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Volumn 74, Issue 9, 2007, Pages 1149-1156

Suboptimal in vitro culture conditions: An epigenetic origin of long-term health effects

Author keywords

In vitro culture; Long term effect; Reprogramming

Indexed keywords

DNA;

EID: 34547874966     PISSN: 1040452X     EISSN: 10982795     Source Type: Journal    
DOI: 10.1002/mrd.20746     Document Type: Article
Times cited : (74)

References (70)
  • 1
    • 20344385787 scopus 로고    scopus 로고
    • Epigenetic transgenerational actions of endocrine disrupters and male fertility
    • Anway MD, Cupp AS, Uzumcu M, Skinner MK. 2005. Epigenetic transgenerational actions of endocrine disrupters and male fertility. Science 308:1466-1469.
    • (2005) Science , vol.308 , pp. 1466-1469
    • Anway, M.D.1    Cupp, A.S.2    Uzumcu, M.3    Skinner, M.K.4
  • 2
    • 23844547591 scopus 로고    scopus 로고
    • Epigenetic deregulation of genomic imprinting in human disorders and following assisted reproduction
    • Arnaud P, Feil R. 2005. Epigenetic deregulation of genomic imprinting in human disorders and following assisted reproduction. Birth Defects Res C Embryo Today 75:81-97.
    • (2005) Birth Defects Res C Embryo Today , vol.75 , pp. 81-97
    • Arnaud, P.1    Feil, R.2
  • 3
    • 0036962394 scopus 로고    scopus 로고
    • Fundamental features of chromatin structure
    • Beaujean N. 2002. Fundamental features of chromatin structure. Cloning Stem Cells 4:355-361.
    • (2002) Cloning Stem Cells , vol.4 , pp. 355-361
    • Beaujean, N.1
  • 5
    • 0033753779 scopus 로고    scopus 로고
    • The DNA methyltransferases of mammals
    • Bestor TH. 2000. The DNA methyltransferases of mammals. Hum Mol Genet 9:2395-2402.
    • (2000) Hum Mol Genet , vol.9 , pp. 2395-2402
    • Bestor, T.H.1
  • 6
    • 15244353967 scopus 로고    scopus 로고
    • X-inactivation profile reveals extensive variability in X-linked gene expression in females
    • Carrel L, Willard HF. 2005. X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature 434:400-404.
    • (2005) Nature , vol.434 , pp. 400-404
    • Carrel, L.1    Willard, H.F.2
  • 7
    • 33644872629 scopus 로고    scopus 로고
    • Comparative birth weights of singletons born after assisted reproduction and natural conception in previously infertile women
    • De Geyter C, De Geyter M, Steimann S, Zhang H, Holzgreve W. 2006. Comparative birth weights of singletons born after assisted reproduction and natural conception in previously infertile women. Hum Reprod 21:705-712.
    • (2006) Hum Reprod , vol.21 , pp. 705-712
    • De Geyter, C.1    De Geyter, M.2    Steimann, S.3    Zhang, H.4    Holzgreve, W.5
  • 8
    • 0035838330 scopus 로고    scopus 로고
    • Genomic imprinting: Mother maintains methylation marks
    • Dean W, Ferguson-Smith A. 2001. Genomic imprinting: Mother maintains methylation marks. Curr Biol 11:R527-530.
    • (2001) Curr Biol , vol.11
    • Dean, W.1    Ferguson-Smith, A.2
  • 9
    • 0037222510 scopus 로고    scopus 로고
    • Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19
    • DeBaun MR, Niemitz EL, Feinberg AP. 2003. Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19. Am J Hum Genet 72:156-160.
    • (2003) Am J Hum Genet , vol.72 , pp. 156-160
    • DeBaun, M.R.1    Niemitz, E.L.2    Feinberg, A.P.3
  • 11
    • 0035190207 scopus 로고    scopus 로고
    • Influence of in vitro systems on embryo survival and fetal development in cattle
    • Farin PW, Crosier AE, Farin CE. 2001. Influence of in vitro systems on embryo survival and fetal development in cattle. Theriogenology 55:151-170.
    • (2001) Theriogenology , vol.55 , pp. 151-170
    • Farin, P.W.1    Crosier, A.E.2    Farin, C.E.3
  • 13
    • 33644966523 scopus 로고    scopus 로고
    • Intrauterine programming of physiological systems: Causes and consequences
    • Fowden AL, Giussani DA, Forhead AJ. 2006. Intrauterine programming of physiological systems: Causes and consequences. Physiology 21:29-37.
    • (2006) Physiology , vol.21 , pp. 29-37
    • Fowden, A.L.1    Giussani, D.A.2    Forhead, A.J.3
  • 14
    • 4544366928 scopus 로고    scopus 로고
    • Living with the past: Evolution, development, and patterns of disease
    • Gluckman PD, Hanson MA. 2004. Living with the past: Evolution, development, and patterns of disease. Science 305:1733-1736.
    • (2004) Science , vol.305 , pp. 1733-1736
    • Gluckman, P.D.1    Hanson, M.A.2
  • 15
    • 0037939678 scopus 로고    scopus 로고
    • Rare congenital disorders, imprinted genes, and assisted reproductive technology
    • Gosden R, Trasler J, Lucifero D, Faddy M. 2003. Rare congenital disorders, imprinted genes, and assisted reproductive technology. Lancet 361:1975-1977.
    • (2003) Lancet , vol.361 , pp. 1975-1977
    • Gosden, R.1    Trasler, J.2    Lucifero, D.3    Faddy, M.4
  • 16
    • 0024365892 scopus 로고
    • Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma
    • Greger V, Passarge E, Hopping W, Messmer E, Horsthemke B. 1989. Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum Genet 83:155-158.
    • (1989) Hum Genet , vol.83 , pp. 155-158
    • Greger, V.1    Passarge, E.2    Hopping, W.3    Messmer, E.4    Horsthemke, B.5
  • 17
    • 0343503028 scopus 로고    scopus 로고
    • Differential expression of two genes located on the X chromosome between male and female in vitro-produced bovine embryos at the blastocyst stage
    • Gutierrez-Adan A, Oter M, Martinez-Madrid B, Pintado B, De La Fuente J. 2000. Differential expression of two genes located on the X chromosome between male and female in vitro-produced bovine embryos at the blastocyst stage. Mol Reprod Dev 55:146-151.
    • (2000) Mol Reprod Dev , vol.55 , pp. 146-151
    • Gutierrez-Adan, A.1    Oter, M.2    Martinez-Madrid, B.3    Pintado, B.4    De La Fuente, J.5
  • 19
    • 0037035126 scopus 로고    scopus 로고
    • The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization
    • Hansen M, Kurinczuk JJ, Bower C, Webb S. 2002. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med 346:725-730.
    • (2002) N Engl J Med , vol.346 , pp. 725-730
    • Hansen, M.1    Kurinczuk, J.J.2    Bower, C.3    Webb, S.4
  • 20
    • 14044279292 scopus 로고    scopus 로고
    • Assisted reproductive technologies and the risk of birth defects - a systematic review
    • Hansen M, Bower C, Milne E, de Klerk N, Kurinczuk JJ. 2005. Assisted reproductive technologies and the risk of birth defects - a systematic review. Hum Reprod 20:328-338.
    • (2005) Hum Reprod , vol.20 , pp. 328-338
    • Hansen, M.1    Bower, C.2    Milne, E.3    de Klerk, N.4    Kurinczuk, J.J.5
  • 21
    • 0141795506 scopus 로고    scopus 로고
    • Mouse preimplantation embryos developed from oocytes injected with round spermatids or spermatozoa have similar but distinct patterns of early messenger RNA expression
    • Hayashi S, Yang J, Christenson L, Yanagimachi R, Hecht NB. 2003. Mouse preimplantation embryos developed from oocytes injected with round spermatids or spermatozoa have similar but distinct patterns of early messenger RNA expression. Biol Reprod 69:1170-1176.
    • (2003) Biol Reprod , vol.69 , pp. 1170-1176
    • Hayashi, S.1    Yang, J.2    Christenson, L.3    Yanagimachi, R.4    Hecht, N.B.5
  • 22
    • 26444564294 scopus 로고    scopus 로고
    • Assisted reproduction: The epigenetic perspective
    • Horsthemke B, Ludwig M. 2005. Assisted reproduction: The epigenetic perspective. Hum Reprod Update 11:473-482.
    • (2005) Hum Reprod Update , vol.11 , pp. 473-482
    • Horsthemke, B.1    Ludwig, M.2
  • 23
    • 0347357614 scopus 로고    scopus 로고
    • Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos
    • Huynh KD, Lee JT. 2003. Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos. Nature 426:857-862.
    • (2003) Nature , vol.426 , pp. 857-862
    • Huynh, K.D.1    Lee, J.T.2
  • 24
    • 0037304946 scopus 로고    scopus 로고
    • Obesity - a chronic health problem in cloned mice?
    • Inui A. 2003. Obesity - a chronic health problem in cloned mice? Trends Pharmacol Sci 24:77-80.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 77-80
    • Inui, A.1
  • 25
    • 0034255591 scopus 로고    scopus 로고
    • Imprinted genes, cognition and behaviour
    • Isles AR, Wilkinson LS. 2000. Imprinted genes, cognition and behaviour. Trends Cogn Sci 4:309-318.
    • (2000) Trends Cogn Sci , vol.4 , pp. 309-318
    • Isles, A.R.1    Wilkinson, L.S.2
  • 26
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • Jaenisch R, Bird A. 2003. Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals. Nat Genet 33:245-254.
    • (2003) Nat Genet , vol.33 , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 28
    • 15044355285 scopus 로고    scopus 로고
    • The problematic in-vitro embryo in the age of epigenetics
    • Johnson MH. 2005. The problematic in-vitro embryo in the age of epigenetics. Reprod Biomed Online 10:88-96.
    • (2005) Reprod Biomed Online , vol.10 , pp. 88-96
    • Johnson, M.H.1
  • 29
    • 0035839057 scopus 로고    scopus 로고
    • The role of DNA methylation in mammalian epigenetics
    • Jones PA, Takai D. 2001. The role of DNA methylation in mammalian epigenetics. Science 293:1068-1070.
    • (2001) Science , vol.293 , pp. 1068-1070
    • Jones, P.A.1    Takai, D.2
  • 30
    • 0035116489 scopus 로고    scopus 로고
    • Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes
    • Khosla S, Dean W, Brown D, Reik W, Feil R. 2001. Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes. Biol Reprod 64:918-926.
    • (2001) Biol Reprod , vol.64 , pp. 918-926
    • Khosla, S.1    Dean, W.2    Brown, D.3    Reik, W.4    Feil, R.5
  • 31
  • 33
    • 0024254164 scopus 로고
    • The intracisternal A-particle gene family: Structure and functional aspects
    • Kuff EL, Lueders KK. 1988. The intracisternal A-particle gene family: Structure and functional aspects. Adv Cancer Res 51:183-276.
    • (1988) Adv Cancer Res , vol.51 , pp. 183-276
    • Kuff, E.L.1    Lueders, K.K.2
  • 34
    • 0033756720 scopus 로고    scopus 로고
    • Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension
    • Kwong WY, Wild AE, Roberts P, Willis AC, Fleming TP. 2000. Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension. Development 127:4195-4202.
    • (2000) Development , vol.127 , pp. 4195-4202
    • Kwong, W.Y.1    Wild, A.E.2    Roberts, P.3    Willis, A.C.4    Fleming, T.P.5
  • 35
    • 15844366255 scopus 로고    scopus 로고
    • Understanding cellular disruptions during early embryo development that perturb viability and fetal development
    • Lane M, Gardner DK. 2005. Understanding cellular disruptions during early embryo development that perturb viability and fetal development. Reprod Fertil Dev 17:371-378.
    • (2005) Reprod Fertil Dev , vol.17 , pp. 371-378
    • Lane, M.1    Gardner, D.K.2
  • 36
    • 0037298161 scopus 로고    scopus 로고
    • Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse
    • Lane N, Dean W, Erhardt S, Hajkova P, Surani A, Walter J, Reik W. 2003. Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse. Genesis 35:88-93.
    • (2003) Genesis , vol.35 , pp. 88-93
    • Lane, N.1    Dean, W.2    Erhardt, S.3    Hajkova, P.4    Surani, A.5    Walter, J.6    Reik, W.7
  • 38
    • 0036733675 scopus 로고    scopus 로고
    • Chromatin modification and epigenetic reprogramming in mammalian development
    • Li E. 2002. Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet 3:662-673.
    • (2002) Nat Rev Genet , vol.3 , pp. 662-673
    • Li, E.1
  • 40
    • 0347531606 scopus 로고    scopus 로고
    • Effect of culture environment on embryo quality and gene expression-experience from animal studies
    • Lonergan P, Rizos D, Gutierrez-Adan A, Fair T, Boland MP. 2003. Effect of culture environment on embryo quality and gene expression-experience from animal studies. Reprod Biomed Online 7:657-663.
    • (2003) Reprod Biomed Online , vol.7 , pp. 657-663
    • Lonergan, P.1    Rizos, D.2    Gutierrez-Adan, A.3    Fair, T.4    Boland, M.P.5
  • 41
    • 0346777377 scopus 로고    scopus 로고
    • Epigenetic risks related to assisted reproductive technologies: Epigenetics, imprinting, ART and icebergs?
    • Maher ER, Afnan M, Barratt CL. 2003. Epigenetic risks related to assisted reproductive technologies: Epigenetics, imprinting, ART and icebergs? Hum Reprod 18:2508-2511.
    • (2003) Hum Reprod , vol.18 , pp. 2508-2511
    • Maher, E.R.1    Afnan, M.2    Barratt, C.L.3
  • 45
    • 0033005827 scopus 로고    scopus 로고
    • Angelman syndrome resulting from UBE3A mutations in 14 patients from eight families: Clinical manifestations and genetic counselling
    • Moncla A, Malzac P, Livet MO, Voelckel MA, Mancini J, Delaroziere JC, Philip N, Mattei JF. 1999. Angelman syndrome resulting from UBE3A mutations in 14 patients from eight families: Clinical manifestations and genetic counselling. J Med Genet 36:554-560.
    • (1999) J Med Genet , vol.36 , pp. 554-560
    • Moncla, A.1    Malzac, P.2    Livet, M.O.3    Voelckel, M.A.4    Mancini, J.5    Delaroziere, J.C.6    Philip, N.7    Mattei, J.F.8
  • 46
    • 27844503601 scopus 로고    scopus 로고
    • Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice
    • Okamoto I, Arnaud D, Le Baccon P, Otte AP, Disteche CM, Avner P, Heard E. 2005. Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice. Nature 438:369-373.
    • (2005) Nature , vol.438 , pp. 369-373
    • Okamoto, I.1    Arnaud, D.2    Le Baccon, P.3    Otte, A.P.4    Disteche, C.M.5    Avner, P.6    Heard, E.7
  • 48
    • 27144507445 scopus 로고    scopus 로고
    • Differential sensitivity of male and female mouse embryos to oxidative induced heat-stress is mediated by glucose-6-phosphate dehydrogenase gene expression
    • Perez-Crespo M, Ramirez MA, Fernandez-Gonzalez R, Rizos D, Lonergan P, Pintado B, Gutierrez-Adan A. 2005. Differential sensitivity of male and female mouse embryos to oxidative induced heat-stress is mediated by glucose-6-phosphate dehydrogenase gene expression. Mol Reprod Dev 72:502-510.
    • (2005) Mol Reprod Dev , vol.72 , pp. 502-510
    • Perez-Crespo, M.1    Ramirez, M.A.2    Fernandez-Gonzalez, R.3    Rizos, D.4    Lonergan, P.5    Pintado, B.6    Gutierrez-Adan, A.7
  • 49
    • 0042572938 scopus 로고    scopus 로고
    • Transgenerational epigenetic inheri-tance
    • Rakyan V, Whitelaw E. 2003. Transgenerational epigenetic inheri-tance. Curr Biol 13:R6.
    • (2003) Curr Biol , vol.13
    • Rakyan, V.1    Whitelaw, E.2
  • 50
    • 0037418193 scopus 로고    scopus 로고
    • Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission
    • Rakyan VK, Chong S, Champ ME, Cuthbert PC, Morgan HD, Luu KV, Whitelaw E. 2003. Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc Natl Acad Sci USA 100:2538-2543.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2538-2543
    • Rakyan, V.K.1    Chong, S.2    Champ, M.E.3    Cuthbert, P.C.4    Morgan, H.D.5    Luu, K.V.6    Whitelaw, E.7
  • 51
    • 0019318994 scopus 로고
    • DNA methylation and gene function
    • Razin A, Riggs AD. 1980. DNA methylation and gene function. Science 210:604-610.
    • (1980) Science , vol.210 , pp. 604-610
    • Razin, A.1    Riggs, A.D.2
  • 52
    • 0035839126 scopus 로고    scopus 로고
    • Epigenetic reprogramming in mammalian development
    • Reik W, Dean W, Walter J. 2001. Epigenetic reprogramming in mammalian development. Science 293:1089-1093.
    • (2001) Science , vol.293 , pp. 1089-1093
    • Reik, W.1    Dean, W.2    Walter, J.3
  • 53
    • 23844465171 scopus 로고    scopus 로고
    • Cloning and assisted reproductive techniques: Influence on early development and adult phenotype
    • Sakai RR, Tamashiro KL, Yamazaki Y, Yanagimachi R. 2005. Cloning and assisted reproductive techniques: Influence on early development and adult phenotype. Birth Defects Res C Embryo Today 75:151-162.
    • (2005) Birth Defects Res C Embryo Today , vol.75 , pp. 151-162
    • Sakai, R.R.1    Tamashiro, K.L.2    Yamazaki, Y.3    Yanagimachi, R.4
  • 54
    • 3042854695 scopus 로고    scopus 로고
    • Epigenetic reprogramming during early development in mammals
    • Santos F, Dean W. 2004. Epigenetic reprogramming during early development in mammals. Reproduction 127:643-651.
    • (2004) Reproduction , vol.127 , pp. 643-651
    • Santos, F.1    Dean, W.2
  • 55
    • 0037035121 scopus 로고    scopus 로고
    • Low and very low birth weight in infants conceived with use of assisted reproductive technology
    • Schieve LA, Meikle SF, Ferre C, Peterson HB, Jeng G, Wilcox LS. 2002. Low and very low birth weight in infants conceived with use of assisted reproductive technology. N Engl J Med 346:731-737.
    • (2002) N Engl J Med , vol.346 , pp. 731-737
    • Schieve, L.A.1    Meikle, S.F.2    Ferre, C.3    Peterson, H.B.4    Jeng, G.5    Wilcox, L.S.6
  • 56
    • 14344252402 scopus 로고    scopus 로고
    • Retrotransposons and regulatory suites
    • Shapiro JA. 2005. Retrotransposons and regulatory suites. Bioessays 27:122-125.
    • (2005) Bioessays , vol.27 , pp. 122-125
    • Shapiro, J.A.1
  • 58
    • 0034519713 scopus 로고    scopus 로고
    • In-utero overgrowth in ruminants following embryo culture: Lessons from mice and a warning to men
    • Sinclair KD, Young LE, Wilmut I, McEvoy TG. 2000. In-utero overgrowth in ruminants following embryo culture: Lessons from mice and a warning to men. Hum Reprod 15:68-86.
    • (2000) Hum Reprod , vol.15 , pp. 68-86
    • Sinclair, K.D.1    Young, L.E.2    Wilmut, I.3    McEvoy, T.G.4
  • 59
    • 17744390600 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor alleviates adverse consequences of embryo culture on fetal growth trajectory and placental morphogenesis
    • Sjoblom C, Roberts CT, Wikland M, Robertson SA. 2005. Granulocyte-macrophage colony-stimulating factor alleviates adverse consequences of embryo culture on fetal growth trajectory and placental morphogenesis. Endocrinology 146:2142-2153.
    • (2005) Endocrinology , vol.146 , pp. 2142-2153
    • Sjoblom, C.1    Roberts, C.T.2    Wikland, M.3    Robertson, S.A.4
  • 60
    • 5444264003 scopus 로고    scopus 로고
    • Biological control through regulated transcriptional coactivators
    • Spiegelman BM, Heinrich R. 2004. Biological control through regulated transcriptional coactivators. Cell 119:157-167.
    • (2004) Cell , vol.119 , pp. 157-167
    • Spiegelman, B.M.1    Heinrich, R.2
  • 61
    • 0346025685 scopus 로고    scopus 로고
    • Chemically defined media and the culture of mammalian preimplantation embryos: Historical perspective and current issues
    • Summers MC, Biggers JD. 2003. Chemically defined media and the culture of mammalian preimplantation embryos: Historical perspective and current issues. Hum Reprod Update 9:557-582.
    • (2003) Hum Reprod Update , vol.9 , pp. 557-582
    • Summers, M.C.1    Biggers, J.D.2
  • 63
    • 0036851172 scopus 로고    scopus 로고
    • Epigenetic risks related to assisted reproductive technologies: Short-and long-term consequences for the health of children conceived through assisted reproduction technology: More reason for caution?
    • Thompson JG, Kind KL, Roberts CT, Robertson SA, Robinson JS. 2002. Epigenetic risks related to assisted reproductive technologies: Short-and long-term consequences for the health of children conceived through assisted reproduction technology: More reason for caution? Hum Reprod 17:2783-2786.
    • (2002) Hum Reprod , vol.17 , pp. 2783-2786
    • Thompson, J.G.1    Kind, K.L.2    Roberts, C.T.3    Robertson, S.A.4    Robinson, J.S.5
  • 64
    • 0031662164 scopus 로고    scopus 로고
    • Transcription of IAP endogenous retroviruses is constrained by cytosine methylation
    • Walsh CP, Chaillet JR, Bestor TH. 1998. Transcription of IAP endogenous retroviruses is constrained by cytosine methylation. Nat Genet 20:116-117.
    • (1998) Nat Genet , vol.20 , pp. 116-117
    • Walsh, C.P.1    Chaillet, J.R.2    Bestor, T.H.3
  • 67
    • 0037499536 scopus 로고    scopus 로고
    • Timing of blastocyst expansion affects spatial messenger RNA expression patterns of genes in bovine blastocysts produced in vitro
    • Wrenzycki C, Herrmann D, Niemann H. 2003. Timing of blastocyst expansion affects spatial messenger RNA expression patterns of genes in bovine blastocysts produced in vitro. Biol Reprod 68:2073-2080.
    • (2003) Biol Reprod , vol.68 , pp. 2073-2080
    • Wrenzycki, C.1    Herrmann, D.2    Niemann, H.3
  • 68
    • 3543097592 scopus 로고    scopus 로고
    • DNA methylation in the preimplantation embryo: The differing stories of the mouse and sheep
    • Young LE, Beaujean N. 2004. DNA methylation in the preimplantation embryo: The differing stories of the mouse and sheep. Anim Reprod Sci 82-83:61-78.
    • (2004) Anim Reprod Sci , vol.82-83 , pp. 61-78
    • Young, L.E.1    Beaujean, N.2


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