ryan, G.; Sparks, A.E.; van Voorhis, B.J. In vitro fertilization is associated with an increase in major birth defects. Fertil. Steril. 2005, 84, 1308–1315.
230. Davies, M.J.; Moore, V.M.; Willson, K.J.; van Essen, P.; Priest, K.; Scott, H.; Haan, E.A.; Chan, A. Reproductive technologies and the risk of birth defects. N. Engl. J. Med. 2012, 366, 1803–1813.
231. Hansen, M.; Kurinczuk, J.J.; Bower, C.; Webb, S. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N. Engl. J. Med. 2002, 346, 725–730.
232. Anthony, S.; Buitendijk, S.E.; Dorrepaal, C.A.; Lindner, K.; Braat, D.D.; den Ouden, A.L. Congenital malformations in 4224 children conceived after IVF. Hum. Reprod. 2002, 17, 2089–2095.
233. Klemetti, R.; Gissler, M.; Sevon, T.; Koivurova, S.; Ritvanen, A.; Hemminki, E. Children born after assisted fertilization have an increased rate of major congenital anomalies. Fertil. Steril. 2005, 84, 1300–1307.
234. Wen, S.W.; Leader, A.; White, R.R.; Leveille, M.-C.; Wilkie, V.; Zhou, J.; Walker, M.C. A comprehensive assessment of outcomes in pregnancies conceived by in vitro fertilization/intracytoplasmic sperm injection. Eur. J. Obstet. Gynecol. Reprod. Biol. 2010, 150, 160–165.
235. Mozafari Kermani, R.; Nedaeifard, L.; Nateghi, M.R.; Shahzadeh Fazeli, A.; Ahmadi, E.; Osia, M.A.; Jafarzadehpour, E.; Nouri, S. Congenital anomalies in infants conceived by assisted reproductive techniques. Arch. Iran. Med. 2012, 15, 228–231.
236. Koivurova, S.; Hartikainen, A.L.; Gissler, M.; Hemminki, E.; Sovio, U.; Jarvelin, M.R. Neonatal outcome and congenital malformations in children born after in vitro fertilization. Hum. Reprod. 2002, 17, 1391–1398.
237. Farhangniya, M.; Dortaj Rabori, E.; Mozafari Kermani, R.; Haghdoost, A.A.; Bahrampour, A.; Bagheri, P.; Lancestar, P.A.L.; Ashrafi, M.; Vosough Taqi Dizaj, A.; Gourabi, H., et al. Comparison of congenital abnormalities of infants conceived by assisted reproductive techniques versus infants with natural conception in Tehran. Int. J. Fertil. Steril. 2013, 7, 217–224.
238. Reefhuis, J.; Honein, M.A.; Schieve, L.A.; Correa, A.; Hobbs, C.A.; Rasmussen, S.A. Assisted reproductive technology and major structural birth defects in the United States. Hum. Reprod. 2009, 24, 360–366.
239. Källén, B.; Finnström, O.; Nygren, K.G.; Olausson, P.O. In vitro fertilization (IVF) in Sweden: Risk for congenital malformations after different IVF methods. Birth Defects Res. Part A: Clin. Mol. Teratol. 2005, 73, 162–169.
240. Källén, B.; Finnström, O.; Lindam, A.; Nilsson, E.; Nygren, K.-G.; Otterblad, P.O. Congenital malformations in infants born after in vitro fertilization in Sweden. Birth Defects Res. Part A: Clin. Mol. Teratol. 2010, 88, 137–143.
241. Tararbit, K.; Houyel, L.; Bonnet, D.; de Vigan, C.; Lelong, N.; Goffinet, F.; Khoshnood, B. Risk of congenital heart defects associated with assisted reproductive technologies: A population-based evaluation. Eur. Heart J. 2011, 32, 500–508.
242. Tararbit, K.; Lelong, N.; Thieulin, A.-C.; Houyel, L.; Bonnet, D.; Goffinet, F.; Khoshnood, B.; EPICARD Study Group. The risk for four specific congenital heart defects associated with assisted reproductive techniques: A population-based evaluation. Hum. Reprod. 2013, 28, 367–374.
243. Valenzuela-Alcaraz, B.; Crispi, F.; Bijnens, B.; Cruz-Lemini, M.; Creus, M.; Sitges, M.; Bartrons, J.; Civico, S.; Balasch, J.; Gratacos, E. Assisted reproductive technologies are associated with cardiovascular remodeling in utero that persists postnatally. Circulation 2013, 128, 1442–1450.
244. Ceelen, M.; van Weissenbruch, M.M.; Vermeiden, J.P.W.; van Leeuwen, F.E.; Delemarre-van de Waal, H.A. Cardiometabolic differences in children born after in vitro fertilization: follow-up study. J. Clin. Endocrinol. Metab. 2008, 93, 1682–1688.
245. Ceelen, M.; van Weissenbruch, M.M.; Prein, J.; Smit, J.J.; Vermeiden, J.P.; Spreeuwenberg, M.; van Leeuwen, F.E.; Delemarre-van de Waal, H.A. Growth during infancy and early childhood in relation to blood pressure and body fat measures at age 8–18 years of IVF children and spontaneously conceived controls born to subfertile parents. Hum. Reprod. 2009, 24, 2788–2795.
246. Sinaiko, A.R.; Donahue, R.P.; Jacobs, D.R.; Prineas, R.J. Relation of weight and rate of increase in weight during childhood and adolescence to body size, blood pressure, fasting insulin, and lipids in young adults: the minneapolis children’s blood pressure study. Circulation 1999, 99, 1471–1476.
247. Law, C.M.; Shiell, A.W.; Newsome, C.A.; Syddall, H.E.; Shinebourne, E.A.; Fayers, P.M.; Martyn, C.N.; de Swiet, M. Fetal, infant, and childhood growth and adult blood pressure: a longitudinal study from birth to 22 years of age. Circulation 2002, 105, 1088–1092.
248. Sakka, S.D.; Loutradis, D.; Kanaka-Gantenbein, C.; Margeli, A.; Papastamataki, M.; Papassotiriou, I.; Chrousos, G.P. Absence of insulin resistance and low-grade inflammation despite early metabolic syndrome manifestations in children born after in vitro fertilization. Fertil. Steril. 2010, 94, 1693–1699.
249. Scherrer, U.; Rimoldi, S.F.; Rexhaj, E.; Stuber, T.; Duplain, H.; Garcin, S.; de Marchi, S.F.; Nicod, P.; Germond, M.; Allemann, Y., et al. Systemic and pulmonary vascular dysfunction in children conceived by assisted reproductive technologies. Circulation 2012, 125, 1890–1896.
250. Charakida, M.; Deanfield, J.E.; Halcox, J.P. Childhood origins of arterial disease. Curr. Opin. Pediatr. 2007, 19, 538–545.
251. Urbina, E.M.; Williams, R.V.; Alpert, B.S.; Collins, R.T.; Daniels, S.R.; Hayman, L.; Jacobson, M.; Mahoney, L.; Mietus-Snyder, M.; Rocchini, A., et al. Noninvasive assessment of subclinical atherosclerosis in children and adolescents: recommendations for standard assessment for clinical research: A scientific statement from the american heart association. Hypertension 2009, 54, 919–950.
252. Bonetti, P.O.; Lerman, L.O.; Lerman, A. Endothelial dysfunction a marker of atherosclerotic risk. Arterioscler. Thromb. Vasc. Biol. 2003, 23, 168–175.
253. Sitia, S.; Tomasoni, L.; Atzeni, F.; Ambrosio, G.; Cordiano, C.; Catapano, A.; Tramontana, S.; Perticone, F.; Naccarato, P.; Camici, P. From endothelial dysfunction to atherosclerosis. Autoimmun. Rev. 2010, 9, 830–834.
254. Van Popele, N.M.; Grobbee, D.E.; Bots, M.L.; Asmar, R.; Topouchian, J.; Reneman, R.S.; Hoeks, A.P.; van der Kuip, D.A.; Hofman, A.; Witteman, J.C. Association between arterial stiffness and atherosclerosis The Rotterdam Study. Stroke 2001, 32, 454–460.
255. Bots, M.L.; Dijk, J.M.; Oren, A.; Grobbee, D.E. Carotid intima-media thickness, arterial stiffness and risk of cardiovascular disease: Current evidence. J. Hypertens. 2002, 20, 2317–2325.
256. Simons, P.C.; Algra, A.; Bots, M.L.; Grobbee, D.E.; van der Graaf, Y. Common carotid intima-media thickness and arterial stiffness: Indicators of cardiovascular risk in high-risk patients. The SMART Study (Second Manifestations of ARTerial disease). Circulation 1999, 100, 951–957.
257. Rooke, J.A.; McEvoy, T.G.; Ashworth, C.J.; Robinson, J.J.; Wilmut, I.; Young, L.E.; Sinclair, K.D. Ovine fetal development is more sensitive to perturbation by the presence of serum in embryo culture before rather than after compaction. Theriogenology 2007, 67, 639–647.
258. Powell, K.; Rooke, J.A.; McEvoy, T.G.; Ashworth, C.J.; Robinson, J.J.; Wilmut, I.; Young, L.E.; Sinclair, K.D. Zygote donor nitrogen metabolism and in vitro embryo culture perturbs in utero development and IGF2R expression in ovine fetal tissues. Theriogenology 2006, 66, 1901–1912.
259. Farin, P.W.; Farin, C.E. Transfer of bovine embryos produced in vivo or in vitro: Survival and fetal development. Biol. Reprod. 1995, 52, 676–682.
260. Van Wagtendonk-de Leeuw, A.M.; Mullaart, E.; de Roos, A.P.W.; Merton, J.S.; den Daas, J.H.G.; Kemp, B.; de Ruigh, L. Effects of different reproduction techniques: AI, moet or IVP, on health and welfare of bovine offspring. Theriogenology 2000, 53, 575–597.
261. McEvoy, T.G.; Sinclair, K.D.; Broadbent, P.J.; Goodhand, K.L.; Robinson, J.J. Post-natal growth and development of Simmental calves derived from in vivo or in vitro embryos. Reprod. Fertil. Dev. 1998, 10, 459–464.
262. Rexhaj, E.; Paoloni-Giacobino, A.; Rimoldi, S.F.; Fuster, D.G.; Anderegg, M.; Somm, E.; Bouillet, E.; Allemann, Y.; Sartori, C.; Scherrer, U. Mice generated by in vitro fertilization exhibit vascular dysfunction and shortened life span. J. Clin. Investig. 2013, 123, 5052–5060.
263. Young, L.E.; Sinclair, K.D.; Wilmut, I. Large offspring syndrome in cattle and sheep. Rev. Reprod. 1998, 3, 155–163.
264. Farin, P.W.; Piedrahita, J.A.; Farin, C.E. Errors in development of fetuses and placentas from in vitro-produced bovine embryos. Theriogenology 2006, 65, 178–191.
265. McEvoy, T.G.; Robinson, J.J.; Sinclair, K.D. Developmental consequences of embryo and cell manipulation in mice and farm animals. Reproduction 2001, 122, 507–518.
266. Wang, K.C.W.; Botting, K.J.; Padhee, M.; Zhang, S.; McMillen, I.C.; Suter, C.M.; Brooks, D.A.; Morrison, J.L. Early origins of heart disease: Low birth weight and the role of the insulin-like growth factor system in cardiac hypertrophy. Clin. Exp. Pharmacol. Physiol. 2012, 39, 958–964.
267. Wang, K.C.; Zhang, L.; McMillen, I.C.; Botting, K.J.; Duffield, J.A.; Zhang, S.; Suter, C.M.; Brooks, D.A.; Morrison, J.L. Fetal growth restriction and the programming of heart growth and cardiac insulin-like growth factor 2 expression in the lamb. J. Physiol. 2011, 589, 4709–4722.
268. Vinci, M.; Polvani, G.; Pesce, M. Epigenetic programming and risk: The birthplace of cardiovascular disease? Stem Cell Rev. Rep. 2013, 9, 241–253.
269. Heijmans, B.T.; Tobi, E.W.; Stein, A.D.; Putter, H.; Blauw, G.J.; Susser, E.S.; Slagboom, P.E.; Lumey, L.H. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc. Natl. Acad. Sci. USA 2008, 105, 17046–17049.
270. Tobi, E.W.; Lumey, L.H.; Talens, R.P.; Kremer, D.; Putter, H.; Stein, A.D.; Slagboom, P.E.; Heijmans, B.T. DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum. Mol. Genet. 2009, 18, 4046–4053.
271. Roseboom, T.; de Rooij, S.; Painter, R. The Dutch famine and its long-term consequences for adult health. Early Hum. Dev. 2006, 82, 485–491.
272. Sinclair, K.D.; Allegrucci, C.; Singh, R.; Gardner, D.S.; Sebastian, S.; Bispham, J.; Thurston, A.; Huntley, J.F.; Rees, W.D.; Maloney, C.A., et al. DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc. Natl. Acad. Sci. USA 2007, 104, 19351–19356.
273. Celermajer, D.S. Manipulating nature: Might there be a cardiovascular price to pay for the miracle of assisted conception? Circulation 2012, 125, 1832–1834.
274. Horsthemke, B.; Ludwig, M. Assisted reproduction: The epigenetic perspective. Hum. Reprod. Update 2005, 11, 473–482.
275. DeBaun, M.R.; Niemitz, E.L.; Feinberg, A.P. Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19. Am. J. Hum. Genet. 2003, 72, 156–160.
276. Gicquel, C.; Gaston, V.; Mandelbaum, J.; Siffroi, J.P.; Flahault, A.; le Bouc, Y. In vitro fertilization may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCN1OT gene. Am. J. Hum. Genet. 2003, 72, 1338–1341.
277. Maher, E.R.; Brueton, L.A.; Bowdin, S.C.; Luharia, A.; Cooper, W.; Cole, T.R.; Macdonald, F.; Sampson, J.R.; Barratt, C.L.; Reik, W.; Hawkins, M.M. Beckwith-Wiedemann syndrome and assisted reproduction technology (ART). J. Med. Genet. 2003, 40, 62–64.
278. Halliday, J.; Oke, K.; Breheny, S.; Algar, E.; David, J.A. Beckwith-Wiedemann syndrome and IVF: A case-control study. Am. J. Hum. Genet. 2004, 75, 526–528.
279. Lim, D.; Bowdin, S.C.; Tee, L.; Kirby, G.A.; Blair, E.; Fryer, A.; Lam, W.; Oley, C.; Cole, T.; Brueton, L.A., et al. Clinical and molecular genetic features of Beckwith-Wiedemann syndrome associated with assisted reproductive technologies. Hum. Reprod. 2009, 24, 741–747.
280. Rossignol, S.; Steunou, V.; Chalas, C.; Kerjean, A.; Rigolet, M.; Viegas-Pequignot, E.; Jouannet, P.; le Bouc, Y.; Gicquel, C. The epigenetic imprinting defect of patients with Beckwith-Wiedemann syndrome born after assisted reproductive technology is not restricted to the 11p15 region. J. Med. Genet. 2006, 43, 902–907.
281. Moll, A.C.; Imhof, S.M.; Cruysberg, J.R.; Schouten-van Meeteren, A.Y.; Boers, M.; van Leeuwen, F.E. Incidence of retinoblastoma in children born after in vitro fertilisation. Lancet 2003, 361, 309–310.
282. Mantikou, E.; Youssef, M.A.F.M.; van Wely, M.; van der Veen, F.; Al-Inany, H.G.; Repping, S.; Mastenbroek, S. Embryo culture media and IVF/ICSI success rates: A systematic review. Hum. Reprod. Update 2013, 19, 210–220.
283. Bromer, J.G.; Sakkas, D.; Seli, E. Metabolomic profiling of embryo culture media to predict IVF outcome. Expert Rev. Obstet. Gynecol. 2008, 3, 441–447.
284. Katari, S.; Turan, N.; Bibikova, M.; Erinle, O.; Chalian, R.; Foster, M.; Gaughan, J.P.; Coutifaris, C.; Sapienza, C. DNA methylation and gene expression differences in children conceived in vitro or in vivo. Hum. Mol. Genet. 2009, 18, 3769–3778.
285. Lui, J.C.; Finkielstain, G.P.; Barnes, K.M.; Baron, J. An imprinted gene network that controls mammalian somatic growth is down-regulated during postnatal growth deceleration in multiple organs. Am. J. Physiol.Regul. Integr. Comp. Physiol. 2008, 295, R189–R196.
286. Olofsson, L.E.; Orho-Melander, M.; William-Olsson, L.; Sjoholm, K.; Sjostrom, L.; Groop, L.; Carlsson, B.; Carlsson, L.M.; Olsson, B. CCAAT/enhancer binding protein alpha (C/EBPalpha) in adipose tissue regulates genes in lipid and glucose metabolism and a genetic variation in C/EBPalpha is associated with serum levels of triglycerides. J. Clin. Endocrinol. Metab. 2008, 93, 4880–4886.
287. Mzhavia, N.; Yu, S.; Ikeda, S.; Chu, T.T.; Goldberg, I.; Dansky, H.M. Neuronatin: A new inflammation gene expressed on the aortic endothelium of diabetic mice. Diabetes 2008, 57, 2774–2783.
288. Wang, P.; Smit, E.; Brouwers, M.C.G.J.; Goossens, G.H.; van der Kallen, C.J.H.; van Greevenbroek, M.M.J.; Mariman, E.C.M. Plasma pigment epithelium-derived factor is positively associated with obesity in Caucasian subjects, in particular with the visceral fat depot. Eur. J. Endocrinol. 2008, 159, 713–718.
289. Linke, M.; May, A.; Reifenberg, K.; Haaf, T.; Zechner, U. The impact of ovarian stimulation on the expression of candidate reprogramming genes in mouse preimplantation embryos. Cytogenet. Genome Res. 2013, 139, 71–79.
290. Fauque, P. Ovulation induction and epigenetic anomalies. Fertil. Steril. 2013, 99, 616–623.
291. Geuns, E.; Hilven, P.; van Steirteghem, A.; Liebaers, I.; de Rycke, M. Methylation analysis of KvDMR1 in human oocytes. J. Med. Genet. 2007, 44, 144–147.
292. Sato, C.; Shimada, M.; Mori, T.; Kumasako, Y.; Otsu, E.; Watanabe, H.; Utsunomiya, T. Assessment of human oocyte developmental competence by cumulus cell morphology and circulating hormone profile. Reprod. BioMed. Online 2007, 14, 49–56.
293. Shi, W.; Haaf, T. Aberrant methylation patterns at the two-cell stage as an indicator of early developmental failure. Mol. Reprod. Dev. 2002, 63, 329–334.
294. Market-Velker, B.A.; Zhang, L.; Magri, L.S.; Bonvissuto, A.C.; Mann, M.R.W. Dual effects of superovulation: Loss of maternal and paternal imprinted methylation in a dose-dependent manner. Hum. Mol. Genet. 2010, 19, 36–51.
295. Laprise, S.L. Implications of epigenetics and genomic imprinting in assisted reproductive technologies. Mol. Reprod. Dev. 2009, 76, 1006–1018.
296. Paoloni-Giacobino, A.; Chaillet, J.R. Genomic imprinting and assisted reproduction. Reprod. Health 2004, 1, 6–12.
297. Li, T.; Vu, T.H.; Ulaner, G.A.; Littman, E.; Ling, J.-Q.; Chen, H.-L.; Hu, J.-F.; Behr, B.; Giudice, L.; Hoffman, A.R. IVF results in de novo DNA methylation and histone methylation at an Igf2-H19 imprinting epigenetic switch. Mol. Hum. Reprod. 2005, 11, 631–640.
298. Doherty, A.S.; Mann, M.R.; Tremblay, K.D.; Bartolomei, M.S.; Schultz, R.M. Differential effects of culture on imprinted H19 expression in the preimplantation mouse embryo. Biol. Reprod. 2000, 62, 1526–1535.
299. Mann, M.R.; Lee, S.S.; Doherty, A.S.; Verona, R.I.; Nolen, L.D.; Schultz, R.M.; Bartolomei, M.S. Selective loss of imprinting in the placenta following preimplantation development in culture. Development 2004, 131, 3727–3735.
300. Wolff, G.L.; Kodell, R.L.; Moore, S.R.; Cooney, C.A. Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. FASEB J. 1998, 12, 949–957.
301. Armant, D.R. Blastocysts don’t go it alone. Extrinsic signals fine-tune the intrinsic developmental program of trophoblast cells. Dev. Biol. 2005, 280, 260–280.
302. Saito, S. Cytokine cross-talk between mother and the embryo/placenta. J. Reprod. Immunol. 2001, 52, 15–33.
303. Burke, A.C.; Nelson, C.E.; Morgan, B.A.; Tabin, C. Hox genes and the evolution of vertebrate axial morphology. Development 1995, 121, 333–346.
304. Boerjan, M.L.; den Daas, J.H.G.; Dieleman, S.J. Embryonic origins of health: Long term effects of IVF in human and livestock. Theriogenology 2000, 53, 537–547.
305. Van Soom, A.; Boerjan, M.L.; Bols, P.E.; Vanroose, G.; Lein, A.; Coryn, M.; de Kruif, A. Timing of compaction and inner cell allocation in bovine embryos produced in vivo after superovulation. Biol. Reprod. 1997, 57, 1041–1049.
306. Van Soom, A.; Boerjan, M.; Ysebaert, M.-T.; de Kruif, A. Cell allocation to the inner cell mass and the trophectoderm in bovine embryos cultured in two different media. Mol. Reprod. Dev. 1996, 45, 171–182.
307. Olson, E.N.; Schneider, M.D. Sizing up the heart: Development redux in disease. Genes Dev. 2003, 17, 1937–1956.
308. Van Montfoort, A.P.; Hanssen, L.L.; de Sutter, P.; Viville, S.; Geraedts, J.P.; de Boer, P. Assisted reproduction treatment and epigenetic inheritance. Hum. Reprod. Update 2012, 18, 171–197.