Manipulating nature: Might there be a cardiovascular price to pay for the miracle of assisted conception?

Circulation

Volumn 125, Issue 15, 2012, Pages 1832-1834

  Celermajer, David S ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

arterial stiffness; arteries; Editorials; endothelium; pathophysiology; pulmonary circulation

Indexed keywords

AORTA WALL; BECKWITH WIEDEMANN SYNDROME; CARDIOVASCULAR RISK; DNA METHYLATION; EDITORIAL; ENDOTHELIAL DYSFUNCTION; EPIGENETICS; FETUS WEIGHT; HAPPY PUPPET SYNDROME; HIGH RISK PATIENT; HUMAN; INCIDENCE; INFERTILITY THERAPY; PHENOTYPE; PRIORITY JOURNAL; PROGENY;

FEMALE; HUMANS; MALE; PULMONARY CIRCULATION; REPRODUCTIVE TECHNIQUES, ASSISTED; VASCULAR DISEASES;

EID: 84859754256     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.112.100479     Document Type: Editorial

References (19)

1. Sutcliffe AG, Ludwig M. Outcome of assisted reproduction. Lancet. 2007;370:351-359.
2. Basatemur E, Sutcliffe A. Follow-up of children born after ART. Placenta. 2008;29:135-140.
3. Barker DJ. The origins of the developmental origins theory. J Intern Med. 2007;261:412-417.
4. Rimm AA, Katayama AC, Diaz M, Katayama KP. A meta-analysis of controlled studies comparing major malformation rates in IVF and ICSI infants with naturally conceived children. J Assist Reprod Genet. 2004; 21:437-443.
5. Scherrer U, Rimoldi SF, Rexhaj E, Stuber T, Duplain H, Garcin S, de Marchi SF, Nicod P, Germond M, Alleman Y, Sartori C. Systemic and pulmonary vascular dysfunction in children conceived by assisted reproductive technologies. Circulation. 2012;125:1890-1896.
6. Ceelen M, van Weissenbruch MM, Vermeiden JP, van Leeuwen FE, Delemarre-van de Waal HA. Cardiometabolic differences in children born after in vitro fertilization: follow-up study. J Clin Endocrinol Metab. 2008;93:1682-1688.
7. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK, Deanfield JE. Non-invasive detection of endothe-lial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992;340:1111-1115.
8. Celermajer DS, Cullen S, Deanfield JE. Impairment of endothelium- dependent pulmonary artery relaxation in children with congenital heart disease and abnormal pulmonary hemodynamics. Circulation. 1993;87: 440-446.
9. Napoli C, D'Armiento FP, Mancini FP, Postiglione A, Witztum JL, Palumbo G, Palinski W. Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia: intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions. J Clin Invest. 1997;100:2680-2690.
10. Skilton MR, Evans N, Griffiths KA, Harmer JA, Celermajer DS. Aortic wall thickness in newborns with intrauterine growth restriction. Lancet. 2005;365:1484-1486.
11. Gnoth C, Maxrath B, Skonieczny T, Friol K, Godehardt E, Tigges J. Final ART success rates: a 10 years survey. Hum Reprod. 2011;26:2239-2246.
12. Thompson JG, Kind KL, Roberts CT, Robertson SA, Robinson JS. Epigenetic risks related to assisted reproductive technologies: short-and long-term consequences for the health of children conceived through assisted reproduction technology: more reason for caution? Hum Reprod. 2002;17:2783-2786.
13. Leese HJ, Donnay I, Thompson JG. Human assisted conception: a cautionary tale: lessons from domestic animals. Hum Reprod. 1998;13: 184-202.
14. Niemitz EL, Feinberg AP. Epigenetics and assisted reproductive technology: a call for investigation. Am J Hum Genet. 2004;74:599-609.
15. Owen CM, Segars JH Jr. Imprinting disorders and assisted reproductive technology. Semin Reprod Med. 2009;27:417-428.
16. Gicquel C, Gaston V, Mandelbaum J, Siffroi JP, Flahault A, Le Bouc Y. In vitro fertilization may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCN1OT gene. Am J Hum Genet. 2003;72:1338-1341.
17. Rexhaj E, Giacobino A, Nicod P, Germond M, Sartori C, Sherrer U. Mice generated by assisted reproductive technologies, a model organism for the study of epigenetic mechanisms of vascular dysfunction in vivo. Circulation. 2010;122:A19117.
18. Rexhaj E, Bloch J, Jayet PY, Rimoldi SF, Dessen P, Mathieu C, Tolsa JF, Nicod P, Scherrer U, Sartori C. Fetal programming of pulmonary vascular dysfunction in mice: role of epigenetic mechanisms. Am J Physiol Heart Circ Physiol. 2011;301:H247-H252.
19. Khosla S, Dean W, Brown D, Reik W, Feil R. Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes. Biol Reprod. 2001;64:918-926.