Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 7, 2015, Pages E607-E615

  Lu, Yao ^a   Xue, Qiong ^a   Eisele, Markus R ^a,b   Sulistijo, Endah S ^a   Brower, Kara ^c   Han, Lin ^a   Amir, El Ad David ^d   Pe'er, Dana ^d   Miller Jensen, Kathryn ^a,e,f   Fan, Rong ^a,f,g  

^a Yale University   (United States)

^b UNIVERSITY OF STUTTGART   (Germany)

^c IsoPlexis ^*  (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e YALE UNIVERSITY   (United States)

^f YALE CANCER CENTER   (United States)

^g YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cellular heterogeneity; Cytokine; Immune effector function; Single cell analysis; Toll like receptor activation

Indexed keywords

CARBON TETRACHLORIDE; DIMETICONE; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; LIGAND; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE MIGRATION INHIBITION FACTOR; TOLL LIKE RECEPTOR 4; TLR4 PROTEIN, HUMAN;

ARTICLE; BASAL CELL; CELL ACTIVATION; CELL COUNT; CELL CYCLE; CELL FUNCTION; CELL POPULATION; CELL SUBPOPULATION; CYTOKINE PRODUCTION; EFFECTOR CELL; FLOW CYTOMETRY; GRAM NEGATIVE BACTERIUM; HUMAN; HUMAN CELL; INNATE IMMUNITY; MACROPHAGE; MACROPHAGE MIGRATION; MONOCYTE; PATHOGENICITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SECRETION; SINGLE CELL ANALYSIS; TRANSPORT VESICLE; DRUG EFFECTS; METABOLISM; U937 CELL LINE; VALIDATION STUDY; VIRULENCE;

HUMANS; LIGANDS; LIPOPOLYSACCHARIDES; MACROPHAGES; SINGLE-CELL ANALYSIS; TOLL-LIKE RECEPTOR 4; U937 CELLS; VIRULENCE;

EID: 84923132388     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1416756112     Document Type: Article

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