The longer-term health outcomes for children born as a result of ivf treatment: Part i-general health outcomes

Human Reproduction Update

Volumn 19, Issue 3, 2013, Pages 232-243

  Hart, Roger ^a,b   Norman, Robert J ^c  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b Fertility Specialists of Western Australia   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Art; Icsi; Ivf; Long term outcome; Metabolic syndrome

Indexed keywords

ACADEMIC ACHIEVEMENT; ADDICTION; ANXIETY DISORDER; ARTICLE; ATTENTION DEFICIT DISORDER; AUTISM; BINGE DRINKING; CEREBRAL PALSY; CHILD; CHILD DEVELOPMENT; CHILD HEALTH; COGNITION; COGNITIVE DEVELOPMENT; DEPRESSION; DEVELOPMENTAL DISORDER; DRINKING; ENVIRONMENTAL FACTOR; FERTILIZATION IN VITRO; FOLLOW UP; HEREDITY; HUMAN; INTELLIGENCE QUOTIENT; LOW BIRTH WEIGHT; MENTAL DEVELOPMENT; MENTAL HEALTH; MOTOR DEVELOPMENT; OUTCOME ASSESSMENT; PREMATURITY; PRIORITY JOURNAL; PSYCHOSOCIAL DEVELOPMENT; SMOKING; SOCIAL BEHAVIOR; SOCIAL INTERACTION; SYSTEMATIC REVIEW; SYSTEMATIC REVIEW (TOPIC);

BODY FAT DISTRIBUTION; CARDIOVASCULAR DISEASES; FASTING; FEMALE; FERTILIZATION IN VITRO; HEALTH; HUMANS; HYPERGLYCEMIA; HYPERTENSION; INFANT; METABOLIC DISEASES; PREGNANCY; THYROID DISEASES;

EID: 84876814318     PISSN: 13554786     EISSN: 14602369     Source Type: Journal    
DOI: 10.1093/humupd/dms062     Document Type: Article

References (105)

1. Abitbol CL, Rodriguez MM. The long-term renal and cardiovascular consequences of prematurity. Nat Rev Nephrol 2012;8:265-274.
2. Allen VM, Wilson RD, Cheung A. Pregnancy outcomes after assisted reproductive technology. J Obstet Gynaecol Can 2006;28:220-250.
3. Barker DJ. Adult consequences of fetal growth restriction. Clin Obstet Gynecol 2006; 49:270-283.
4. Barker DJ, Osmond C, Golding J, Kuh D, Wadsworth ME. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ 1989;298:564-567.
5. Basatemur E, Shevlin M, Sutcliffe A. Growth of children conceived by IVF and ICSI up to 12years of age. Reprod Biomed Online 2010;20:144-149.
6. Basso O, Baird DD. Infertility and preterm delivery, birthweight, and Caesarean section: a study within the Danish National Birth Cohort. Hum Reprod 2003; 18:2478-2484.
7. Belva F, Henriet S, Liebaers I, Van Steirteghem A, Celestin-Westreich S, Bonduelle M. Medical outcome of 8-year-old singleton ICSI children (born > or = 32 weeks' gestation) and a spontaneously conceived comparison group. Hum Reprod 2007;22:506-515.
8. Belva F, Bonduelle M, Painter RC, Schiettecatte J, Devroey P, De Schepper J. Serum inhibin B concentrations in pubertal boys conceived by ICSI: first results. Hum Reprod 2010;25:2811-2814.
9. Belva F, Painter R, Bonduelle M, Roelants M, Devroey P, De Schepper J. Are ICSI adolescents at risk for increased adiposity? Hum Reprod 2012a;27:257-264.
10. Belva F, Roelants M, Painter R, Bonduelle M, Devroey P, De Schepper J. Pubertal development in ICSI children. Hum Reprod 2012b;27:1156-1161.
11. Beydoun HA, Sicignano N, Beydoun MA, Matson DO, Bocca S, Stadtmauer L, Oehninger S. A cross-sectional evaluation of the first cohort of young adults conceived by in vitro fertilization in the United States. Fertil Steril 2010; 94:2043-2049.
12. Beydoun HA, Sicignano N, Beydoun MA, Bocca S, Stadtmauer L, Oehninger S. Pubertal development of the first cohort of young adults conceived by in vitro fertilization in the United States. Fertil Steril 2011;95:528-533.
13. Bonduelle M, Wennerholm UB, Loft A, Tarlatzis BC, Peters C, Henriet S, Mau C, Victorin-Cederquist A, Van Steirteghem A, Balaska A et al. A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception. Hum Reprod 2005;20:413-419.
14. Bower C, Hansen M. Assisted reproductive technologies and birth outcomes: overview of recent systematic reviews. Reprod Fertil Dev 2005;17:329-333.
15. Bruinsma F, Venn A, Lancaster P, Speirs A, Healy D. Incidence of cancer in children born after in-vitro fertilization. Hum Reprod 2000;15:604-607.
16. Ceelen M, van Weissenbruch MM, Roos JC, Vermeiden JP, van Leeuwen FE, Delemarre-van de Waal HA. Body composition in children and adolescents born after in vitro fertilization or spontaneous conception. J Clin Endocrinol Metab 2007;92:3417-3423.
17. Ceelen M, van Weissenbruch MM, Vermeiden JP, van Leeuwen FE, Delemarre-van de Waal HA. Cardiometabolic differences in children born after in vitro fertilization: follow-up study. J Clin Endocrinol Metab 2008a;93:1682-1688.
18. Ceelen M, van Weissenbruch MM, Vermeiden JP, van Leeuwen FE, Delemarre-van de Waal HA. Growth and development of children born after in vitro fertilization. Fertil Steril 2008b;90:1662-1673.
19. Ceelen M, van Weissenbruch MM, Vermeiden JP, van Leeuwen FE, Delemarre-van de Waal HA. Pubertal development in children and adolescents born after IVF and spontaneous conception. Hum Reprod 2008c;23:2791-2798.
20. Ceelen M, van Weissenbruch MM, Prein J, Smit JJ, Vermeiden JP, Spreeuwenberg M, van Leeuwen FE, Delemarre-van de Waal HA. Growth during infancy and early childhood in relation to blood pressure and body fat measures at age 8-18 years of IVF children and spontaneously conceived controls born to subfertile parents. Hum Reprod 2009;24:2788-2795.
21. Cetinkaya F, Gelen SA, Kervancioglu E, Oral E. Prevalence of asthma and other allergic diseases in children born after in vitro fertilisation. Allergol Immunopathol (Madr) 2009;37:11-13.
22. Chang HJ, Lee JR, Jee BC, Suh CS, Kim SH. Impact of blastocyst transfer on offspring sex ratio and the monozygotic twinning rate: a systematic review and meta-analysis. Fertil Steril 2009;91:2381-2390.
23. Cram DS, Ma K, Bhasin S, Arias J, Pandjaitan M, Chu B, Audrins MS, Saunders D, Quinn F, de Kretser D et al. Y chromosome analysis of infertile men and their sons conceived through intracytoplasmic sperm injection: vertical transmission of deletions and rarity of de novo deletions. Fertil Steril 2000;74:909-915.
24. Das S, Blake D, Farquhar C, Seif MM. Assisted hatching on assisted conception (IVF and ICSI). Cochrane Database Syst Rev 2009;Issue 2:CD001894.
25. Davies MJ, Moore VM, Willson KJ, Van Essen P, Priest K, Scott H, Haan EA, Chan A. Reproductive technologies and the risk of birth defects. N Engl J Med 2012; 366:1803-1813.
26. De Schepper J, Belva F, Schiettecatte J, Anckaert E, Tournaye H, Bonduelle M. Testicular growth and tubular function in prepubertal boys conceived by intracytoplasmic sperm injection. Horm Res 2009;71:359-363.
27. Dommering CJ, van der Hout AH, Meijers-Heijboer H, Marees T, Moll AC. IVF and retinoblastoma revisited. Fertil Steril 2012;97:79-81.
28. Ericson A, Nygren KG, Olausson PO, Kallen B. Hospital care utilization of infants born after IVF. Hum Reprod 2002;17:929-932.
29. Eriksson JG, Osmond C, Kajantie E, Forsen TJ, Barker DJ. Patterns of growth among children who later develop type 2 diabetes or its risk factors. Diabetologia 2006; 49:2853-2858.
30. ESHRE. ESHRE ART fact sheet. In: ESoHRa (ed). Embryology 2011 http://www.eshre.eu/ESHRE/English/Guidelines-Legal/ART-fact-sheet/page.aspx/1061.
31. Farin CE, Farin PW, Piedrahita JA. Development of fetuses from in vitro-produced and cloned bovine embryos. J Anim Sci 2004;82(E-Suppl):E53-62.
32. Felix AS, Bruinsma F, Klemetti R, Gissler M, Lerner-Geva L, Taioli E. International pooled analysis of cancer incidence in children after assisted reproductive technologies: interim report. Future Oncol 2009;5:901-906.
33. Feng C, Wang LQ, Dong MY, Huang HF. Assisted reproductive technology may increase clinical mutation detection in male offspring. Fertil Steril 2008;90:92-96.
34. Fleming TP, Lucas ES, Watkins AJ, Eckert JJ. Adaptive responses of the embryo to maternal diet and consequences for post-implantation development. Reprod Fertil Dev 2011;24:35-44.
35. Fleming TP, Velazquez MA, Eckert JJ, Lucas ES, Watkins AJ. Nutrition of females during the peri-conceptional period and effects on foetal programming and health of offspring. Anim Reprod Sci 2012;130:193-197.
36. Halliday J. Outcomes of IVF conceptions: are they different? Best Pract Res Clin Obstet Gynaecol 2007;21:67-81.
37. Hansen M, Bower C, Milne E, de Klerk N, Kurinczuk JJ. Assisted reproductive technologies and the risk of birth defects-a systematic review. Hum Reprod 2005;20:328-338.
38. Hansen M, Colvin L, Petterson B, Kurinczuk JJ, de Klerk N, Bower C. Twins born following assisted reproductive technology: perinatal outcome and admission to hospital. Hum Reprod 2009;24:2321-2331.
39. Helmerhorst FM, Perquin DA, Donker D, Keirse MJ. Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ 2004;328:261.
40. Henningsen AK, Pinborg A, Lidegaard O, Vestergaard C, Forman JL, Andersen AN. Perinatal outcome of singleton siblings born after assisted reproductive technology and spontaneous conception: Danish national sibling-cohort study. Fertil Steril. 2010;95:959-963.
41. Hohmann FP, Macklon NS, Fauser BC. A randomized comparison of two ovarian stimulation protocols with gonadotropin-releasing hormone (GnRH) antagonist cotreatment for in vitro fertilization commencing recombinant follicle-stimulating hormone on cycle day 2 or 5 with the standard long GnRH agonist protocol. J Clin Endocrinol Metab 2003;88:166-173.
42. Hui LL, Wong MY, Lam TH, Leung GM, Schooling CM. Infant growth and onset of puberty: prospective observations from Hong Kong's 'Children of 1997' birth cohort. Ann Epidemiol 2012;22:43-50.
43. Ibanez L, Potau N, de Zegher F. Precocious pubarche, dyslipidemia, and low IGF binding protein-1 in girls: relation to reduced prenatal growth. Pediatr Res 1999; 46:320-322.
44. Ibanez L, Ferrer A, Marcos MV, Hierro FR, de Zegher F. Early puberty: rapid progression and reduced final height in girls with low birth weight. Pediatrics 2000;106:E72.
45. Jaakkola JJ, Ahmed P, Ieromnimon A, Goepfert P, Laiou E, Quansah R, Jaakkola MS. Preterm delivery and asthma: a systematic review and meta-analysis. J Allergy Clin Immunol 2006;118:823-830.
46. Jackson RA, Gibson KA, Wu YW, Croughan MS. Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet Gynecol 2004;103:551-563.
47. Kai CM, Main KM, Andersen AN, Loft A, Chellakooty M, Skakkebaek NE, Juul A. Serum insulin-like growth factor-I (IGF-I) and growth in children born after assisted reproduction. J Clin Endocrinol Metab 2006;91:4352-4360.
48. Kallen B, Finnstrom O, Nygren KG, Olausson PO. In vitro fertilization in Sweden: child morbidity including cancer risk. Fertil Steril 2005;84:605-610.
49. Kallen B, Finnstrom O, Lindam A, Nilsson E, Nygren KG, Olausson PO. Cancer risk in children and young adults conceived by in vitro fertilization. Pediatrics 2010; 126:270-276.
50. Kalra SK, Barnhart KT. In vitro fertilization and adverse childhood outcomes: what we know, where we are going, and how we will get there. A glimpse into what lies behind and beckons ahead. Fertil Steril 2011;95:1887-1889.
51. Kato K, Takehara Y, Segawa T, Kawachiya S, Okuno T, Kobayashi T, Bodri D, Kato O. Minimal ovarian stimulation combined with elective single embryo transfer policy: age-specific results of a large, single-centre, Japanese cohort. Reprod Biol Endocrinol 2012a;10:35.
52. Kato O, Kawasaki N, Bodri D, Kuroda T, Kawachiya S, Kato K, Takehara Y. Neonatal outcome and birth defects in 6623 singletons born following minimal ovarian stimulation and vitrified versus fresh single embryo transfer. Eur J Obstet Gynecol Reprod Biol 2012b;161:46-50.
53. Klip H, Burger CW, de Kraker J, van Leeuwen FE. Risk of cancer in the offspring of women who underwent ovarian stimulation for IVF. Hum Reprod 2001; 16:2451-2458.
54. Knoester M, Helmerhorst FM, van der Westerlaken LA, Walther FJ, Veen S. Matched follow-up study of 5 8-year-old ICSI singletons: child behaviour, parenting stress and child (health-related) quality of life. Hum Reprod 2007; 22:3098-3107.
55. Knoester M, Helmerhorst FM, Vandenbroucke JP, van der Westerlaken LA, Walther FJ, Veen S. Perinatal outcome, health, growth, and medical care utilization of 5- to 8-year-old intracytoplasmic sperm injection singletons. Fertil Steril 2008;89:1133-1146.
56. Koivurova S, Hartikainen AL, Sovio U, Gissler M, Hemminki E, Jarvelin MR. Growth, psychomotor development and morbidity up to 3 years of age in children born after IVF. Hum Reprod 2003;18:2328-2336.
57. Koivurova S, Hartikainen AL, Gissler M, Hemminki E, Jarvelin MR. Post-neonatal hospitalization and health care costs among IVF children: a 7-year follow-up study. Hum Reprod 2007;22:2136-2141.
58. Lerner-Geva L, Toren A, Chetrit A, Modan B, Mandel M, Rechavi G, Dor J. The risk for cancer among children of women who underwent in vitro fertilization. Cancer 2000;88:2845-2847.
59. Leunissen RW, Kerkhof GF, Stijnen T, Hokken-Koelega A. Timing and tempo of first-year rapid growth in relation to cardiovascular and metabolic risk profile in early adulthood. JAMA 2009;301:2234-2242.
60. Ludwig M. Development of children born after IVF and ICSI. Reprod Biomed Online 2004;9:10-12.
61. Ludwig AK, Sutcliffe AG, Diedrich K, Ludwig M. Post-neonatal health and development of children born after assisted reproduction: a systematic review of controlled studies. Eur J Obstet Gynecol Reprod Biol 2006;127:3-25.
62. Ludwig AK, Katalinic A, Entenmann A, Thyen U, Sutcliffe AG, Diedrich K, Ludwig M. Can we sense ART? The blinded examiner is not blind-a problem with follow-up studies on children born after assisted reproduction. Fertil Steril 2009a;92:950-952.
63. Ludwig AK, Katalinic A, Thyen U, Sutcliffe AG, Diedrich K, Ludwig M. Physical health at 5.5 years of age of term-born singletons after intracytoplasmic sperm injection: results of a prospective, controlled, single-blinded study. Fertil Steril 2009b; 91:115-124.
64. Macklon NS, van der Gaast MH, Hamilton A, Fauser BC, Giudice LC. The impact of ovarian stimulation with recombinant FSH in combination with GnRH antagonist on the endometrial transcriptome in the window of implantation. Reprod Sci 2008; 15:357-365.
65. Maheshwari A, Pandey S, Shetty A, Hamilton M, Bhattacharya S. Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of frozen thawed versus fresh embryos generated through in vitro fertilization treatment: a systematic review and meta-analysis. Fertil Steril 2012;98:368-377 e369.
66. Manipalviratn S, De Cherney A, Segars J. Imprinting disorders and assisted reproductive technology. Fertil Steril 2009;91:305-315.
67. Marees T, Dommering CJ, Imhof SM, Kors WA, Ringens PJ, van Leeuwen FE, Moll AC. Incidence of retinoblastoma in Dutch children conceived by IVF: an expanded study. Hum Reprod 2009;24:3220-3224.
68. Miles HL, Hofman PL, Peek J, Harris M, Wilson D, Robinson EM, Gluckman PD, Cutfield WS. In vitro fertilization improves childhood growth and metabolism. J Clin Endocrinol Metab 2007;92:3441-3445.
69. Milne E, Laurvick CL, Blair E, de Klerk N, Charles AK, Bower C. Fetal growth and the risk of childhood CNS tumors and lymphomas in Western Australia. Int J Cancer 2008;123:436-443.
70. Moll AC, Imhof SM, Cruysberg JR, Schouten-van Meeteren AY, Boers M, van Leeuwen FE. Incidence of retinoblastoma in children born after in-vitro fertilisation. Lancet 2003;361:309-310.
71. Nakajo Y, Fukunaga N, Fuchinoue K, Yagi A, Chiba S, Takeda M, Kyono K, Araki Y. Physical and mental development of children after in vitro fertilization and embryo transfer. Reprod Med Biol 2004;3:63-67.
72. Norman RJ. The power of one and its cost. Med J Aust 2011;195:564-565.
73. Oliver VF, Miles HL, Cutfield WS, Hofman PL, Ludgate JL, Morison IM. Defects in imprinting and genome-wide DNA methylation are not common in the in vitro fertilization population. Fertil Steril 2012;97:147-153 e147.
74. Painter RC, Roseboom TJ, van Montfrans GA, Bossuyt PM, Krediet RT, Osmond C, Barker DJ, Bleker OP. Microalbuminuria in adults after prenatal exposure to the Dutch famine. J Am Soc Nephrol 2005;16:189-194.
75. Pinborg A, Lidegaard O, la Cour Freiesleben N, Andersen AN. Consequences of vanishing twins in IVF/ICSI pregnancies. Hum Reprod 2005;20:2821-2829.
76. Pinborg A, Lidegaard O, Andersen AN. The vanishing twin: a major determinant of infant outcome in IVF singleton births. Br J Hosp Med (Lond) 2006;67:417-420.
77. Raatikainen K, Kuivasaari-Pirinen P, Hippelainen M, Heinonen S. Comparison of the pregnancy outcomes of subfertile women after infertility treatment and in naturally conceived pregnancies. Hum Reprod 2012;27:1162-1169.
78. Raimondi S, Pedotti P, Taioli E. Meta-analysis of cancer incidence in children born after assisted reproductive technologies. Br J Cancer 2005;93:1053-1056.
79. Rojas-Marcos PM, David R, Kohn B. Hormonal effects in infants conceived by assisted reproductive technology. Pediatrics 2005;116:190-194.
80. Roseboom TJ, Painter RC, van Abeelen AF, Veenendaal MV, de Rooij SR. Hungry in the womb: what are the consequences? Lessons from the Dutch famine. Maturitas 2011;70:141-145.
81. Sakka SD, Malamitsi-Puchner A, Loutradis D, Chrousos GP, Kanaka-Gantenbein C. Euthyroid hyperthyrotropinemia in children born after in vitro fertilization. J Clin Endocrinol Metab 2009;94:1338-1341.
82. Sakka SD, Loutradis D, Kanaka-Gantenbein C, Margeli A, Papastamataki M, Papassotiriou I, Chrousos GP. Absence of insulin resistance and low-grade inflammation despite early metabolic syndrome manifestations in children born after in vitro fertilization. Fertil Steril 2010;94:1693-1699.
83. Schachter M, Raziel A, Friedler S, Strassburger D, Bern O, Ron-El R. Monozygotic twinning after assisted reproductive techniques: a phenomenon independent of micromanipulation. Hum Reprod 2001;16:1264-1269.
84. Schieve LA, Rasmussen SA, Buck GM, Schendel DE, Reynolds MA, Wright VC. Are children born after assisted reproductive technology at increased risk for adverse health outcomes? Obstet Gynecol 2004;103:1154-1163.
85. Shih W, Rushford DD, Bourne H, Garrett C, McBain JC, Healy DL, Baker HW. Factors affecting low birthweight after assisted reproduction technology: difference between transfer of fresh and cryopreserved embryos suggests an adverse effect of oocyte collection. Hum Reprod 2008;23:1644-1653.
86. Sicignano N, Beydoun HA, Russell H, Jones H Jr, Oehninger S. A descriptive study of asthma in young adults conceived by IVF. Reprod Biomed Online 2010;21:812-818.
87. Sloboda DM, Hart R, Doherty DA, Pennell CE, Hickey M. Age at menarche: Influences of prenatal and postnatal growth. J Clin Endocrinol Metab 2007; 92:46-50.
88. Spector LG, Klebanoff MA, Feusner JH, Georgieff MK, Ross JA. Childhood cancer following neonatal oxygen supplementation. J Pediatr 2005;147:27-31.
89. Steel AJ, Sutcliffe A. Long-term health implications for children conceived by IVF/ ICSI. Hum Fertil (Camb) 2009;12:21-27.
90. Sullivan EA, Wang YA, Hayward I, Chambers GM, Illingworth P, McBain J, Norman RJ. Single embryo transfer reduces the risk of perinatal mortality, a population study. Hum Reprod. 2012;27(12):3609-3615.
91. Sutcliffe AG, Taylor B, Saunders K, Thornton S, Lieberman BA, Grudzinskas JG. Outcome in the second year of life after in-vitro fertilisation by intracytoplasmic sperm injection: a UK case-control study. Lancet 2001;357:2080-2084.
92. Tideman E, Marsal K, Ley D. Cognitive function in young adults following intrauterine growth restriction with abnormal fetal aortic blood flow. Ultrasound Obstet Gynecol 2007;29:614-618.
93. Tornqvist K, Finnstrom O, Kallen B, Lindam A, Nilsson E, Nygren KG, Olausson PO. Ocular malformations or poor visual acuity in children born after in vitro fertilization in Sweden. Am J Ophthalmol 2010;150:23-26.
94. Uzunlulu M, Yorulmaz E, Oguz A. Prevalence of subclinical hypothyroidism in patients with metabolic syndrome. Endocr J 2007;54:71-76.
95. van der Gaast MH, Classen-Linke I, Krusche CA, Beier-Hellwig K, Fauser BC, Beier HM, Macklon NS. Impact of ovarian stimulation on mid-luteal endometrial tissue and secretion markers of receptivity. Reprod Biomed Online 2008;17:553-563.
96. Vialard F, Boitrelle F, Molina-Gomes D, Selva J. Predisposition to aneuploidy in the oocyte. Cytogenet Genome Res 2011;133:127-135.
97. Wang YA, Sullivan EA, Healy DL, Black DA. Perinatal outcomes after assisted reproductive technology treatment in Australia and New Zealand: single versus double embryo transfer. Med J Aust 2009;190:234-237.
98. Wang YA, Macaldowie A, Hayward I, Chambers GM, Sullivan EA. Assisted Reproductive Technology in Australia and New Zealand 2009. Canberra: AIHW, 2011.
99. Wennerholm UB, Albertsson-Wikland K, Bergh C, Hamberger L, Niklasson A, Nilsson L, Thiringer K, Wennergren M, Wikland M, Borres MP. Postnatal growth and health in children born after cryopreservation as embryos. Lancet 1998;351:1085-1090.
100. Wennerholm UB, Soderstrom-Anttila V, Bergh C, Aittomaki K, Hazekamp J, Nygren KG, Selbing A, Loft A. Children born after cryopreservation of embryos or oocytes: a systematic review of outcome data. Hum Reprod 2009; 24:2158-2172.
101. Williams C, Sutcliffe A. Infant outcomes of assisted reproduction. Early Hum Dev 2009;85:673-677.
102. Wilson CL, Fisher JR, Hammarberg K, Amor DJ, Halliday JL. Looking downstream: a review of the literature on physical and psychosocial health outcomes in adolescents and young adults who were conceived by ART. Hum Reprod 2011; 26:1209-1219.
103. Winston RM, Hardy K. Are we ignoring potential dangers of in vitro fertilization and related treatments? Nat Cell Biol 2002;4(Suppl):s14-18.
104. Young LE, Fernandes K, McEvoy TG, Butterwith SC, Gutierrez CG, Carolan C, Broadbent PJ, Robinson JJ, Wilmut I, Sinclair KD. Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture. Nat Genet 2001; 27:153-154.
105. Zhu JL, Obel C, Hammer Bech B, Olsen J, Basso O. Infertility, infertility treatment, and fetal growth restriction. Obstet Gynecol 2007;110:1326-1334