Stable, uncleaved HIV-1 envelope glycoprotein gp140 forms a tightly folded trimer with a native-like structure

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 52, 2014, Pages 18542-18547

  Kovacs, James M ^a   Noeldeke, Erik ^c   Ha, Heather Jiwon ^a   Peng, Hanqin ^a   Rits Volloch, Sophia ^a   Harrisona, Stephen C ^a,b   Chen, Bing ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; FURIN; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 140; GLYCOPROTEIN GP 41; SOLUBLE CD4 ANTIGEN; GP140 ENVELOPE PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; VIRUS ENVELOPE PROTEIN;

ANTIGENICITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; GEL FILTRATION CHROMATOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN STRUCTURE; SURFACE PLASMON RESONANCE; VIRUS ENVELOPE; VIRUS SPIKE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL LINE; CRICETULUS; GENETICS; HAMSTER; HUMAN; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV-1; HUMANS; MODELS, MOLECULAR; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY;

EID: 84923154103     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1422269112     Document Type: Article

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